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Study · Animal study (in vivo) · sheep · 2020

4 results

Coronary vascular growth matches IGF-1-stimulated cardiac growth in fetal sheep.

Jonker SS, Giraud GD, Chang EI, Elman MR, Louey S

FASEB journal : official publication of the Federation of American Societies for Experimental Biology23 Jun 2020Cited by 10 (Europe PMC)

PMID32573852 (opens in a new tab)PMCIDPMC7688557 (opens in a new tab)DOI10.1096/fj.202000215r (opens in a new tab)PepBankPUB-32573852
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Mechanism

    In near-term fetal sheep, coronary conductance was preserved on a per-gram basis after IGF‑1 LR3 treatment.

    In plain wordsIn fetal sheep, heart blood vessels kept normal conductance per gram of heart after IGF‑1 LR3 treatment.

    Peptide
    IGF-1 LR3
    Outcome
    No significant changeCoronary conductance per gram
    Study

    sheepn: not reported in source

    Near-term fetal sheep
    Comparator
    Vehicle
    Outcome group
    Heart function · Cardiovascular
    Studied dose
    Dose not stated · 127 to 134 d gestationAs given in this study (sheep).

    Source sentences

    Summary
    coronary conductance was preserved on a per-gram basis following IGF-1 treatment
    1 context sentence
    Summary · context
    Near-term fetal sheep underwent surgical instrumentation and were studied from 127 to 134 d gestation (term = 147 d), receiving either IGF-1 LR3 or vehicle.
  2. 02AnimalAnimal study (in vivo)Mechanism

    In near-term fetal sheep, adenosine contributed to hypoxia-mediated coronary vasodilation similarly in IGF‑1 LR3-treated and control fetuses.

    In plain wordsIn fetal sheep, adenosine played a similar role in widening heart vessels during low oxygen with or without IGF‑1 LR3.

    Peptide
    IGF-1 LR3
    Outcome
    No significant changeAdenosine contribution to hypoxia-mediated coronary vasodilation
    Study

    sheepn: not reported in source

    Near-term fetal sheep
    Comparator
    Vehicle
    Outcome group
    Heart function · Cardiovascular
    Studied dose
    Dose not stated · 127 to 134 d gestationAs given in this study (sheep).

    Source sentences

    Summary
    adenosine and nitric oxide contributed to hypoxia-mediated coronary vasodilation similarly in IGF-1-treated and Control fetuses
    1 context sentence
    Summary · context
    Near-term fetal sheep underwent surgical instrumentation and were studied from 127 to 134 d gestation (term = 147 d), receiving either IGF-1 LR3 or vehicle.
  3. 03AnimalAnimal study (in vivo)Mechanism

    In near-term fetal sheep, nitric oxide contributed to hypoxia-mediated coronary vasodilation similarly in IGF‑1 LR3-treated and control fetuses.

    In plain wordsIn fetal sheep, nitric oxide played a similar role in widening heart vessels during low oxygen with or without IGF‑1 LR3.

    Peptide
    IGF-1 LR3
    Outcome
    No significant changeNitric oxide contribution to hypoxia-mediated coronary vasodilation
    Study

    sheepn: not reported in source

    Near-term fetal sheep
    Comparator
    Vehicle
    Outcome group
    Heart function · Cardiovascular
    Studied dose
    Dose not stated · 127 to 134 d gestationAs given in this study (sheep).

    Source sentences

    Summary
    adenosine and nitric oxide contributed to hypoxia-mediated coronary vasodilation similarly in IGF-1-treated and Control fetuses
    1 context sentence
    Summary · context
    Near-term fetal sheep underwent surgical instrumentation and were studied from 127 to 134 d gestation (term = 147 d), receiving either IGF-1 LR3 or vehicle.
  4. 04AnimalAnimal study (in vivo)Mechanism

    In near-term fetal sheep, the relationships between coronary flow and blood oxygen contents were similar between IGF‑1 LR3 and vehicle groups.

    In plain wordsIn fetal sheep, the link between heart blood flow and blood oxygen was similar with IGF‑1 LR3 and vehicle.

    Peptide
    IGF-1 LR3
    Outcome
    No significant changeRelationship between coronary flow and blood oxygen content
    Study

    sheepn: not reported in source

    Near-term fetal sheep
    Comparator
    Vehicle
    Outcome group
    Heart function · Cardiovascular
    Studied dose
    Dose not stated · 127 to 134 d gestationAs given in this study (sheep).

    Source sentences

    Summary
    the relationships between coronary flow and blood oxygen contents were similar between groups
    1 context sentence
    Summary · context
    Near-term fetal sheep underwent surgical instrumentation and were studied from 127 to 134 d gestation (term = 147 d), receiving either IGF-1 LR3 or vehicle.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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