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Study · Animal study (in vivo) · horse · 2020

4 results

Effect of Chronic Administration of Oxytocin on Corpus Luteum Function in Cycling Mares.

Parkinson KC, Vanderwall DK, Rigas J, Sweat A

Journal of equine veterinary science16 Mar 2020Cited by 1 (Europe PMC)

PMID32534769 (opens in a new tab)DOI10.1016/j.jevs.2020.102991 (opens in a new tab)PepBankPUB-32534769
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In cycling mares, daily intramuscular oxytocin for 29 days gave a higher proportion with prolonged corpus luteum function than saline (7 of 9 versus 1 of 7).

    In plain wordsIn mares, daily oxytocin injections kept the corpus luteum working for longer in more animals than saline did.

    Peptide
    Oxytocin
    Outcome
    IncreaseProportion of mares with prolonged corpus luteum function
    Study

    horsen = 16

    Cycling mares
    Comparator
    Saline
    Analysis
    Primary
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    60 units once daily · intramuscular · 29 daysAs given in this study (horse).

    Source sentences

    Summary
    The proportion of mares with prolonged CL function was higher in the oxytocin-treated group than in the saline-treated group (7/9 vs. 1/7, respectively; P < .05).
    2 context sentences
    Summary · context
    Mares were randomly assigned to two groups: (1) saline-treated control (n = 7) and (2) oxytocin-treated (n = 9) subjects.
    Summary · context
    Control mares received 3 cc of saline, and oxytocin-treated mares received 60 units (3 cc) of oxytocin intramuscularly for 29 consecutive days.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In 3 of the 7 oxytocin-treated mares with prolonged corpus luteum function, luteolysis occurred within 4-7 days of starting treatment, and prolonged function followed after the next ovulation.

    In plain wordsIn some oxytocin-treated mares, the corpus luteum first regressed within days and prolonged function developed after the next ovulation.

    Peptide
    Oxytocin
    Outcome
    Not applicableInitial luteolysis followed by prolonged corpus luteum function
    Study

    horsen = 7

    Cycling mares
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    60 units once daily · intramuscular · 29 daysAs given in this study (horse).

    Source sentences

    Summary
    Three of the seven oxytocin-treated mares that developed prolonged CL function initially underwent luteolysis within 4-7 days of the start of oxytocin treatment and then developed prolonged CL function after the subsequent ovulation during the treatment period.
    2 context sentences
    Summary · context
    Mares were randomly assigned to two groups: (1) saline-treated control (n = 7) and (2) oxytocin-treated (n = 9) subjects.
    Summary · context
    Control mares received 3 cc of saline, and oxytocin-treated mares received 60 units (3 cc) of oxytocin intramuscularly for 29 consecutive days.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In 4 oxytocin-treated mares with prolonged corpus luteum function, progesterone stayed above 1.0 ng/mL throughout treatment and into the post-treatment period.

    In plain wordsIn four oxytocin-treated mares, progesterone stayed high during and after the treatment period.

    Peptide
    Oxytocin
    Outcome
    Not applicableProgesterone above 1.0 ng/mL throughout treatment and after
    Study

    horsen = 4

    Cycling mares
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    60 units once daily · intramuscular · 29 daysAs given in this study (horse).

    Source sentences

    Summary
    In the other four oxytocin-treated mares that developed prolonged CL function, progesterone remained >1.0 ng/mL throughout the treatment period and into the post-treatment period.
    2 context sentences
    Summary · context
    Mares were randomly assigned to two groups: (1) saline-treated control (n = 7) and (2) oxytocin-treated (n = 9) subjects.
    Summary · context
    Control mares received 3 cc of saline, and oxytocin-treated mares received 60 units (3 cc) of oxytocin intramuscularly for 29 consecutive days.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In mares with prolonged corpus luteum function (the study reports this group without separating the treatment arms), progesterone stayed elevated through at least day 55.

    In plain wordsIn mares whose corpus luteum kept working, progesterone stayed high until at least day 55; the result is not split by treatment group.

    Peptide
    Oxytocin
    Outcome
    Not applicableDuration of elevated progesterone in mares with prolonged corpus luteum function
    Study

    horsen: not reported in source

    Cycling mares
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    60 units once daily · intramuscular · 29 daysAs given in this study (horse).

    Source sentences

    Summary
    All mares with prolonged CL function maintained elevated progesterone concentrations through at least day 55 of the study.
    2 context sentences
    Summary · context
    Mares were randomly assigned to two groups: (1) saline-treated control (n = 7) and (2) oxytocin-treated (n = 9) subjects.
    Summary · context
    Control mares received 3 cc of saline, and oxytocin-treated mares received 60 units (3 cc) of oxytocin intramuscularly for 29 consecutive days.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 00:50 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:48 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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