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Study · In vitro (cells) · 2020

4 results

Gene expression in human mesenchymal stem cell aging cultures: modulation by short peptides.

Ashapkin V, Khavinson V, Shilovsky G, Linkova N, Vanuyshin B

Molecular biology reports12 May 2020Cited by 10 (Europe PMC)

PMID32399807 (opens in a new tab)DOI10.1007/s11033-020-05506-3 (opens in a new tab)PepBankPUB-32399807
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Mechanism

    In aging human mesenchymal stem cells, KED inhibited FOXO1 expression by 1.6-2.3 fold.

    In plain wordsIn cells, KED reduced FOXO1 expression by 1.6-2.3 fold.

    Peptide
    Vesugen (KED)
    Outcome
    DecreaseFOXO1 gene expression
    Study

    humann: not reported in source

    FetMSCs in passages or stationary aging cultures
    Outcome group
    Aging markers · Aging and longevity
    Studied dose
    Dose not stated

    Measurements

    FOXO1 expression inhibition
    1.6 to 2.3 fold
    KED

    Source sentences

    Summary
    KED peptide inhibited FOXO1 gene expression by 1.6-2.3 fold.
    1 context sentence
    Summary · context
    Effects of the short peptides Ala-Glu-Asp (AED), Lys-Glu-Asp (KED) and Lys-Glu (KE) on the expression of IGF1, FOXO1, TERT, TNKS2, and NFκB genes were studied in human embryo bone marrow mesenchymal stem cells (line FetMSCs) variously aged in "passages" or "stationary" cultures.
  2. 02LabIn vitro (cells)Mechanism

    In human mesenchymal stem cells, KED inhibited TNKS2 expression in the passages aging model.

    In plain wordsIn cells, KED reduced TNKS2 expression in the passages aging model.

    Peptide
    Vesugen (KED)
    Outcome
    DecreaseTNKS2 expression in passages aging
    Study

    humann: not reported in source

    FetMSCs in passages or stationary aging cultures
    Outcome group
    Aging markers · Aging and longevity
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The most striking difference in the peptide effect on cell aging between "passages" and "stationary" aging models was in the KED effects on TNKS2 gene expression; this expression was inhibited by KED in the "passages" model, while stimulation was observed in the "stationary" model.
    1 context sentence
    Summary · context
    Effects of the short peptides Ala-Glu-Asp (AED), Lys-Glu-Asp (KED) and Lys-Glu (KE) on the expression of IGF1, FOXO1, TERT, TNKS2, and NFκB genes were studied in human embryo bone marrow mesenchymal stem cells (line FetMSCs) variously aged in "passages" or "stationary" cultures.
  3. 03LabIn vitro (cells)Mechanism

    In human mesenchymal stem cells, KED stimulated TNKS2 expression in the stationary aging model.

    In plain wordsIn cells, KED increased TNKS2 expression in the stationary aging model.

    Peptide
    Vesugen (KED)
    Outcome
    IncreaseTNKS2 expression in stationary aging
    Study

    humann: not reported in source

    FetMSCs in passages or stationary aging cultures
    Outcome group
    Aging markers · Aging and longevity
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The most striking difference in the peptide effect on cell aging between "passages" and "stationary" aging models was in the KED effects on TNKS2 gene expression; this expression was inhibited by KED in the "passages" model, while stimulation was observed in the "stationary" model.
    1 context sentence
    Summary · context
    Effects of the short peptides Ala-Glu-Asp (AED), Lys-Glu-Asp (KED) and Lys-Glu (KE) on the expression of IGF1, FOXO1, TERT, TNKS2, and NFκB genes were studied in human embryo bone marrow mesenchymal stem cells (line FetMSCs) variously aged in "passages" or "stationary" cultures.
  4. 04LabIn vitro (cells)Mechanism

    In human mesenchymal stem cells, KED stimulated NFκB expression in both aging models.

    In plain wordsIn cells, KED increased NFκB expression in both aging models.

    Peptide
    Vesugen (KED)
    Outcome
    IncreaseNFκB gene expression
    Study

    humann: not reported in source

    FetMSCs in passages or stationary aging cultures
    Outcome group
    Aging markers · Aging and longevity
    Studied dose
    Dose not stated

    Source sentences

    Summary
    AED, KED, and KE stimulated expression of the NFκB gene in both models.
    1 context sentence
    Summary · context
    Effects of the short peptides Ala-Glu-Asp (AED), Lys-Glu-Asp (KED) and Lys-Glu (KE) on the expression of IGF1, FOXO1, TERT, TNKS2, and NFκB genes were studied in human embryo bone marrow mesenchymal stem cells (line FetMSCs) variously aged in "passages" or "stationary" cultures.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    21 Oct 2026, 17:05 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 16:35 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

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