The anorexigenic effect of vasoactive intestinal polypeptide in Japanese quail is associated with molecular changes in the arcuate and dorsomedial hypothalamic nuclei.

Bohler M, Gilbert ER, Cline MA

Domestic animal endocrinology21 May 2020Cited by 2 (Europe PMC)

PMID32858465DOI10.1016/j.domaniend.2020.106499PepBankPUB-32858465

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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study10

10 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Efficacy outcome
In 7-day-old Japanese quail chicks, ICV VIP reduced food intake for up to 180 min after injection.
In plain wordsIn young quail, VIP injected into the brain reduced food intake for up to 180 minutes.
Peptide
Vasoactive intestinal peptide (VIP, aviptadil)
Outcome
DecreaseFood intake up to 180 min
Study
Japanese quailn: not reported in source
7-day-old chicks
Outcome group
Appetite and food intake · Metabolic and weight
Studied dose
Dose not stated · intracerebroventricularAs given in this study (Japanese quail).
Source sentences
Summary
chicks that received intracerebroventricular (ICV) injection of VIP had reduced food intake for up to 180 min after injection
1 context sentence(design, population, supporting numbers)
Summary · context
The aim of the present study was thus to investigate hypothalamic mechanisms mediating VIP-induced satiety in 7-d old Japanese quail.
Report a problemFND-3285846501
02AnimalAnimal study (in vivo)Efficacy outcome
In 7-day-old Japanese quail chicks, ICV VIP reduced water intake for 90 min.
In plain wordsIn young quail, VIP injected into the brain reduced water intake for 90 minutes.
Peptide
Vasoactive intestinal peptide (VIP, aviptadil)
Outcome
DecreaseWater intake up to 90 min
Study
Japanese quailn: not reported in source
7-day-old chicks
Outcome group
Appetite and food intake · Metabolic and weight
Studied dose
Dose not stated · intracerebroventricularAs given in this study (Japanese quail).
Source sentences
Summary
chicks that received intracerebroventricular (ICV) injection of VIP had reduced food intake for up to 180 min after injection and reduced water intake for 90 min
1 context sentence(design, population, supporting numbers)
Summary · context
The aim of the present study was thus to investigate hypothalamic mechanisms mediating VIP-induced satiety in 7-d old Japanese quail.
Report a problemFND-3285846502
03AnimalAnimal study (in vivo)Efficacy outcome
In food-restricted 7-day-old Japanese quail chicks, ICV VIP did not reduce water intake.
In plain wordsIn young quail that were food restricted, VIP injected into the brain did not reduce water intake.
Peptide
Vasoactive intestinal peptide (VIP, aviptadil)
Outcome
No significant changeWater intake in food-restricted chicks
Study
Japanese quailn: not reported in source
7-day-old chicks
Outcome group
Appetite and food intake · Metabolic and weight
Studied dose
Dose not stated · intracerebroventricularAs given in this study (Japanese quail).
Source sentences
Summary
In experiment 2, VIP-treated chicks that were food restricted did not reduce water intake.
1 context sentence(design, population, supporting numbers)
Summary · context
The aim of the present study was thus to investigate hypothalamic mechanisms mediating VIP-induced satiety in 7-d old Japanese quail.
Report a problemFND-3285846503
04AnimalAnimal study (in vivo)Mechanism
In Japanese quail, VIP injection increased c-Fos immunoreactivity in the arcuate nucleus of the hypothalamus.
In plain wordsIn quail, VIP injection raised a marker of nerve cell activity in a brain area that controls appetite.
Peptide
Vasoactive intestinal peptide (VIP, aviptadil)
Outcome
Increasec-Fos immunoreactivity in arcuate nucleus
Study
Japanese quailn: not reported in source
7-day-old chicks
Outcome group
Appetite and food intake · Metabolic and weight
Studied dose
Dose not stated · intracerebroventricularAs given in this study (Japanese quail).
Source sentences
Summary
In experiment 3, there was increased c-Fos immunoreactivity in the arcuate (ARC) and dorsomedial (DMN) nuclei of the hypothalamus in VIP-injected quail.
1 context sentence(design, population, supporting numbers)
Summary · context
The aim of the present study was thus to investigate hypothalamic mechanisms mediating VIP-induced satiety in 7-d old Japanese quail.
Report a problemFND-3285846504
05AnimalAnimal study (in vivo)Mechanism
In Japanese quail, VIP injection increased c-Fos immunoreactivity in the dorsomedial nucleus of the hypothalamus.
In plain wordsIn quail, VIP injection raised a marker of nerve cell activity in a second brain area that controls appetite.
Peptide
Vasoactive intestinal peptide (VIP, aviptadil)
Outcome
Increasec-Fos immunoreactivity in dorsomedial nucleus
Study
Japanese quailn: not reported in source
7-day-old chicks
Outcome group
Appetite and food intake · Metabolic and weight
Studied dose
Dose not stated · intracerebroventricularAs given in this study (Japanese quail).
Source sentences
Summary
In experiment 3, there was increased c-Fos immunoreactivity in the arcuate (ARC) and dorsomedial (DMN) nuclei of the hypothalamus in VIP-injected quail.
1 context sentence(design, population, supporting numbers)
Summary · context
The aim of the present study was thus to investigate hypothalamic mechanisms mediating VIP-induced satiety in 7-d old Japanese quail.
Report a problemFND-3285846505
06AnimalAnimal study (in vivo)Mechanism
In Japanese quail, ICV VIP decreased neuropeptide Y mRNA in the arcuate nucleus.
In plain wordsIn quail, VIP injected into the brain lowered neuropeptide Y messenger RNA in a brain area that controls appetite.
Peptide
Vasoactive intestinal peptide (VIP, aviptadil)
Outcome
DecreaseNeuropeptide Y mRNA in arcuate nucleus
Study
Japanese quailn: not reported in source
7-day-old chicks
Outcome group
Appetite and food intake · Metabolic and weight
Studied dose
Dose not stated · intracerebroventricularAs given in this study (Japanese quail).
Source sentences
Summary
In experiment 4, ICV VIP was associated with decreased neuropeptide Y mRNA in the ARC and DMN and an increase in corticotropin releasing factor mRNA in the DMN.
1 context sentence(design, population, supporting numbers)
Summary · context
The aim of the present study was thus to investigate hypothalamic mechanisms mediating VIP-induced satiety in 7-d old Japanese quail.
Report a problemFND-3285846506
07AnimalAnimal study (in vivo)Mechanism
In Japanese quail, ICV VIP decreased neuropeptide Y mRNA in the dorsomedial nucleus.
In plain wordsIn quail, VIP injected into the brain lowered neuropeptide Y messenger RNA in a second brain area that controls appetite.
Peptide
Vasoactive intestinal peptide (VIP, aviptadil)
Outcome
DecreaseNeuropeptide Y mRNA in dorsomedial nucleus
Study
Japanese quailn: not reported in source
7-day-old chicks
Outcome group
Appetite and food intake · Metabolic and weight
Studied dose
Dose not stated · intracerebroventricularAs given in this study (Japanese quail).
Source sentences
Summary
In experiment 4, ICV VIP was associated with decreased neuropeptide Y mRNA in the ARC and DMN and an increase in corticotropin releasing factor mRNA in the DMN.
1 context sentence(design, population, supporting numbers)
Summary · context
The aim of the present study was thus to investigate hypothalamic mechanisms mediating VIP-induced satiety in 7-d old Japanese quail.
Report a problemFND-3285846507
08AnimalAnimal study (in vivo)Mechanism
In Japanese quail, ICV VIP increased corticotropin releasing factor mRNA in the dorsomedial nucleus.
In plain wordsIn quail, VIP injected into the brain raised corticotropin releasing factor messenger RNA in a brain area that controls appetite.
Peptide
Vasoactive intestinal peptide (VIP, aviptadil)
Outcome
IncreaseCorticotropin releasing factor mRNA in dorsomedial nucleus
Study
Japanese quailn: not reported in source
7-day-old chicks
Outcome group
Appetite and food intake · Metabolic and weight
Studied dose
Dose not stated · intracerebroventricularAs given in this study (Japanese quail).
Source sentences
Summary
In experiment 4, ICV VIP was associated with decreased neuropeptide Y mRNA in the ARC and DMN and an increase in corticotropin releasing factor mRNA in the DMN.
1 context sentence(design, population, supporting numbers)
Summary · context
The aim of the present study was thus to investigate hypothalamic mechanisms mediating VIP-induced satiety in 7-d old Japanese quail.
Report a problemFND-3285846508
09AnimalAnimal study (in vivo)Efficacy outcome
In Japanese quail chicks, VIP-treated chicks displayed fewer feed pecks.
In plain wordsIn young quail, chicks given VIP pecked at feed less often.
Peptide
Vasoactive intestinal peptide (VIP, aviptadil)
Outcome
DecreaseFeed pecks
Study
Japanese quailn: not reported in source
7-day-old chicks
Outcome group
Appetite and food intake · Metabolic and weight
Studied dose
Dose not stated · intracerebroventricularAs given in this study (Japanese quail).
Source sentences
Summary
VIP-treated chicks displayed fewer feed pecks
1 context sentence(design, population, supporting numbers)
Summary · context
The aim of the present study was thus to investigate hypothalamic mechanisms mediating VIP-induced satiety in 7-d old Japanese quail.
Report a problemFND-3285846509
10AnimalAnimal study (in vivo)Efficacy outcome
In Japanese quail chicks, VIP-treated chicks displayed fewer locomotor behaviors.
In plain wordsIn young quail, chicks given VIP moved around less.
Peptide
Vasoactive intestinal peptide (VIP, aviptadil)
Outcome
DecreaseLocomotor behaviors
Study
Japanese quailn: not reported in source
7-day-old chicks
Outcome group
Locomotor and behavioral activity · Nervous system and cognition
Studied dose
Dose not stated · intracerebroventricularAs given in this study (Japanese quail).
Source sentences
Summary
In experiment 5, VIP-treated chicks displayed fewer feed pecks and locomotor behaviors.
1 context sentence(design, population, supporting numbers)
Summary · context
The aim of the present study was thus to investigate hypothalamic mechanisms mediating VIP-induced satiety in 7-d old Japanese quail.
Report a problemFND-3285846510

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
9 Oct 2026, 19:08 UTC
Study results updated
Version 1
9 Oct 2026, 12:40 UTC
First added · source update from Europe PMC

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