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Study · Randomized controlled trial · 2020

2 results

A registered replication study on oxytocin and trust.

Declerck CH, Boone C, Pauwels L, Vogt B, Fehr E

Nature human behaviour8 Jun 2020Cited by 96 (Europe PMC)

PMID32514040 (opens in a new tab)DOI10.1038/s41562-020-0878-x (opens in a new tab)PepBankPUB-32514040
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

2 results from studies that gave the peptide. 2 results from people.

  1. 01HumanRandomized controlled trialEfficacy outcome

    In exploratory post hoc analyses of a trust game replication, oxytocin may have increased trust in individuals with a low disposition to trust in the no-social-contact condition.

    In plain wordsIn exploratory analyses, oxytocin may have raised trust in people with a low tendency to trust, but this needs confirmation.

    Peptide
    Oxytocin
    Outcome
    IncreaseTrusting behaviour in individuals with low disposition to trust (no-social-contact condition)
    Study

    n: not reported in source

    Comparator
    Placebo
    Analysis
    Exploratory
    Outcome group
    Cognition and memory · Mental health and mood
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Exploratory post hoc analyses suggest that OT may increase trust in individuals with a low disposition to trust in the NoC condition
    1 context sentence
    Summary · context
    Here, we performed a large double-blind and placebo-controlled replication study of the effects of OT on trusting behaviour that yields a power of more than 95% and implements an MSC condition as well as a no-social-contact (NoC) condition.
  2. 02HumanRandomized controlled trialEfficacy outcome

    In a registered replication of the trust game, oxytocin had no effect on trusting behaviour in the minimal social contact condition.

    In plain wordsIn a large replication study, oxytocin did not change trusting behaviour compared with placebo when minimal social contact was present.

    Peptide
    Oxytocin
    Outcome
    No significant changeTrusting behaviour in the trust game (minimal social contact condition)
    Study

    n: not reported in source

    Comparator
    Placebo
    Outcome group
    Cognition and memory · Mental health and mood
    Studied dose
    Dose not stated

    Source sentences

    Summary
    We find no effect of OT on trusting behaviour in the MSC condition.
    1 context sentence
    Summary · context
    Here, we performed a large double-blind and placebo-controlled replication study of the effects of OT on trusting behaviour that yields a power of more than 95% and implements an MSC condition as well as a no-social-contact (NoC) condition.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 00:50 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:49 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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