In mice with established asthma, nanoparticle-delivered thymulin plasmids normalized chronic lung inflammation twenty days after treatment.
In plain wordsIn mice with established asthma, thymulin gene therapy normalized chronic lung inflammation.
- Outcome
- DecreaseChronic lung inflammation
- Study
mousen: not reported in source
Established allergic asthma- Outcome group
- Inflammation markers · Respiratory
Source sentences
Twenty days after the treatment, we found that all key pathologic features found in the asthmatic lung, including chronic inflammation, pulmonary fibrosis, and mechanical dysregulation, were normalized.
1 context sentence(design, population, supporting numbers)
After the disease was fully and stably established, we treated mice intratracheally with a single dose of thymulin-expressing plasmids delivered via nanoparticles engineered to have a unique ability to penetrate the airway mucus barrier.
In this study, Thymulin (serum thymic factor) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymulin (serum thymic factor).