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Study · Randomized controlled trial · n = 112 · 2020

3 results

The effect of oxytocin, gender, and ovarian hormones on stress reactivity in individuals with cocaine use disorder.

Sherman BJ, Baker NL, Brady KT, Joseph JE, Nunn LM, McRae-Clark A

Psychopharmacology9 May 2020Cited by 15 (Europe PMC)

PMID32388622 (opens in a new tab)PMCIDPMC8210538 (opens in a new tab)DOI10.1007/s00213-020-05516-w (opens in a new tab)PepBankPUB-32388622
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. 3 results from people.

  1. 01HumanRandomized controlled trialEfficacy outcome

    In adults with cocaine use disorder, oxytocin had no significant effect on craving, and gender did not moderate this.

    In plain wordsIn adults with cocaine use disorder, oxytocin did not change craving compared with placebo.

    Peptide
    Oxytocin
    Outcome
    No significant changeCraving response to social stressor
    Study

    n = 112

    Comparator
    Placebo
    Outcome group
    Anxiety and mood · Mental health and mood
    Studied dose
    40 IU · intranasalAs given in this study (human).

    Source sentences

    Summary
    Oxytocin had no significant effect on craving or stress
    2 context sentences
    Summary · context
    and gender did not moderate the effect of oxytocin on either measure.
    Summary · context
    One hundred twelve adults with CUD were randomized to receive 40 IU intranasal oxytocin (n = 56) or matching placebo (n = 56). Forty minutes after drug administration, participants were exposed to a social stressor.
  2. 02HumanRandomized controlled trialEfficacy outcome

    In adults with cocaine use disorder, oxytocin had no significant effect on subjective stress, and gender did not moderate this.

    In plain wordsIn adults with cocaine use disorder, oxytocin did not change reported stress compared with placebo.

    Peptide
    Oxytocin
    Outcome
    No significant changeSubjective stress response to social stressor
    Study

    n = 112

    Comparator
    Placebo
    Outcome group
    Anxiety and mood · Mental health and mood
    Studied dose
    40 IU · intranasalAs given in this study (human).

    Source sentences

    Summary
    Oxytocin had no significant effect on craving or stress, and gender did not moderate the effect of oxytocin on either measure.
    1 context sentence
    Summary · context
    One hundred twelve adults with CUD were randomized to receive 40 IU intranasal oxytocin (n = 56) or matching placebo (n = 56). Forty minutes after drug administration, participants were exposed to a social stressor.
  3. 03HumanRandomized controlled trialEfficacy outcome

    In adults with cocaine use disorder, women receiving intranasal oxytocin showed a blunted cortisol response to a social stressor compared with the other three groups; gender moderated the effect (p = 0.048).

    In plain wordsIn adults with cocaine use disorder, women given oxytocin had a smaller stress hormone rise than women on placebo and men in both groups.

    Peptide
    Oxytocin
    Outcome
    DecreaseCortisol response to social stressor in women
    Study

    n: not reported in source

    Comparator
    Placebo
    Outcome group
    Anxiety and mood · Endocrine and hormones
    Studied dose
    40 IU · intranasalAs given in this study (human).

    Source sentences

    Summary
    Gender moderated the effect of oxytocin on neuroendocrine response (p = 0.048); women receiving oxytocin (F + OXY) showed blunted cortisol response compared to the other three groups (F + PBO; M + OXY; M + PBO).
    1 context sentence
    Summary · context
    One hundred twelve adults with CUD were randomized to receive 40 IU intranasal oxytocin (n = 56) or matching placebo (n = 56). Forty minutes after drug administration, participants were exposed to a social stressor.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 00:50 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:48 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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