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Study · Randomized controlled trial · n = 100 · 2020

2 results

Salivary oxytocin after oxytocin administration: Examining the moderating role of childhood trauma.

Fragkaki I, Glennon JC, Cima M

Biological psychology20 May 2020Cited by 5 (Europe PMC)

PMID32442673 (opens in a new tab)DOI10.1016/j.biopsycho.2020.107903 (opens in a new tab)PepBankPUB-32442673
Publisher pagePubMedAsk about this study
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Summary

Although oxytocin administration influences behavior, its effects on peripheral oxytocin concentrations are mixed and derived from studies on healthy subjects. Additionally, trauma attenuates the behavioral effects of oxytocin, but it is unknown whether it also influences its effect on peripheral circulation. This study examined whether salivary oxytocin increased after oxytocin administration and whether trauma attenuated this effect. We conducted a randomized, double-blind, placebo-controlled, within-subjects study in 100 male adolescents living in residential youth care facilities. Participants self-administered intranasally 24 IU of oxytocin and placebo (one week later) and provided a saliva sample before and 15 min after administration. Salivary oxytocin increased significantly after oxytocin administration, but this effect might be inflated by exogenous oxytocin reaching the throat. Trauma did not moderate this effect. Our findings suggest that trauma did not attenuate the effect of oxytocin administration on salivary oxytocin, but more robust methodologies are recommended to draw more solid conclusions.
CC BYText from Europe PMC. Highlighted sentences are the source of results.

Results from this study2

2 results from studies that gave the peptide. 2 results from people.

  1. 01HumanRandomized controlled trialPharmacokinetics

    In male adolescents in residential youth care, salivary oxytocin increased after intranasal oxytocin, possibly inflated by exogenous oxytocin reaching the throat.

    In plain wordsIn male adolescents in youth care, salivary oxytocin rose after nasal oxytocin, but the rise may partly come from the spray reaching the throat.

    Peptide
    Oxytocin
    Outcome
    IncreaseSalivary oxytocin concentration after administration
    Study

    n = 100

    Comparator
    Placebo
    Outcome group
    Pharmacokinetics · Pharmacology
    Studied dose
    24 IU · intranasalAs given in this study (human).

    Source sentences

    Summary
    Salivary oxytocin increased significantly after oxytocin administration, but this effect might be inflated by exogenous oxytocin reaching the throat.
    2 context sentences
    Summary · context
    We conducted a randomized, double-blind, placebo-controlled, within-subjects study in 100 male adolescents living in residential youth care facilities.
    Summary · context
    Participants self-administered intranasally 24 IU of oxytocin and placebo (one week later) and provided a saliva sample before and 15 min after administration.
  2. 02HumanRandomized controlled trialMechanism

    In male adolescents in residential youth care, childhood trauma did not moderate the rise in salivary oxytocin after intranasal oxytocin.

    In plain wordsIn male adolescents in youth care, childhood trauma did not change how much salivary oxytocin rose after nasal oxytocin.

    Peptide
    Oxytocin
    Outcome
    No significant changeModeration of salivary oxytocin increase by childhood trauma
    Study

    n = 100

    Comparator
    Placebo
    Outcome group
    Pharmacokinetics · Pharmacology
    Studied dose
    24 IU · intranasalAs given in this study (human).

    Source sentences

    Summary
    Trauma did not moderate this effect.
    2 context sentences
    Summary · context
    We conducted a randomized, double-blind, placebo-controlled, within-subjects study in 100 male adolescents living in residential youth care facilities.
    Summary · context
    Participants self-administered intranasally 24 IU of oxytocin and placebo (one week later) and provided a saliva sample before and 15 min after administration.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 00:50 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:48 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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