Skip to content

Study · Animal study (in vivo) · mouse · 2020

16 results

Pharmaceutical grade synthetic peptide Thr-Glu-Lys-Lys-Arg-Arg-Glu-Thr-Val-Glu-Arg-Glu-Lys-Glu ameliorates DSS-induced murine colitis by reducing the number and pro-inflammatory activity of colon tissue-infiltrating Ly6G+ granulocytes and Ly6C+ monocytes.

Chulkina MM, Pichugin AV, Ataullakhanov RI

Peptides1 Jul 2020Cited by 9 (Europe PMC)

PMID32621844 (opens in a new tab)DOI10.1016/j.peptides.2020.170364 (opens in a new tab)PepBankPUB-32621844
Publisher pagePubMedAsk about this study
Jump to 16 results

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study16

16 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In mice with DSS colitis, GEPON significantly attenuated pathological manifestations in the large intestine.

    In plain wordsIn mice with DSS colitis, GEPON reduced signs of disease in the large intestine.

    Peptide
    Gepon
    Outcome
    DecreaseLarge-intestine pathological manifestations
    Study

    mousen: not reported in source

    DSS colitis in C57BL/6 mice
    Outcome group
    Gastrointestinal protection · Gastrointestinal
    Studied dose
    Dose not stated · intraperitonealAs given in this study (mouse).

    Source sentences

    Summary
    We report that GEPON intraperitoneal injections significantly attenuated DSS-induced pathological manifestations in the large intestine, bloody diarrhoea, and body weight loss in C57BL/6 mice.
    1 context sentence
    Summary · context
    A pharmaceutical grade synthetic tetradecapeptide Thr-Glu-Lys-Lys-Arg-Arg-Glu-Thr-Val-Glu-Arg-Glu-Lys-Glu (GEPON) that mimics the ezrin protein hinge region was studied in dextran sodium sulphate-induced murine experimental colitis (DSS colitis).
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In mice with DSS colitis, GEPON significantly attenuated bloody diarrhoea.

    In plain wordsIn mice with DSS colitis, GEPON reduced bloody diarrhoea.

    Peptide
    Gepon
    Outcome
    DecreaseBloody diarrhoea
    Study

    mousen: not reported in source

    DSS colitis in C57BL/6 mice
    Outcome group
    Gastrointestinal protection · Gastrointestinal
    Studied dose
    Dose not stated · intraperitonealAs given in this study (mouse).

    Source sentences

    Summary
    We report that GEPON intraperitoneal injections significantly attenuated DSS-induced pathological manifestations in the large intestine, bloody diarrhoea, and body weight loss in C57BL/6 mice.
    1 context sentence
    Summary · context
    A pharmaceutical grade synthetic tetradecapeptide Thr-Glu-Lys-Lys-Arg-Arg-Glu-Thr-Val-Glu-Arg-Glu-Lys-Glu (GEPON) that mimics the ezrin protein hinge region was studied in dextran sodium sulphate-induced murine experimental colitis (DSS colitis).
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In mice with DSS colitis, GEPON significantly attenuated body weight loss.

    In plain wordsIn mice with DSS colitis, GEPON reduced weight loss.

    Peptide
    Gepon
    Outcome
    DecreaseBody weight loss
    Study

    mousen: not reported in source

    DSS colitis in C57BL/6 mice
    Outcome group
    Body weight · Metabolic and weight
    Studied dose
    Dose not stated · intraperitonealAs given in this study (mouse).

    Source sentences

    Summary
    We report that GEPON intraperitoneal injections significantly attenuated DSS-induced pathological manifestations in the large intestine, bloody diarrhoea, and body weight loss in C57BL/6 mice.
    1 context sentence
    Summary · context
    A pharmaceutical grade synthetic tetradecapeptide Thr-Glu-Lys-Lys-Arg-Arg-Glu-Thr-Val-Glu-Arg-Glu-Lys-Glu (GEPON) that mimics the ezrin protein hinge region was studied in dextran sodium sulphate-induced murine experimental colitis (DSS colitis).
  4. 04AnimalAnimal study (in vivo)Mechanism

    In mice with DSS colitis, GEPON markedly inhibited Il1b transcription in colon tissue.

    In plain wordsIn mice with DSS colitis, GEPON reduced Il1b gene activity in colon tissue.

    Peptide
    Gepon
    Outcome
    DecreaseColon Il1b transcription
    Study

    mousen: not reported in source

    DSS colitis in C57BL/6 mice
    Outcome group
    Inflammation markers · Immune and inflammation
    Studied dose
    Dose not stated · intraperitonealAs given in this study (mouse).

    Source sentences

    Summary
    GEPON markedly inhibited the transcription rate of pro-inflammatory Il1b, Il6, and Nos2 genes in the colon tissue, in contrast with those encoding anti-inflammatory factors, such as Tgfb1, I10, and Arg1, whose transcription rate did not change significantly.
    1 context sentence
    Summary · context
    A pharmaceutical grade synthetic tetradecapeptide Thr-Glu-Lys-Lys-Arg-Arg-Glu-Thr-Val-Glu-Arg-Glu-Lys-Glu (GEPON) that mimics the ezrin protein hinge region was studied in dextran sodium sulphate-induced murine experimental colitis (DSS colitis).
  5. 05AnimalAnimal study (in vivo)Mechanism

    In mice with DSS colitis, GEPON markedly inhibited Il6 transcription in colon tissue.

    In plain wordsIn mice with DSS colitis, GEPON reduced Il6 gene activity in colon tissue.

    Peptide
    Gepon
    Outcome
    DecreaseColon Il6 transcription
    Study

    mousen: not reported in source

    DSS colitis in C57BL/6 mice
    Outcome group
    Inflammation markers · Immune and inflammation
    Studied dose
    Dose not stated · intraperitonealAs given in this study (mouse).

    Source sentences

    Summary
    GEPON markedly inhibited the transcription rate of pro-inflammatory Il1b, Il6, and Nos2 genes in the colon tissue, in contrast with those encoding anti-inflammatory factors, such as Tgfb1, I10, and Arg1, whose transcription rate did not change significantly.
    1 context sentence
    Summary · context
    A pharmaceutical grade synthetic tetradecapeptide Thr-Glu-Lys-Lys-Arg-Arg-Glu-Thr-Val-Glu-Arg-Glu-Lys-Glu (GEPON) that mimics the ezrin protein hinge region was studied in dextran sodium sulphate-induced murine experimental colitis (DSS colitis).
  6. 06AnimalAnimal study (in vivo)Mechanism

    In mice with DSS colitis, GEPON markedly inhibited Nos2 transcription in colon tissue.

    In plain wordsIn mice with DSS colitis, GEPON reduced Nos2 gene activity in colon tissue.

    Peptide
    Gepon
    Outcome
    DecreaseColon Nos2 transcription
    Study

    mousen: not reported in source

    DSS colitis in C57BL/6 mice
    Outcome group
    Inflammation markers · Immune and inflammation
    Studied dose
    Dose not stated · intraperitonealAs given in this study (mouse).

    Source sentences

    Summary
    GEPON markedly inhibited the transcription rate of pro-inflammatory Il1b, Il6, and Nos2 genes in the colon tissue, in contrast with those encoding anti-inflammatory factors, such as Tgfb1, I10, and Arg1, whose transcription rate did not change significantly.
    1 context sentence
    Summary · context
    A pharmaceutical grade synthetic tetradecapeptide Thr-Glu-Lys-Lys-Arg-Arg-Glu-Thr-Val-Glu-Arg-Glu-Lys-Glu (GEPON) that mimics the ezrin protein hinge region was studied in dextran sodium sulphate-induced murine experimental colitis (DSS colitis).
  7. 07AnimalAnimal study (in vivo)Mechanism

    In mice with DSS colitis, GEPON did not significantly change Tgfb1 transcription in colon tissue.

    In plain wordsIn mice with DSS colitis, GEPON did not significantly change Tgfb1 gene activity in colon tissue.

    Peptide
    Gepon
    Outcome
    No significant changeColon Tgfb1 transcription
    Study

    mousen: not reported in source

    DSS colitis in C57BL/6 mice
    Outcome group
    Inflammation markers · Immune and inflammation
    Studied dose
    Dose not stated · intraperitonealAs given in this study (mouse).

    Source sentences

    Summary
    GEPON markedly inhibited the transcription rate of pro-inflammatory Il1b, Il6, and Nos2 genes in the colon tissue, in contrast with those encoding anti-inflammatory factors, such as Tgfb1, I10, and Arg1, whose transcription rate did not change significantly.
    1 context sentence
    Summary · context
    A pharmaceutical grade synthetic tetradecapeptide Thr-Glu-Lys-Lys-Arg-Arg-Glu-Thr-Val-Glu-Arg-Glu-Lys-Glu (GEPON) that mimics the ezrin protein hinge region was studied in dextran sodium sulphate-induced murine experimental colitis (DSS colitis).
  8. 08AnimalAnimal study (in vivo)Mechanism

    In mice with DSS colitis, GEPON did not significantly change I10 transcription in colon tissue.

    In plain wordsIn mice with DSS colitis, GEPON did not significantly change I10 gene activity in colon tissue.

    Peptide
    Gepon
    Outcome
    No significant changeColon I10 transcription
    Study

    mousen: not reported in source

    DSS colitis in C57BL/6 mice
    Outcome group
    Inflammation markers · Immune and inflammation
    Studied dose
    Dose not stated · intraperitonealAs given in this study (mouse).

    Source sentences

    Summary
    GEPON markedly inhibited the transcription rate of pro-inflammatory Il1b, Il6, and Nos2 genes in the colon tissue, in contrast with those encoding anti-inflammatory factors, such as Tgfb1, I10, and Arg1, whose transcription rate did not change significantly.
    1 context sentence
    Summary · context
    A pharmaceutical grade synthetic tetradecapeptide Thr-Glu-Lys-Lys-Arg-Arg-Glu-Thr-Val-Glu-Arg-Glu-Lys-Glu (GEPON) that mimics the ezrin protein hinge region was studied in dextran sodium sulphate-induced murine experimental colitis (DSS colitis).
  9. 09AnimalAnimal study (in vivo)Mechanism

    In mice with DSS colitis, GEPON did not significantly change Arg1 transcription in colon tissue.

    In plain wordsIn mice with DSS colitis, GEPON did not significantly change Arg1 gene activity in colon tissue.

    Peptide
    Gepon
    Outcome
    No significant changeColon Arg1 transcription
    Study

    mousen: not reported in source

    DSS colitis in C57BL/6 mice
    Outcome group
    Inflammation markers · Immune and inflammation
    Studied dose
    Dose not stated · intraperitonealAs given in this study (mouse).

    Source sentences

    Summary
    GEPON markedly inhibited the transcription rate of pro-inflammatory Il1b, Il6, and Nos2 genes in the colon tissue, in contrast with those encoding anti-inflammatory factors, such as Tgfb1, I10, and Arg1, whose transcription rate did not change significantly.
    1 context sentence
    Summary · context
    A pharmaceutical grade synthetic tetradecapeptide Thr-Glu-Lys-Lys-Arg-Arg-Glu-Thr-Val-Glu-Arg-Glu-Lys-Glu (GEPON) that mimics the ezrin protein hinge region was studied in dextran sodium sulphate-induced murine experimental colitis (DSS colitis).
  10. 10AnimalAnimal study (in vivo)Mechanism

    In mice with DSS colitis, GEPON significantly reduced Ly6G-positive granulocyte accumulation in the colon infiltrate.

    In plain wordsIn mice with DSS colitis, GEPON reduced accumulation of Ly6G-positive granulocytes in the colon.

    Peptide
    Gepon
    Outcome
    DecreaseColon Ly6G-positive granulocyte accumulation
    Study

    mousen: not reported in source

    DSS colitis in C57BL/6 mice
    Outcome group
    Inflammation markers · Immune and inflammation
    Studied dose
    Dose not stated · intraperitonealAs given in this study (mouse).

    Source sentences

    Summary
    Using flow cytometry, we found that GEPON treatment significantly reduced the accumulation of Ly6G+ granulocytes and Ly6C+ monocytes in the colon infiltrate of DSS colitis mice.
    1 context sentence
    Summary · context
    A pharmaceutical grade synthetic tetradecapeptide Thr-Glu-Lys-Lys-Arg-Arg-Glu-Thr-Val-Glu-Arg-Glu-Lys-Glu (GEPON) that mimics the ezrin protein hinge region was studied in dextran sodium sulphate-induced murine experimental colitis (DSS colitis).
  11. 11AnimalAnimal study (in vivo)Mechanism

    In mice with DSS colitis, GEPON significantly reduced Ly6C-positive monocyte accumulation in the colon infiltrate.

    In plain wordsIn mice with DSS colitis, GEPON reduced accumulation of Ly6C-positive monocytes in the colon.

    Peptide
    Gepon
    Outcome
    DecreaseColon Ly6C-positive monocyte accumulation
    Study

    mousen: not reported in source

    DSS colitis in C57BL/6 mice
    Outcome group
    Inflammation markers · Immune and inflammation
    Studied dose
    Dose not stated · intraperitonealAs given in this study (mouse).

    Source sentences

    Summary
    Using flow cytometry, we found that GEPON treatment significantly reduced the accumulation of Ly6G+ granulocytes and Ly6C+ monocytes in the colon infiltrate of DSS colitis mice.
    1 context sentence
    Summary · context
    A pharmaceutical grade synthetic tetradecapeptide Thr-Glu-Lys-Lys-Arg-Arg-Glu-Thr-Val-Glu-Arg-Glu-Lys-Glu (GEPON) that mimics the ezrin protein hinge region was studied in dextran sodium sulphate-induced murine experimental colitis (DSS colitis).
  12. 12AnimalAnimal study (in vivo)Mechanism

    In mice with DSS colitis, GEPON decreased pro-inflammatory gene expression in colon-infiltrating Ly6G-positive granulocytes.

    In plain wordsIn mice with DSS colitis, GEPON reduced inflammatory gene activity in colon-infiltrating granulocytes.

    Peptide
    Gepon
    Outcome
    DecreaseGranulocyte pro-inflammatory gene expression
    Study

    mousen: not reported in source

    DSS colitis in C57BL/6 mice
    Outcome group
    Inflammation markers · Immune and inflammation
    Studied dose
    Dose not stated · intraperitonealAs given in this study (mouse).

    Source sentences

    Summary
    Analysis of the mRNA level in myeloid cells sorted from the colon tissue revealed that GEPON had decreased the expression of pro-inflammatory genes in both colon-infiltrating Ly6G+ granulocytes and Ly6C+ monocytes, but not in Ly6C-CD64+ macrophages of DSS-treated mice.
    1 context sentence
    Summary · context
    A pharmaceutical grade synthetic tetradecapeptide Thr-Glu-Lys-Lys-Arg-Arg-Glu-Thr-Val-Glu-Arg-Glu-Lys-Glu (GEPON) that mimics the ezrin protein hinge region was studied in dextran sodium sulphate-induced murine experimental colitis (DSS colitis).
  13. 13AnimalAnimal study (in vivo)Mechanism

    In mice with DSS colitis, GEPON decreased pro-inflammatory gene expression in colon-infiltrating Ly6C-positive monocytes.

    In plain wordsIn mice with DSS colitis, GEPON reduced inflammatory gene activity in colon-infiltrating monocytes.

    Peptide
    Gepon
    Outcome
    DecreaseMonocyte pro-inflammatory gene expression
    Study

    mousen: not reported in source

    DSS colitis in C57BL/6 mice
    Outcome group
    Inflammation markers · Immune and inflammation
    Studied dose
    Dose not stated · intraperitonealAs given in this study (mouse).

    Source sentences

    Summary
    Analysis of the mRNA level in myeloid cells sorted from the colon tissue revealed that GEPON had decreased the expression of pro-inflammatory genes in both colon-infiltrating Ly6G+ granulocytes and Ly6C+ monocytes, but not in Ly6C-CD64+ macrophages of DSS-treated mice.
    1 context sentence
    Summary · context
    A pharmaceutical grade synthetic tetradecapeptide Thr-Glu-Lys-Lys-Arg-Arg-Glu-Thr-Val-Glu-Arg-Glu-Lys-Glu (GEPON) that mimics the ezrin protein hinge region was studied in dextran sodium sulphate-induced murine experimental colitis (DSS colitis).
  14. 14AnimalAnimal study (in vivo)Mechanism

    In DSS-treated mice, GEPON did not decrease pro-inflammatory gene expression in Ly6C-negative CD64-positive macrophages.

    In plain wordsIn mice with DSS colitis, GEPON did not reduce inflammatory gene activity in the specified macrophages.

    Peptide
    Gepon
    Outcome
    No significant changeMacrophage pro-inflammatory gene expression
    Study

    mousen: not reported in source

    DSS colitis in C57BL/6 mice
    Outcome group
    Inflammation markers · Immune and inflammation
    Studied dose
    Dose not stated · intraperitonealAs given in this study (mouse).

    Source sentences

    Summary
    Analysis of the mRNA level in myeloid cells sorted from the colon tissue revealed that GEPON had decreased the expression of pro-inflammatory genes in both colon-infiltrating Ly6G+ granulocytes and Ly6C+ monocytes, but not in Ly6C-CD64+ macrophages of DSS-treated mice.
    1 context sentence
    Summary · context
    A pharmaceutical grade synthetic tetradecapeptide Thr-Glu-Lys-Lys-Arg-Arg-Glu-Thr-Val-Glu-Arg-Glu-Lys-Glu (GEPON) that mimics the ezrin protein hinge region was studied in dextran sodium sulphate-induced murine experimental colitis (DSS colitis).
  15. 15LabIn vitro (cells)Mechanism

    In cultured Ly6C-positive monocytes, GEPON inhibited IL-1 beta mRNA expression.

    In plain wordsIn cells, GEPON reduced IL-1 beta gene expression in cultured monocytes.

    Peptide
    Gepon
    Outcome
    DecreaseMonocyte IL-1 beta mRNA expression
    Study

    mousen: not reported in source

    In vitro Ly6C-positive monocyte culture
    Outcome group
    Inflammation markers · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The direct anti-inflammatory impact of GEPON was shown in an in vitro culture of Ly6C+ monocytes, as evidenced by an inhibition of IL-1 beta and IL-6 mRNA expression.
  16. 16LabIn vitro (cells)Mechanism

    In cultured Ly6C-positive monocytes, GEPON inhibited IL-6 mRNA expression.

    In plain wordsIn cells, GEPON reduced IL-6 gene expression in cultured monocytes.

    Peptide
    Gepon
    Outcome
    DecreaseMonocyte IL-6 mRNA expression
    Study

    mousen: not reported in source

    In vitro Ly6C-positive monocyte culture
    Outcome group
    Inflammation markers · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The direct anti-inflammatory impact of GEPON was shown in an in vitro culture of Ly6C+ monocytes, as evidenced by an inhibition of IL-1 beta and IL-6 mRNA expression.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    27 Oct 2026, 18:20 UTC

    Study results updated

  2. Version 1

    27 Oct 2026, 16:32 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

PepBank is a research reference. Talk to a doctor before you use any peptide.