Increased expression of IGF-1Ec with increasing colonic polyp dysplasia and colorectal cancer.

Alagaratnam S, Loizidou M, Yang SY, Fuller B, Ramesh B

Journal of cancer research and clinical oncology8 Aug 2020Cited by 8 (Europe PMC)

PMID32772171PMCIDPMC11804673DOI10.1007/s00432-020-03345-0PepBankPUB-32772171

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

No result from this study comes from a test of the peptide.

Natural levels measured5

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

01HumanEndogenous levelObservational studyOther
In patients with colorectal cancer, tissue expression of IGF-1Ec was higher than in normal colonic tissue.
In plain wordsIn people with colorectal cancer, the tumour tissue had more of the body's own IGF-1Ec than normal colon tissue.
Peptide
MGF / PEG-MGF
Outcome
IncreaseIGF-1Ec expression, colorectal cancer versus normal colon
Study
n = 16
Comparator
Normal colonic tissues
Outcome group
Cancer biomarkers and prognosis · Cancer
Source sentences
Summary
Significantly increased expression of IGF-1Ec was demonstrated in colorectal cancer (p < 0.001) and colorectal polyps (p < 0.05) compared to normal colonic tissues.
1 context sentence(design, population, supporting numbers)
Summary · context
Immunohistochemistry was performed in 16 patients with colorectal cancer and 11 patients with colonic polyps and compared to normal colon tissues and prostate adenocarcinoma (positive control) tissues.
This result measures the body's own MGF / PEG-MGF. Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-3277217101
02HumanEndogenous levelObservational studyOther
Lymph node-positive colorectal cancers had lower IGF-1Ec expression than cancers without lymph node metastases at presentation.
In plain wordsColorectal cancers that had spread to lymph nodes showed less of the body's own IGF-1Ec than cancers without spread.
Peptide
MGF / PEG-MGF
Outcome
DecreaseIGF-1Ec expression by lymph node status
Study
n = 16
Comparator
Colorectal cancers without lymph node metastases
Outcome group
Cancer biomarkers and prognosis · Cancer
Source sentences
Summary
Colorectal cancers without lymph node metastases at the time of presentation had significantly higher IGF-1Ec expression compared to lymph node-positive disease (p < 0.05).
1 context sentence(design, population, supporting numbers)
Summary · context
Immunohistochemistry was performed in 16 patients with colorectal cancer and 11 patients with colonic polyps and compared to normal colon tissues and prostate adenocarcinoma (positive control) tissues.
This result measures the body's own MGF / PEG-MGF. Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-3277217104
03HumanEndogenous levelObservational studyOther
IGF-1Ec expression did not correlate with recurrent disease in patients with colorectal cancer.
In plain wordsIn people with colorectal cancer, the body's own IGF-1Ec level was not linked to the disease coming back.
Peptide
MGF / PEG-MGF
Outcome
No significant changeIGF-1Ec expression and recurrent disease
Study
n = 16
Outcome group
Cancer biomarkers and prognosis · Cancer
Source sentences
Summary
No correlation with recurrent disease was identified with IGF-1Ec expression.
1 context sentence(design, population, supporting numbers)
Summary · context
Immunohistochemistry was performed in 16 patients with colorectal cancer and 11 patients with colonic polyps and compared to normal colon tissues and prostate adenocarcinoma (positive control) tissues.
This result measures the body's own MGF / PEG-MGF. Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-3277217105
04HumanEndogenous levelObservational studyOther
In patients with colonic polyps, tissue expression of IGF-1Ec was higher than in normal colonic tissue.
In plain wordsIn people with colonic polyps, the polyp tissue had more of the body's own IGF-1Ec than normal colon tissue.
Peptide
MGF / PEG-MGF
Outcome
IncreaseIGF-1Ec expression, colorectal polyps versus normal colon
Study
n = 11
Comparator
Normal colonic tissues
Outcome group
Cancer biomarkers and prognosis · Cancer
Source sentences
Summary
Significantly increased expression of IGF-1Ec was demonstrated in colorectal cancer (p < 0.001) and colorectal polyps (p < 0.05) compared to normal colonic tissues.
1 context sentence(design, population, supporting numbers)
Summary · context
Immunohistochemistry was performed in 16 patients with colorectal cancer and 11 patients with colonic polyps and compared to normal colon tissues and prostate adenocarcinoma (positive control) tissues.
This result measures the body's own MGF / PEG-MGF. Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-3277217102
05HumanEndogenous levelObservational studyOther
Colonic adenomas with high-grade dysplasia had higher IGF-1Ec expression than low-grade dysplastic adenomas.
In plain wordsColon adenomas with high-grade dysplasia had more of the body's own IGF-1Ec than low-grade adenomas.
Peptide
MGF / PEG-MGF
Outcome
IncreaseIGF-1Ec expression, high-grade versus low-grade dysplastic adenomas
Study
n: not reported in source
Comparator
Low-grade dysplastic adenomas
Outcome group
Cancer biomarkers and prognosis · Cancer
Source sentences
Summary
Colonic adenomas with high-grade dysplasia had significantly higher expression of IGF-1Ec compared to low-grade dysplastic adenomas (p < 0.001).
1 context sentence(design, population, supporting numbers)
Summary · context
Immunohistochemistry was performed in 16 patients with colorectal cancer and 11 patients with colonic polyps and compared to normal colon tissues and prostate adenocarcinoma (positive control) tissues.
This result measures the body's own MGF / PEG-MGF. Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-3277217103

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
13 Oct 2026, 21:44 UTC
Study results updated
Version 1
13 Oct 2026, 16:31 UTC
First added · source update from Europe PMC

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