In rats under social stress, Selank reduced serum IL-1β concentration, practically reaching control values.
In plain wordsIn rats under social stress, Selank lowered the blood level of the inflammation marker IL-1β.
- Peptide
- Selank
- Outcome
- DecreaseSerum IL-1β under social stress
- Study
ratn: not reported in source
Social stress (sensory contact) model- Comparator
- Stressed rats without Selank
- Outcome group
- Inflammation markers · Immune and inflammation
- Studied dose
- 100 mcg/kg/day · intraperitoneal · 20 daysAs given in this study (rat).
Source sentences
This peptide is able to reduce the concentration of IL-1β, IL-6 and TNF-α, as well as TGF-β1, practically reaching control values, when studying the effect of Selank on the level of cytokines under conditions of " social" stress.
3 context sentences(design, population, supporting numbers)
Evaluation of the effect of Semax on the level of the cytokines in a stress-induced state showed that this neuropeptide causes a decrease in the concentration of IL-1β and IL-6, restoration of the level of IL-4, as well as suppression of the production of TGF-β1 and TNF-α in these conditions.
White nonlinear rats were used as experimental animals.
Laboratory animals were divided into 3 groups: a group of intact males, a group of animals that were subjected to stress (sensory contact) for 20 days and a group that received intraperitoneally Selank at a dose of 100 mcg/kg/day under conditions of 20-day stress.