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Study · Randomized controlled trial · n = 49 · 2020

3 results

Automatic Imitation in Comorbid PTSD & Alcohol Use Disorder and Controls: an RCT of Intranasal Oxytocin.

Morrison TE, De Coster L, Stauffer CS, Wen J, Ahmadi E, Delucchi K, O'Donovan A, Woolley J

Psychoneuroendocrinology4 Jul 2020Cited by 3 (Europe PMC)

PMID32745891 (opens in a new tab)PMCIDPMC7502459 (opens in a new tab)DOI10.1016/j.psyneuen.2020.104787 (opens in a new tab)PepBankPUB-32745891
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. 3 results from people.

  1. 01HumanRandomized controlled trialEfficacy outcome

    In men with comorbid PTSD and alcohol use disorder, intranasal oxytocin did not significantly increase the automatic imitation congruency effect versus placebo.

    In plain wordsIn men with PTSD and alcohol use disorder, oxytocin did not significantly increase automatic imitation compared with placebo.

    Peptide
    Oxytocin
    Outcome
    No significant changeAutomatic imitation congruency effect, PTSD-AUD
    Study

    n = 49

    Comparator
    Placebo
    Outcome group
    Social behavior and cognition · Nervous system and cognition
    Studied dose
    20 IU and 40 IU · intranasalAs given in this study (human).

    Source sentences

    Summary
    In PTSD-AUD, oxytocin did not significantly increase CE.
    2 context sentences
    Summary · context
    After exclusions, the final analyzed data set included 49 participants with PTSD-AUD and 38 HC.
    Summary · context
    Fifty-four males with PTSD-AUD and 43 male HC received three intranasal treatment conditions (placebo, oxytocin 20 International Units (IU), and oxytocin 40 IU) in a randomized order, across three separate testing days, as part of a double-blind, crossover parent study.
  2. 02HumanRandomized controlled trialEfficacy outcome

    In healthy men, intranasal oxytocin 20 IU increased the automatic imitation congruency effect versus placebo.

    In plain wordsIn healthy men, oxytocin at 20 IU increased automatic imitation compared with placebo.

    Peptide
    Oxytocin
    Outcome
    IncreaseAutomatic imitation congruency effect, healthy controls (20 IU)
    Study

    n = 38

    Comparator
    Placebo
    Outcome group
    Social behavior and cognition · Nervous system and cognition
    Studied dose
    20 IU · intranasalAs given in this study (human).

    Source sentences

    Summary
    In HC, oxytocin 20 IU demonstrated a statistically significant increase in CE
    2 context sentences
    Summary · context
    After exclusions, the final analyzed data set included 49 participants with PTSD-AUD and 38 HC.
    Summary · context
    Fifty-four males with PTSD-AUD and 43 male HC received three intranasal treatment conditions (placebo, oxytocin 20 International Units (IU), and oxytocin 40 IU) in a randomized order, across three separate testing days, as part of a double-blind, crossover parent study.
  3. 03HumanRandomized controlled trialEfficacy outcome

    In healthy men, intranasal oxytocin 40 IU showed only a trend-level increase in the automatic imitation congruency effect versus placebo.

    In plain wordsIn healthy men, oxytocin at 40 IU showed only a trend toward more automatic imitation compared with placebo.

    Peptide
    Oxytocin
    Outcome
    No significant changeAutomatic imitation congruency effect, healthy controls (40 IU)
    Study

    n = 38

    Comparator
    Placebo
    Outcome group
    Social behavior and cognition · Nervous system and cognition
    Studied dose
    40 IU · intranasalAs given in this study (human).

    Source sentences

    Summary
    and 40 IU showed a trend-level increase.
    2 context sentences
    Summary · context
    After exclusions, the final analyzed data set included 49 participants with PTSD-AUD and 38 HC.
    Summary · context
    Fifty-four males with PTSD-AUD and 43 male HC received three intranasal treatment conditions (placebo, oxytocin 20 International Units (IU), and oxytocin 40 IU) in a randomized order, across three separate testing days, as part of a double-blind, crossover parent study.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 01:30 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:48 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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