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Study · Animal study (in vivo) · mouse · 2020

5 results

Thymosin alpha-1 blocks the accumulation of myeloid suppressor cells in NSCLC by inhibiting VEGF production.

Yang Z, Guo J, Cui K, Du Y, Zhao H, Zhu L, Weng L, Tang W, Guo J, Zhang T, Shi X, Zong H, Jin S, Ma W

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie14 Sept 2020Cited by 12 (Europe PMC)

PMID32942159 (opens in a new tab)DOI10.1016/j.biopha.2020.110740 (opens in a new tab)PepBankPUB-32942159
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: CC BY-NC-ND. Results still quote short attributed sentences.

Results from this study5

5 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In a mouse subcutaneous xenograft model, thymosin alpha‑1 inhibited migration of MDSCs to the tumor microenvironment.

    In plain wordsIn mice with tumors, thymosin alpha‑1 reduced the movement of suppressor immune cells into the tumor.

    Peptide
    Thymosin alpha-1
    Outcome
    DecreaseMDSC migration to the tumor microenvironment
    Study

    mousen: not reported in source

    subcutaneous xenograft tumor model
    Outcome group
    Immune response · Cancer
    Studied dose
    Dose not stated

    Source sentences

    Summary
    inhibited the migration of MDSCs to the tumor microenvironment
    1 context sentence
    Summary · context
    A mouse subcutaneous xenograft tumor model was constructed, and the effect of TA on M-MDSC migration was evaluated.
  2. 02AnimalAnimal study (in vivo)Mechanism

    In a mouse subcutaneous xenograft model, thymosin alpha‑1 suppressed tumor production of VEGF.

    In plain wordsIn mice with tumors, thymosin alpha‑1 lowered the amount of VEGF that tumor cells made.

    Peptide
    Thymosin alpha-1
    Outcome
    DecreaseVEGF production in tumor cells
    Study

    mousen: not reported in source

    subcutaneous xenograft tumor model
    Outcome group
    Immune response · Cancer
    Studied dose
    Dose not stated

    Source sentences

    Summary
    suppressing the production of vascular endothelial growth factor (VEGF)
    1 context sentence
    Summary · context
    A mouse subcutaneous xenograft tumor model was constructed, and the effect of TA on M-MDSC migration was evaluated.
  3. 03AnimalAnimal study (in vivo)Mechanism

    In a mouse subcutaneous xenograft model, thymosin alpha‑1 downregulated HIF-1α in tumor cells.

    In plain wordsIn mice with tumors, thymosin alpha‑1 lowered HIF-1α in tumor cells.

    Peptide
    Thymosin alpha-1
    Outcome
    DecreaseHIF-1α expression in tumor cells
    Study

    mousen: not reported in source

    subcutaneous xenograft tumor model
    Outcome group
    Immune response · Cancer
    Studied dose
    Dose not stated

    Source sentences

    Summary
    downregulation of hypoxia-inducible factor (HIF)-1α in tumor cells.
    1 context sentence
    Summary · context
    A mouse subcutaneous xenograft tumor model was constructed, and the effect of TA on M-MDSC migration was evaluated.
  4. 04LabEx vivo tissueMechanism

    In M-MDSCs from patients with NSCLC, thymosin alpha‑1 promoted apoptosis.

    In plain wordsIn lab tests on immune cells from lung cancer blood samples, thymosin alpha‑1 made suppressor cells die more.

    Peptide
    Thymosin alpha-1
    Outcome
    IncreaseM-MDSC apoptosis
    Study

    humann: not reported in source

    peripheral blood M-MDSCs from patients with NSCLC
    Outcome group
    Immune response · Cancer
    Studied dose
    Dose not stated

    Source sentences

    Summary
    promoted the apoptosis of M-MDSCs by reducing the Bcl-2/BAX ratio
    1 context sentence
    Summary · context
    The effects of TA on peripheral blood monocytic MDSCs (M-MDSCs) in patients with NSCLC and on the apoptosis and migration of M-MDSCs were studied.
  5. 05LabEx vivo tissueMechanism

    In M-MDSCs from patients with NSCLC, thymosin alpha‑1 reduced the Bcl-2/BAX ratio.

    In plain wordsIn lab tests on immune cells from lung cancer blood samples, thymosin alpha‑1 lowered the Bcl-2/BAX ratio, a marker linked to cell death.

    Peptide
    Thymosin alpha-1
    Outcome
    DecreaseBcl-2/BAX ratio in M-MDSCs
    Study

    humann: not reported in source

    peripheral blood M-MDSCs from patients with NSCLC
    Outcome group
    Immune response · Cancer
    Studied dose
    Dose not stated

    Source sentences

    Summary
    reducing the Bcl-2/BAX ratio
    1 context sentence
    Summary · context
    The effects of TA on peripheral blood monocytic MDSCs (M-MDSCs) in patients with NSCLC and on the apoptosis and migration of M-MDSCs were studied.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    10 Oct 2026, 08:55 UTC

    Study results updated

  2. Version 2

    9 Oct 2026, 03:03 UTC

    Study data updated · source update from Europe PMC

  3. Version 1

    9 Oct 2026, 03:02 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

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