Mechano growth factor interacts with nucleolin to protect against cisplatin-induced neurotoxicity.

Podratz JL, Tang JJ, Polzin MJ, Schmeichel AM, Nesbitt JJ, Windebank AJ, Madigan NN

Experimental neurology5 Jun 2020Cited by 4 (Europe PMC)

PMID32511954DOI10.1016/j.expneurol.2020.113376PepBankPUB-32511954

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study7

3 results from studies that gave the peptide. No result from this study comes from people.

01LabIn vitro (cells)Efficacy outcome
In vitro, exogenous MGF protected embryonic dorsal root ganglion neurons from cisplatin-induced cell death.
In plain wordsIn nerve cells in a dish, added MGF protected embryonic sensory neurons from cisplatin-induced cell death.
Peptide
MGF / PEG-MGF
Outcome
IncreaseEmbryonic DRG neuron survival with exogenous MGF
Study
n: not reported in source
Embryonic DRG neurons, cisplatin-induced cell death
Outcome group
Neuroprotection · Nervous system and cognition
Studied dose
Dose not stated
Source sentences
Summary
Exogenous MGF and MGF with a cysteine added to the N-terminus (CMGF) also protected embryonic DRG neurons from cisplatin-induced cell death in vitro.
1 context sentence(design, population, supporting numbers)
Summary · context
Our studies were designed to see if MGF would protect dorsal root ganglion (DRG) neurons from cisplatin-induced neurotoxicity and to identify potential mechanisms that may be involved.
Report a problemFND-3251195402
02LabIn vitro (cells)Mechanism
Mass spectroscopy of proteins bound to MGF showed that nucleolin is a key binding partner.
In plain wordsIn lab tests, the protein nucleolin was a key binding partner of MGF.
Peptide
MGF / PEG-MGF
Outcome
Not applicableNucleolin as MGF binding partner
Study
n: not reported in source
Mass spectroscopy of proteins bound to MGF
Outcome group
Receptor activity and mechanism · Nervous system and cognition
Studied dose
Dose not stated
Source sentences
Summary
Mass spectroscopy analysis of proteins bound to MGF showed that nucleolin is a key-binding partner.
Report a problemFND-3251195404
03LabIn vitro (cells)Mechanism
In culture, antibodies against nucleolin prevented the neuroprotective effect of MGF and CMGF.
In plain wordsIn nerve cells in a dish, blocking nucleolin removed the protective effect of MGF and CMGF.
Peptide
MGF / PEG-MGF
Outcome
Not applicableNucleolin antibodies and MGF neuroprotection
Study
n: not reported in source
Cultured DRG neurons with cisplatin
Comparator
MGF and CMGF without nucleolin antibodies
Outcome group
Neuroprotection · Nervous system and cognition
Studied dose
Dose not stated
Source sentences
Summary
Antibodies against nucleolin prevented the neuroprotective effect of MGF and CMGF in culture.
Report a problemFND-3251195405

Natural levels measured1

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

04LabEndogenous levelIn vitro (cells)Mechanism
Both nucleolin and MGF are located in the nucleolus of dorsal root ganglion neurons.
In plain wordsIn sensory nerve cells, the body's own MGF and nucleolin sit in the same part of the nucleus.
Peptide
MGF / PEG-MGF
Outcome
Not applicableSubcellular location of MGF and nucleolin
Study
n: not reported in source
DRG neurons
Outcome group
Receptor activity and mechanism · Nervous system and cognition
Source sentences
Summary
Both nucleolin and MGF are located in the nucleolus of DRG neurons.
This result measures the body's own MGF / PEG-MGF. Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-3251195406

Studies that did not test the peptide alone3

In this study, MGF / PEG-MGF was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking MGF / PEG-MGF.

05AnimalNot a test of MGF / PEG-MGF aloneAnimal study (in vivo)Efficacy outcome
In vivo, expression of endogenous MGF in adult dorsal root ganglion neurons ameliorated cisplatin-induced thermal hyperalgesia.
In plain wordsIn animals, MGF expressed in sensory nerve cells reduced heat pain sensitivity caused by cisplatin.
Peptide
MGF / PEG-MGF
Outcome
DecreaseCisplatin-induced thermal hyperalgesia with MGF expression in DRG neurons
Study
n: not reported in source
Adult DRG neurons in vivo expressing MGF
Outcome group
Pain · Nervous system and cognition
Source sentences
Summary
Expression of endogenous MGF in adult DRG neurons in vivo ameliorated cisplatin-induced thermal hyperalgesia.
1 context sentence(design, population, supporting numbers)
Summary · context
Our studies were designed to see if MGF would protect dorsal root ganglion (DRG) neurons from cisplatin-induced neurotoxicity and to identify potential mechanisms that may be involved.
In this study, MGF / PEG-MGF was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking MGF / PEG-MGF.
Report a problemFND-3251195401
06LabNot a test of MGF / PEG-MGF aloneIn vitro (cells)Efficacy outcome
In vitro, MGF with a cysteine added to the N-terminus (CMGF) protected embryonic dorsal root ganglion neurons from cisplatin-induced cell death.
In plain wordsIn nerve cells in a dish, a modified MGF with an added cysteine protected embryonic sensory neurons from cisplatin-induced cell death.
Peptide
MGF / PEG-MGF
Outcome
IncreaseEmbryonic DRG neuron survival with CMGF
Study
n: not reported in source
Embryonic DRG neurons, cisplatin-induced cell death
Outcome group
Neuroprotection · Nervous system and cognition
Source sentences
Summary
Exogenous MGF and MGF with a cysteine added to the N-terminus (CMGF) also protected embryonic DRG neurons from cisplatin-induced cell death in vitro.
1 context sentence(design, population, supporting numbers)
Summary · context
Our studies were designed to see if MGF would protect dorsal root ganglion (DRG) neurons from cisplatin-induced neurotoxicity and to identify potential mechanisms that may be involved.
In this study, MGF / PEG-MGF was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking MGF / PEG-MGF.
Report a problemFND-3251195403
07LabNot a test of MGF / PEG-MGF aloneIn vitro (cells)Mechanism
RNAseq of RNA associated with MGF indicated that MGF may be involved in RNA processing, protein targeting and transcription/translation.
In plain wordsIn lab tests, RNA linked to MGF suggested MGF may be involved in RNA processing and protein production.
Peptide
MGF / PEG-MGF
Outcome
Not applicableRNA associated with MGF
Study
n: not reported in source
RNAseq of RNA associated with MGF
Outcome group
Receptor activity and mechanism · Nervous system and cognition
Source sentences
Summary
RNAseq of RNA associated with MGF indicated that MGF may be involved in RNA processing, protein targeting and transcription/translation.
In this study, MGF / PEG-MGF was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking MGF / PEG-MGF.
Report a problemFND-3251195407

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
13 Oct 2026, 21:44 UTC
Study results updated
Version 1
13 Oct 2026, 16:31 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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