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Study · Randomized controlled trial · n = 56 · 2020

5 results

Oxytocin enhances the recovery of eye-contact induced autonomic arousal: A treatment mechanism study with placebo-controlled design.

Daniels N, Prinsen J, Soriano JR, Alaerts K

European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology28 Aug 2020Cited by 9 (Europe PMC)

PMID32868176 (opens in a new tab)DOI10.1016/j.euroneuro.2020.08.004 (opens in a new tab)PepBankPUB-32868176
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

5 results from studies that gave the peptide. 5 results from people.

  1. 01HumanRandomized controlled trialEfficacy outcome

    In healthy men, oxytocin significantly reduced self-reported feelings of tension compared with placebo in an exploratory analysis.

    In plain wordsIn healthy men, nasal oxytocin lowered self-reported tension compared with placebo in an exploratory analysis.

    Peptide
    Oxytocin
    Outcome
    DecreaseSelf-reported feelings of tension
    Study

    n = 56

    Comparator
    Placebo
    Analysis
    Exploratory
    Outcome group
    Anxiety and mood · Mental health and mood
    Studied dose
    24 IU · intranasal · single doseAs given in this study (human).

    Source sentences

    Summary
    Exploratory, it was shown that OT also significantly reduced self-reported feelings of tension and (at trend-level) worrying about how one presents oneself.
    1 context sentence
    Summary · context
    Here, a randomized double-blind, placebo-controlled study (with parallel design) was conducted with 56 healthy adult men to investigate whether a single-dose of OT (24 IU) modulates sympathetic autonomic arousal upon live dyadic gaze interactions.
  2. 02HumanRandomized controlled trialEfficacy outcome

    In healthy men, oxytocin reduced worrying about how one presents oneself only at trend level, not significantly, compared with placebo in an exploratory analysis.

    In plain wordsIn healthy men, nasal oxytocin showed only a weak, non-significant trend towards less worry about self-presentation compared with placebo.

    Peptide
    Oxytocin
    Outcome
    No significant changeSelf-reported worrying about self-presentation
    Study

    n = 56

    Comparator
    Placebo
    Analysis
    Exploratory
    Outcome group
    Anxiety and mood · Mental health and mood
    Studied dose
    24 IU · intranasal · single doseAs given in this study (human).

    Source sentences

    Summary
    and (at trend-level) worrying about how one presents oneself.
    1 context sentence
    Summary · context
    Here, a randomized double-blind, placebo-controlled study (with parallel design) was conducted with 56 healthy adult men to investigate whether a single-dose of OT (24 IU) modulates sympathetic autonomic arousal upon live dyadic gaze interactions.
  3. 03HumanRandomized controlled trialEfficacy outcome

    In healthy men, oxytocin did not change the amplitude of the skin conductance response to direct eye gaze compared with placebo.

    In plain wordsIn healthy men, nasal oxytocin did not change the size of the body's stress-arousal response to eye contact compared with placebo.

    Peptide
    Oxytocin
    Outcome
    No significant changeAmplitude of skin conductance response to direct eye gaze
    Study

    n = 56

    Comparator
    Placebo
    Outcome group
    Autonomic function · Nervous system and cognition
    Studied dose
    24 IU · intranasal · single doseAs given in this study (human).

    Source sentences

    Summary
    but OT did not specifically enhance or dampen the overall magnitude (amplitude) of the skin conductance response.
    1 context sentence
    Summary · context
    Here, a randomized double-blind, placebo-controlled study (with parallel design) was conducted with 56 healthy adult men to investigate whether a single-dose of OT (24 IU) modulates sympathetic autonomic arousal upon live dyadic gaze interactions.
  4. 04HumanRandomized controlled trialEfficacy outcome

    In healthy men, oxytocin reduced the time for skin conductance responses to recover to baseline after eye contact compared with placebo.

    In plain wordsIn healthy men, nasal oxytocin shortened the time for arousal from eye contact to settle compared with placebo.

    Peptide
    Oxytocin
    Outcome
    DecreaseRecovery time of skin conductance response
    Study

    n = 56

    Comparator
    Placebo
    Outcome group
    Autonomic function · Nervous system and cognition
    Studied dose
    24 IU · intranasal · single doseAs given in this study (human).

    Source sentences

    Summary
    Administration of OT did facilitate the recovery of skin conductance responses back to baseline (reduced recovery time), indicating a role of OT in restoring homeostatic balance.
    1 context sentence
    Summary · context
    Here, a randomized double-blind, placebo-controlled study (with parallel design) was conducted with 56 healthy adult men to investigate whether a single-dose of OT (24 IU) modulates sympathetic autonomic arousal upon live dyadic gaze interactions.
  5. 05HumanRandomized controlled trialEfficacy outcome

    In healthy men with low self-reported social responsiveness, the effect of oxytocin on autonomic recovery was most prominent.

    In plain wordsIn healthy men, the faster settling of arousal after nasal oxytocin was strongest in those who rated themselves low in social responsiveness.

    Peptide
    Oxytocin
    Outcome
    DecreaseAutonomic recovery in participants with low social responsiveness
    Study

    n = 56

    Comparator
    Placebo
    Outcome group
    Autonomic function · Nervous system and cognition
    Studied dose
    24 IU · intranasal · single doseAs given in this study (human).

    Source sentences

    Summary
    Notably, the treatment-effect on autonomic recovery was most prominent in participants with low self-reported social responsiveness, indicating that person-dependent factors play an important role in determining OT treatment-responses.
    1 context sentence
    Summary · context
    Here, a randomized double-blind, placebo-controlled study (with parallel design) was conducted with 56 healthy adult men to investigate whether a single-dose of OT (24 IU) modulates sympathetic autonomic arousal upon live dyadic gaze interactions.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 01:30 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:49 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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