Skip to content

Study · Animal study (in vivo) · rat · 2020

9 results

Erythropoietin Mimetic Peptide (pHBSP) Corrects Endothelial Dysfunction in a Rat Model of Preeclampsia.

Korokin M, Gureev V, Gudyrev O, Golubev I, Korokina L, Peresypkina A, Pokrovskaia T, Lazareva G, Soldatov V, Zatolokina M, Pobeda A, Avdeeva E and 5 more

Show all authors

Beskhmelnitsyna E, Denisyuk T, Avdeeva N, Bushueva O, Pokrovskii M

International journal of molecular sciences15 Sept 2020Cited by 3 (Europe PMC)

PMID32942669 (opens in a new tab)PMCIDPMC7554893 (opens in a new tab)DOI10.3390/ijms21186759 (opens in a new tab)PepBankPUB-32942669
Download PDFPubMedAsk about this study
Jump to 9 results

Summary

Preeclampsia is a severe disease of late pregnancy. Etiological factors and a pathogenetic pattern of events still require significant clarification, but it is now recognized that a large role is played by placentation disorders and emerging endothelial dysfunction. The administration of short-chain peptides mimicking the spatial structure of the B erythropoietin chain may become one of the directions of searching for new drugs for preeclampsia prevention and therapy. Simulation of ADMA-like preeclampsia in Wistar rats was performed by the administration of a non-selective NOS blocker L-NAME from the 14th to 20th day of pregnancy. The administration of the pHBSP at the doses of 10 µg/kg and 250 µg/kg corrected the established morphofunctional disorders. The greatest effect was observed at a dose of 250 µg/kg. There was a decrease in systolic and diastolic blood pressure by 31.2 and 32.8%, respectively (p < 0.0001), a decrease in the coefficient of endothelial dysfunction by 48.6% (p = 0.0006), placental microcirculation increased by 82.8% (p < 0.0001), the NOx concentration was increased by 42,6% (p = 0.0003), the greater omentum edema decreased by 11.7% (p = 0.0005) and proteinuria decreased by 76.1% (p < 0.0002). In addition, there was an improvement in the morphological pattern of the fetoplacental complex and the ratio of BAX to Bcl-2 expression which characterizes the apoptotic orientation of the cells.
CC BYText from Europe PMC. Highlighted sentences are the source of results.

Results from this study9

9 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In pregnant rats with L-NAME-induced preeclampsia, pHBSP decreased systolic blood pressure by 31.2%.

    In plain wordsIn rats with a preeclampsia-like condition, the peptide lowered systolic blood pressure.

    Peptide
    Cibinetide (ARA-290)
    Outcome
    DecreaseSystolic blood pressure
    Study

    ratn: not reported in source

    L-NAME-induced preeclampsia-like model in pregnant Wistar rats
    Outcome group
    Blood pressure · Cardiovascular
    Studied dose
    10 and 250 µg/kgAs given in this study (rat).

    Measurements

    Decrease in systolic blood pressure
    31.2%
    pHBSP

    Source sentences

    Summary
    There was a decrease in systolic and diastolic blood pressure by 31.2 and 32.8%, respectively (p < 0.0001)
    2 context sentences
    Summary · context
    Simulation of ADMA-like preeclampsia in Wistar rats was performed by the administration of a non-selective NOS blocker L-NAME from the 14th to 20th day of pregnancy.
    Summary · context
    The greatest effect was observed at a dose of 250 µg/kg.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In pregnant rats with L-NAME-induced preeclampsia, pHBSP decreased diastolic blood pressure by 32.8%.

    In plain wordsIn rats with a preeclampsia-like condition, the peptide lowered diastolic blood pressure.

    Peptide
    Cibinetide (ARA-290)
    Outcome
    DecreaseDiastolic blood pressure
    Study

    ratn: not reported in source

    L-NAME-induced preeclampsia-like model in pregnant Wistar rats
    Outcome group
    Blood pressure · Cardiovascular
    Studied dose
    10 and 250 µg/kgAs given in this study (rat).

    Measurements

    Decrease in diastolic blood pressure
    32.8%
    pHBSP

    Source sentences

    Summary
    There was a decrease in systolic and diastolic blood pressure by 31.2 and 32.8%, respectively (p < 0.0001)
    2 context sentences
    Summary · context
    Simulation of ADMA-like preeclampsia in Wistar rats was performed by the administration of a non-selective NOS blocker L-NAME from the 14th to 20th day of pregnancy.
    Summary · context
    The greatest effect was observed at a dose of 250 µg/kg.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In pregnant rats with L-NAME-induced preeclampsia, pHBSP decreased the coefficient of endothelial dysfunction by 48.6%.

    In plain wordsIn rats with a preeclampsia-like condition, the peptide reduced a measure of blood vessel lining dysfunction.

    Peptide
    Cibinetide (ARA-290)
    Outcome
    DecreaseCoefficient of endothelial dysfunction
    Study

    ratn: not reported in source

    L-NAME-induced preeclampsia-like model in pregnant Wistar rats
    Outcome group
    Vascular function · Cardiovascular
    Studied dose
    10 and 250 µg/kgAs given in this study (rat).

    Measurements

    Decrease in coefficient of endothelial dysfunction
    48.6%
    pHBSP

    Source sentences

    Summary
    a decrease in the coefficient of endothelial dysfunction by 48.6% (p = 0.0006)
    1 context sentence
    Summary · context
    Simulation of ADMA-like preeclampsia in Wistar rats was performed by the administration of a non-selective NOS blocker L-NAME from the 14th to 20th day of pregnancy.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In pregnant rats with L-NAME-induced preeclampsia, pHBSP increased placental microcirculation by 82.8%.

    In plain wordsIn rats with a preeclampsia-like condition, the peptide improved blood flow in the placenta.

    Peptide
    Cibinetide (ARA-290)
    Outcome
    IncreasePlacental microcirculation
    Study

    ratn: not reported in source

    L-NAME-induced preeclampsia-like model in pregnant Wistar rats
    Outcome group
    Vascular function · Reproductive and sexual health
    Studied dose
    10 and 250 µg/kgAs given in this study (rat).

    Measurements

    Increase in placental microcirculation
    82.8%
    pHBSP

    Source sentences

    Summary
    placental microcirculation increased by 82.8% (p < 0.0001)
    1 context sentence
    Summary · context
    Simulation of ADMA-like preeclampsia in Wistar rats was performed by the administration of a non-selective NOS blocker L-NAME from the 14th to 20th day of pregnancy.
  5. 05AnimalAnimal study (in vivo)Efficacy outcome

    In pregnant rats with L-NAME-induced preeclampsia, pHBSP increased the NOx concentration by 42.6%.

    In plain wordsIn rats with a preeclampsia-like condition, the peptide raised levels of NOx, a nitric oxide marker.

    Peptide
    Cibinetide (ARA-290)
    Outcome
    IncreaseNOx concentration
    Study

    ratn: not reported in source

    L-NAME-induced preeclampsia-like model in pregnant Wistar rats
    Outcome group
    Vascular function · Cardiovascular
    Studied dose
    10 and 250 µg/kgAs given in this study (rat).

    Measurements

    Increase in NOx concentration
    42.6%
    pHBSP

    Source sentences

    Summary
    the NOx concentration was increased by 42,6% (p = 0.0003)
    1 context sentence
    Summary · context
    Simulation of ADMA-like preeclampsia in Wistar rats was performed by the administration of a non-selective NOS blocker L-NAME from the 14th to 20th day of pregnancy.
  6. 06AnimalAnimal study (in vivo)Efficacy outcome

    In pregnant rats with L-NAME-induced preeclampsia, pHBSP decreased greater omentum edema by 11.7%.

    In plain wordsIn rats with a preeclampsia-like condition, the peptide reduced swelling in the omentum tissue.

    Peptide
    Cibinetide (ARA-290)
    Outcome
    DecreaseGreater omentum edema
    Study

    ratn: not reported in source

    L-NAME-induced preeclampsia-like model in pregnant Wistar rats
    Outcome group
    Vascular function · Cardiovascular
    Studied dose
    10 and 250 µg/kgAs given in this study (rat).

    Measurements

    Decrease in greater omentum edema
    11.7%
    pHBSP

    Source sentences

    Summary
    the greater omentum edema decreased by 11.7% (p = 0.0005)
    1 context sentence
    Summary · context
    Simulation of ADMA-like preeclampsia in Wistar rats was performed by the administration of a non-selective NOS blocker L-NAME from the 14th to 20th day of pregnancy.
  7. 07AnimalAnimal study (in vivo)Efficacy outcome

    In pregnant rats with L-NAME-induced preeclampsia, pHBSP decreased proteinuria by 76.1%.

    In plain wordsIn rats with a preeclampsia-like condition, the peptide reduced protein loss in the urine.

    Peptide
    Cibinetide (ARA-290)
    Outcome
    DecreaseProteinuria
    Study

    ratn: not reported in source

    L-NAME-induced preeclampsia-like model in pregnant Wistar rats
    Outcome group
    Kidney function · Kidney and urinary
    Studied dose
    10 and 250 µg/kgAs given in this study (rat).

    Measurements

    Decrease in proteinuria
    76.1%
    pHBSP

    Source sentences

    Summary
    proteinuria decreased by 76.1% (p < 0.0002).
    1 context sentence
    Summary · context
    Simulation of ADMA-like preeclampsia in Wistar rats was performed by the administration of a non-selective NOS blocker L-NAME from the 14th to 20th day of pregnancy.
  8. 08AnimalAnimal study (in vivo)Efficacy outcome

    In pregnant rats with L-NAME-induced preeclampsia, pHBSP improved the morphological pattern of the fetoplacental complex.

    In plain wordsIn rats with a preeclampsia-like condition, the peptide improved the look of the placenta and fetus tissue under the microscope.

    Peptide
    Cibinetide (ARA-290)
    Outcome
    Direction not reportedMorphological pattern of the fetoplacental complex
    Study

    ratn: not reported in source

    L-NAME-induced preeclampsia-like model in pregnant Wistar rats
    Outcome group
    Vascular function · Reproductive and sexual health
    Studied dose
    10 and 250 µg/kgAs given in this study (rat).

    Source sentences

    Summary
    In addition, there was an improvement in the morphological pattern of the fetoplacental complex
    1 context sentence
    Summary · context
    Simulation of ADMA-like preeclampsia in Wistar rats was performed by the administration of a non-selective NOS blocker L-NAME from the 14th to 20th day of pregnancy.
  9. 09AnimalAnimal study (in vivo)Mechanism

    In pregnant rats with L-NAME-induced preeclampsia, pHBSP improved the ratio of BAX to Bcl-2 expression, which characterizes the apoptotic orientation of the cells.

    In plain wordsIn rats with a preeclampsia-like condition, the peptide improved the balance of two cell-death regulating proteins.

    Peptide
    Cibinetide (ARA-290)
    Outcome
    Direction not reportedBAX to Bcl-2 expression ratio
    Study

    ratn: not reported in source

    L-NAME-induced preeclampsia-like model in pregnant Wistar rats
    Outcome group
    Receptor activity and mechanism · Reproductive and sexual health
    Studied dose
    10 and 250 µg/kgAs given in this study (rat).

    Source sentences

    Summary
    the ratio of BAX to Bcl-2 expression which characterizes the apoptotic orientation of the cells.
    1 context sentence
    Summary · context
    Simulation of ADMA-like preeclampsia in Wistar rats was performed by the administration of a non-selective NOS blocker L-NAME from the 14th to 20th day of pregnancy.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    9 Oct 2026, 19:08 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:13 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

PepBank is a research reference. Talk to a doctor before you use any peptide.