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Study · Randomized controlled trial · n = 48 · 2020

8 results

Oxytocin-enhanced group therapy for methamphetamine use disorder: Randomized controlled trial.

Stauffer CS, Moschetto JM, McKernan S, Meinzer N, Chiang C, Rapier R, Hsiang E, Norona J, Borsari B, Woolley JD

Journal of substance abuse treatment15 Jun 2020Cited by 17 (Europe PMC)

PMID32741502 (opens in a new tab)PMCIDPMC7491413 (opens in a new tab)DOI10.1016/j.jsat.2020.108059 (opens in a new tab)PepBankPUB-32741502
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study8

8 results from studies that gave the peptide. 8 results from people.

  1. 01HumanRandomized controlled trialEfficacy outcome

    In men who have sex with men with methamphetamine use disorder, intranasal oxytocin 40 IU increased group therapy attendance versus placebo.

    In plain wordsIn men with methamphetamine use disorder, oxytocin before group therapy raised attendance compared with placebo.

    Peptide
    Oxytocin
    Outcome
    IncreaseGroup therapy attendance
    Study

    n = 48

    Comparator
    Placebo
    Analysis
    Primary
    Outcome group
    Treatment adherence and retention · Mental health and mood
    Studied dose
    40 IU · intranasal · six weekly sessionsAs given in this study (human).

    Measurements

    OR
    3.26 ratio
    attendance, oxytocin vs placebo

    Source sentences

    Summary
    Participants receiving oxytocin had significantly higher group therapy attendance than those receiving placebo, OR 3.26, 95% CI [1.27-8.41], p = .014.
    1 context sentence
    Summary · context
    This is a randomized, double blind trial of oxytocin 40-IU (n = 24) or placebo (n = 24) administered intranasally prior to each of six weekly motivational interviewing group therapy (MIGT) sessions for MUD in MSM.
  2. 02HumanRandomized controlled trialEfficacy outcome

    In men who have sex with men with methamphetamine use disorder, oxytocin had a small effect on group cohesion versus placebo.

    In plain wordsIn men with methamphetamine use disorder, oxytocin had a small effect on group cohesion compared with placebo.

    Peptide
    Oxytocin
    Outcome
    Direction not reportedGroup cohesion
    Study

    n = 48

    Comparator
    Placebo
    Analysis
    Secondary
    Outcome group
    Treatment adherence and retention · Mental health and mood
    Studied dose
    40 IU · intranasal · six weekly sessionsAs given in this study (human).

    Source sentences

    Summary
    There was a small effect of oxytocin on group cohension, but not anxiety or craving.
    1 context sentence
    Summary · context
    This is a randomized, double blind trial of oxytocin 40-IU (n = 24) or placebo (n = 24) administered intranasally prior to each of six weekly motivational interviewing group therapy (MIGT) sessions for MUD in MSM.
  3. 03HumanRandomized controlled trialEfficacy outcome

    In men who have sex with men with methamphetamine use disorder, oxytocin had no effect on anxiety versus placebo.

    In plain wordsIn men with methamphetamine use disorder, oxytocin did not change anxiety compared with placebo.

    Peptide
    Oxytocin
    Outcome
    No significant changeAnxiety
    Study

    n = 48

    Comparator
    Placebo
    Analysis
    Secondary
    Outcome group
    Anxiety and mood · Mental health and mood
    Studied dose
    40 IU · intranasal · six weekly sessionsAs given in this study (human).

    Source sentences

    Summary
    There was a small effect of oxytocin on group cohension, but not anxiety or craving.
    1 context sentence
    Summary · context
    This is a randomized, double blind trial of oxytocin 40-IU (n = 24) or placebo (n = 24) administered intranasally prior to each of six weekly motivational interviewing group therapy (MIGT) sessions for MUD in MSM.
  4. 04HumanRandomized controlled trialEfficacy outcome

    In men who have sex with men with methamphetamine use disorder, oxytocin had no effect on methamphetamine craving versus placebo.

    In plain wordsIn men with methamphetamine use disorder, oxytocin did not change craving compared with placebo.

    Peptide
    Oxytocin
    Outcome
    No significant changeMethamphetamine craving
    Study

    n = 48

    Comparator
    Placebo
    Analysis
    Secondary
    Outcome group
    Addiction, withdrawal and alcohol intake · Mental health and mood
    Studied dose
    40 IU · intranasal · six weekly sessionsAs given in this study (human).

    Source sentences

    Summary
    There was a small effect of oxytocin on group cohension, but not anxiety or craving.
    1 context sentence
    Summary · context
    This is a randomized, double blind trial of oxytocin 40-IU (n = 24) or placebo (n = 24) administered intranasally prior to each of six weekly motivational interviewing group therapy (MIGT) sessions for MUD in MSM.
  5. 05HumanRandomized controlled trialEfficacy outcome

    In men who have sex with men with methamphetamine use disorder, methamphetamine use did not change over six weeks in either the oxytocin or the placebo arm.

    In plain wordsIn men with methamphetamine use disorder, methamphetamine use did not change over six weeks with oxytocin or with placebo.

    Peptide
    Oxytocin
    Outcome
    No significant changeMethamphetamine use
    Study

    n = 48

    Comparator
    Placebo
    Analysis
    Secondary
    Outcome group
    Addiction, withdrawal and alcohol intake · Mental health and mood
    Studied dose
    40 IU · intranasal · six weekly sessionsAs given in this study (human).

    Source sentences

    Summary
    METH use did not change over the six-week MIGT course in either treatment arm.
    1 context sentence
    Summary · context
    This is a randomized, double blind trial of oxytocin 40-IU (n = 24) or placebo (n = 24) administered intranasally prior to each of six weekly motivational interviewing group therapy (MIGT) sessions for MUD in MSM.
  6. 06HumanRandomized controlled trialEfficacy outcome

    In men who have sex with men with methamphetamine use disorder, oxytocin lowered average heart rate during therapy sessions versus placebo.

    In plain wordsIn men with methamphetamine use disorder, oxytocin lowered average heart rate during therapy sessions compared with placebo.

    Peptide
    Oxytocin
    Outcome
    DecreaseAverage heart rate during sessions
    Study

    n = 48

    Comparator
    Placebo
    Analysis
    Secondary
    Outcome group
    Heart function · Cardiovascular
    Studied dose
    40 IU · intranasal · six weekly sessionsAs given in this study (human).

    Source sentences

    Summary
    Participants receiving oxytocin had lower average heart rates during MIGT sessions
    1 context sentence
    Summary · context
    This is a randomized, double blind trial of oxytocin 40-IU (n = 24) or placebo (n = 24) administered intranasally prior to each of six weekly motivational interviewing group therapy (MIGT) sessions for MUD in MSM.
  7. 07HumanRandomized controlled trialEfficacy outcome

    In men who have sex with men with methamphetamine use disorder, oxytocin increased heart rate variability during therapy sessions versus placebo.

    In plain wordsIn men with methamphetamine use disorder, oxytocin raised heart rate variability during therapy sessions compared with placebo.

    Peptide
    Oxytocin
    Outcome
    IncreaseHeart rate variability during sessions
    Study

    n = 48

    Comparator
    Placebo
    Analysis
    Secondary
    Outcome group
    Heart function · Cardiovascular
    Studied dose
    40 IU · intranasal · six weekly sessionsAs given in this study (human).

    Source sentences

    Summary
    Participants receiving oxytocin had lower average heart rates during MIGT sessions and higher heart rate variability.
    1 context sentence
    Summary · context
    This is a randomized, double blind trial of oxytocin 40-IU (n = 24) or placebo (n = 24) administered intranasally prior to each of six weekly motivational interviewing group therapy (MIGT) sessions for MUD in MSM.
  8. 08HumanRandomized controlled trialSafety outcome

    In men who have sex with men with methamphetamine use disorder, no serious adverse events were reported with oxytocin.

    In plain wordsIn men with methamphetamine use disorder, no serious side effects were reported with oxytocin.

    Peptide
    Oxytocin
    Outcome
    No significant changeSerious adverse events
    Study

    n = 48

    Comparator
    Placebo
    Outcome group
    Adverse events · Whole body
    Studied dose
    40 IU · intranasal · six weekly sessionsAs given in this study (human).

    Source sentences

    Summary
    This evidence, and the lack of any serious adverse events
    1 context sentence
    Summary · context
    This is a randomized, double blind trial of oxytocin 40-IU (n = 24) or placebo (n = 24) administered intranasally prior to each of six weekly motivational interviewing group therapy (MIGT) sessions for MUD in MSM.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 01:30 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:48 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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