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Study · Animal study (in vivo) · rat · 2020

10 results

Improvement in cognitive dysfunction following blast induced traumatic brain injury by thymosin α1 in rats: Involvement of inhibition of tau phosphorylation at the Thr205 epitope.

Shi QX, Chen B, Nie C, Zhao ZP, Zhang JH, Si SY, Cui SJ, Gu JW

Brain research30 Jul 2020Cited by 5 (Europe PMC)

PMID32738231 (opens in a new tab)DOI10.1016/j.brainres.2020.147038 (opens in a new tab)PepBankPUB-32738231
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study10

10 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In rats with blast-induced traumatic brain injury, thymosin α1 seemed to reduce 24-hour mortality, but the difference was not statistically significant.

    In plain wordsIn rats with blast brain injury, thymosin α1 did not significantly change deaths within 24 hours compared with saline.

    Peptide
    Thymosin alpha-1
    Outcome
    No significant change24-hour mortality
    Study

    ratn: not reported in source

    Blast-induced traumatic brain injury
    Comparator
    Normal saline
    Outcome group
    Mortality · Nervous system and cognition
    Studied dose
    200 µg/kg, twice a day · 3 days or 2 weeksAs given in this study (rat).

    Source sentences

    Summary
    Tα1 treatment seemed to reduce the 24-hour mortality, albeit with no statistical significance.
    2 context sentences
    Summary · context
    The blast induced TBI (bTBI) rat model was established with the compressed gas driven blast injury model system.
    Summary · context
    A consecutive Tα1 therapy (in 1 ml saline, twice a day) at a dose of 200 µg/kg or normal saline (NS) (1 ml, twice a day) for 3 days or 2 weeks was performed.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In rats with blast-induced traumatic brain injury, thymosin α1 decreased the escape latency in the acquisition phase of the Morris water maze.

    In plain wordsIn rats with blast brain injury, thymosin α1 helped them find the maze platform faster than saline.

    Peptide
    Thymosin alpha-1
    Outcome
    DecreaseEscape latency in Morris water maze acquisition phase
    Study

    ratn: not reported in source

    Blast-induced traumatic brain injury
    Comparator
    Normal saline
    Outcome group
    Cognition and memory · Nervous system and cognition
    Studied dose
    200 µg/kg, twice a day · 3 days or 2 weeksAs given in this study (rat).

    Source sentences

    Summary
    Moreover, Tα1 treatment markedly improved cognitive dysfunction by decreasing the escape latency in the acquisition phase, and increasing the crossing numbers in the probe phase of MWM test.
    2 context sentences
    Summary · context
    The blast induced TBI (bTBI) rat model was established with the compressed gas driven blast injury model system.
    Summary · context
    A consecutive Tα1 therapy (in 1 ml saline, twice a day) at a dose of 200 µg/kg or normal saline (NS) (1 ml, twice a day) for 3 days or 2 weeks was performed.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In rats with blast-induced traumatic brain injury, thymosin α1 increased the crossing numbers in the probe phase of the Morris water maze.

    In plain wordsIn rats with blast brain injury, thymosin α1 raised the number of platform crossings in the memory test compared with saline.

    Peptide
    Thymosin alpha-1
    Outcome
    IncreaseCrossing numbers in Morris water maze probe phase
    Study

    ratn: not reported in source

    Blast-induced traumatic brain injury
    Comparator
    Normal saline
    Outcome group
    Cognition and memory · Nervous system and cognition
    Studied dose
    200 µg/kg, twice a day · 3 days or 2 weeksAs given in this study (rat).

    Source sentences

    Summary
    Moreover, Tα1 treatment markedly improved cognitive dysfunction by decreasing the escape latency in the acquisition phase, and increasing the crossing numbers in the probe phase of MWM test.
    2 context sentences
    Summary · context
    The blast induced TBI (bTBI) rat model was established with the compressed gas driven blast injury model system.
    Summary · context
    A consecutive Tα1 therapy (in 1 ml saline, twice a day) at a dose of 200 µg/kg or normal saline (NS) (1 ml, twice a day) for 3 days or 2 weeks was performed.
  4. 04AnimalAnimal study (in vivo)Mechanism

    In rats with blast-induced traumatic brain injury, thymosin α1 inhibited tau phosphorylation at the Thr205 epitope.

    In plain wordsIn rats with blast brain injury, thymosin α1 lowered a tau protein change linked to brain damage.

    Peptide
    Thymosin alpha-1
    Outcome
    DecreaseTau phosphorylation at Thr205
    Study

    ratn: not reported in source

    Blast-induced traumatic brain injury
    Comparator
    Normal saline
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    200 µg/kg, twice a day · 3 days or 2 weeksAs given in this study (rat).

    Source sentences

    Summary
    Tα1 significantly inhibited tau phosphorylation at the Thr205 epitope
    2 context sentences
    Summary · context
    The blast induced TBI (bTBI) rat model was established with the compressed gas driven blast injury model system.
    Summary · context
    A consecutive Tα1 therapy (in 1 ml saline, twice a day) at a dose of 200 µg/kg or normal saline (NS) (1 ml, twice a day) for 3 days or 2 weeks was performed.
  5. 05AnimalAnimal study (in vivo)Mechanism

    In rats with blast-induced traumatic brain injury, thymosin α1 did not inhibit tau phosphorylation at the Ser404 epitope.

    In plain wordsIn rats with blast brain injury, thymosin α1 did not change tau phosphorylation at the Ser404 site.

    Peptide
    Thymosin alpha-1
    Outcome
    No significant changeTau phosphorylation at Ser404
    Study

    ratn: not reported in source

    Blast-induced traumatic brain injury
    Comparator
    Normal saline
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    200 µg/kg, twice a day · 3 days or 2 weeksAs given in this study (rat).

    Source sentences

    Summary
    More interestingly, Tα1 significantly inhibited tau phosphorylation at the Thr205 epitope, but not at the Ser404 and Ser262 epitopes.
    2 context sentences
    Summary · context
    The blast induced TBI (bTBI) rat model was established with the compressed gas driven blast injury model system.
    Summary · context
    A consecutive Tα1 therapy (in 1 ml saline, twice a day) at a dose of 200 µg/kg or normal saline (NS) (1 ml, twice a day) for 3 days or 2 weeks was performed.
  6. 06AnimalAnimal study (in vivo)Mechanism

    In rats with blast-induced traumatic brain injury, thymosin α1 did not inhibit tau phosphorylation at the Ser262 epitope.

    In plain wordsIn rats with blast brain injury, thymosin α1 did not change tau phosphorylation at the Ser262 site.

    Peptide
    Thymosin alpha-1
    Outcome
    No significant changeTau phosphorylation at Ser262
    Study

    ratn: not reported in source

    Blast-induced traumatic brain injury
    Comparator
    Normal saline
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    200 µg/kg, twice a day · 3 days or 2 weeksAs given in this study (rat).

    Source sentences

    Summary
    More interestingly, Tα1 significantly inhibited tau phosphorylation at the Thr205 epitope, but not at the Ser404 and Ser262 epitopes.
    2 context sentences
    Summary · context
    The blast induced TBI (bTBI) rat model was established with the compressed gas driven blast injury model system.
    Summary · context
    A consecutive Tα1 therapy (in 1 ml saline, twice a day) at a dose of 200 µg/kg or normal saline (NS) (1 ml, twice a day) for 3 days or 2 weeks was performed.
  7. 07AnimalAnimal study (in vivo)Mechanism

    In rats with blast-induced traumatic brain injury, thymosin α1 increased the percentage of Treg cells on day 3 after injury.

    In plain wordsIn rats with blast brain injury, thymosin α1 raised the share of regulatory T cells compared with saline.

    Peptide
    Thymosin alpha-1
    Outcome
    IncreasePercentage of Treg cells
    Study

    ratn: not reported in source

    Blast-induced traumatic brain injury
    Comparator
    Normal saline
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    200 µg/kg, twice a day · 3 days or 2 weeksAs given in this study (rat).

    Source sentences

    Summary
    Tα1 increased the percentage of Treg cells
    2 context sentences
    Summary · context
    The blast induced TBI (bTBI) rat model was established with the compressed gas driven blast injury model system.
    Summary · context
    A consecutive Tα1 therapy (in 1 ml saline, twice a day) at a dose of 200 µg/kg or normal saline (NS) (1 ml, twice a day) for 3 days or 2 weeks was performed.
  8. 08AnimalAnimal study (in vivo)Efficacy outcome

    In rats with blast-induced traumatic brain injury, thymosin α1 inhibited plasma IL-6 production on day 3 after injury.

    In plain wordsIn rats with blast brain injury, thymosin α1 lowered the blood level of the inflammation marker IL-6 compared with saline.

    Peptide
    Thymosin alpha-1
    Outcome
    DecreasePlasma IL-6
    Study

    ratn: not reported in source

    Blast-induced traumatic brain injury
    Comparator
    Normal saline
    Outcome group
    Inflammation markers · Immune and inflammation
    Studied dose
    200 µg/kg, twice a day · 3 days or 2 weeksAs given in this study (rat).

    Source sentences

    Summary
    inhibited plasma IL-6 production on 3d post bTBI.
    2 context sentences
    Summary · context
    The blast induced TBI (bTBI) rat model was established with the compressed gas driven blast injury model system.
    Summary · context
    A consecutive Tα1 therapy (in 1 ml saline, twice a day) at a dose of 200 µg/kg or normal saline (NS) (1 ml, twice a day) for 3 days or 2 weeks was performed.
  9. 09AnimalAnimal study (in vivo)Efficacy outcome

    In rats with blast-induced traumatic brain injury, thymosin α1 suppressed brain edema, shown by lower brain water content.

    In plain wordsIn rats with blast brain injury, thymosin α1 reduced brain swelling compared with saline.

    Peptide
    Thymosin alpha-1
    Outcome
    DecreaseBrain edema (brain water content)
    Study

    ratn: not reported in source

    Blast-induced traumatic brain injury
    Comparator
    Normal saline
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    200 µg/kg, twice a day · 3 days or 2 weeksAs given in this study (rat).

    Source sentences

    Summary
    Moreover, Tα1 suppressed brain edema as demonstrated by decrease of BWC.
    2 context sentences
    Summary · context
    The blast induced TBI (bTBI) rat model was established with the compressed gas driven blast injury model system.
    Summary · context
    A consecutive Tα1 therapy (in 1 ml saline, twice a day) at a dose of 200 µg/kg or normal saline (NS) (1 ml, twice a day) for 3 days or 2 weeks was performed.
  10. 10AnimalAnimal study (in vivo)Efficacy outcome

    In rats with blast-induced traumatic brain injury, thymosin α1 did not obviously change brain histopathology.

    In plain wordsIn rats with blast brain injury, thymosin α1 did not obviously change how the brain tissue looked under the microscope.

    Peptide
    Thymosin alpha-1
    Outcome
    No significant changeBrain histopathology
    Study

    ratn: not reported in source

    Blast-induced traumatic brain injury
    Comparator
    Normal saline
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    200 µg/kg, twice a day · 3 days or 2 weeksAs given in this study (rat).

    Source sentences

    Summary
    However, there was a lack of obvious change in histopathology in the brain upon Tα1 treatment.
    2 context sentences
    Summary · context
    The blast induced TBI (bTBI) rat model was established with the compressed gas driven blast injury model system.
    Summary · context
    A consecutive Tα1 therapy (in 1 ml saline, twice a day) at a dose of 200 µg/kg or normal saline (NS) (1 ml, twice a day) for 3 days or 2 weeks was performed.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    10 Oct 2026, 08:55 UTC

    Study results updated

  2. Version 2

    9 Oct 2026, 03:03 UTC

    Study data updated · source update from Europe PMC

  3. Version 1

    9 Oct 2026, 03:02 UTC

    First added · source update from Europe PMC

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