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Study · Animal study (in vivo) · rabbit · 2020

5 results

MGF-19E peptide promoted proliferation, differentiation and mineralization of MC3T3-E1 cell and promoted bone defect healing.

Wei W, Liu S, Song J, Feng T, Yang R, Cheng Y, Li H, Hao L

Gene24 Apr 2020Cited by 8 (Europe PMC)

PMID32339623 (opens in a new tab)DOI10.1016/j.gene.2020.144703 (opens in a new tab)PepBankPUB-32339623
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

5 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In a rabbit bone defect model, low-dose T-MGF-19E peptide significantly promoted bone injury healing.

    In plain wordsIn rabbits with a bone defect, a low dose of T-MGF-19E peptide promoted bone healing.

    Peptide
    MGF / PEG-MGF
    Outcome
    IncreaseBone injury healing with low-dose T-MGF-19E
    Study

    rabbitn: not reported in source

    Rabbit bone defect model
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    low doseAs given in this study (rabbit).

    Source sentences

    Summary
    The rabbit bone defect model showed that the low-dose T-MGF-19E peptide significantly promoted bone injury healing, suggesting its promoting effect on the healing of bone injury.
    1 context sentence
    Summary · context
    A rabbit bone injury model was constructed, and the repair function of MGF E peptide was verified by injecting the candidate MGF E peptide.
  2. 02LabIn vitro (cells)Efficacy outcome

    T-MGF-19E peptide obviously promoted MC3T3-E1 cell proliferation by regulating the cell cycle at 72 h.

    In plain wordsIn bone-forming cells, the T-MGF-19E peptide promoted cell growth by changing the cell cycle.

    Peptide
    MGF / PEG-MGF
    Outcome
    IncreaseMC3T3-E1 cell proliferation with T-MGF-19E
    Study

    n: not reported in source

    MC3T3-E1 cells
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    Dose not stated · 72 hAs given in this study.

    Source sentences

    Summary
    T-MGF-19E peptide obviously promoted cell proliferation by regulating cell cycle after MGF E peptide treatment at 72 h.
    1 context sentence
    Summary · context
    In this study, we classified different lengths of mechano growth factor (MGF) E peptides in different species and analyzed their effects on MC3T3-E1 cell proliferation, cell cycle, alkaline phosphatase (ALP) activity, differentiation-related factor expression, and cell mineralization.
  3. 03LabIn vitro (cells)Efficacy outcome

    T-MGF-25E and T-MGF-19E peptides significantly promoted osteoblast differentiation on day 14.

    In plain wordsIn bone-forming cells, the T-MGF-25E and T-MGF-19E peptides promoted cell maturation by day 14.

    Peptide
    MGF / PEG-MGF
    Outcome
    IncreaseOsteoblast differentiation at day 14 with T-MGF-25E and T-MGF-19E
    Study

    n: not reported in source

    MC3T3-E1 cells
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    Dose not stated · 14 daysAs given in this study.

    Source sentences

    Summary
    T-MGF-25E and T-MGF-19E peptide significantly promoted the differentiation of osteoblasts on day 14
    1 context sentence
    Summary · context
    In this study, we classified different lengths of mechano growth factor (MGF) E peptides in different species and analyzed their effects on MC3T3-E1 cell proliferation, cell cycle, alkaline phosphatase (ALP) activity, differentiation-related factor expression, and cell mineralization.
  4. 04LabIn vitro (cells)Efficacy outcome

    M-MGF-25E peptide promoted osteoblast differentiation on day 7.

    In plain wordsIn bone-forming cells, the M-MGF-25E peptide promoted cell maturation by day 7.

    Peptide
    MGF / PEG-MGF
    Outcome
    IncreaseOsteoblast differentiation at day 7 with M-MGF-25E
    Study

    n: not reported in source

    MC3T3-E1 cells
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    Dose not stated · 7 daysAs given in this study.

    Source sentences

    Summary
    M-MGF-25E peptide promoted cell differentiation on day 7.
    1 context sentence
    Summary · context
    In this study, we classified different lengths of mechano growth factor (MGF) E peptides in different species and analyzed their effects on MC3T3-E1 cell proliferation, cell cycle, alkaline phosphatase (ALP) activity, differentiation-related factor expression, and cell mineralization.
  5. 05LabIn vitro (cells)Efficacy outcome

    T-MGF-19E, T-MGF-25E and M-MGF-19E peptides significantly promoted osteoblast mineralization, with T-MGF-19E showing the most significant effect.

    In plain wordsIn bone-forming cells, three MGF E peptides promoted mineral deposits, and T-MGF-19E had the strongest effect.

    Peptide
    MGF / PEG-MGF
    Outcome
    IncreaseOsteoblast mineralization with T-MGF-19E, T-MGF-25E and M-MGF-19E
    Study

    n: not reported in source

    MC3T3-E1 cells
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    T-MGF-19E, T-MGF-25E, and M-MGF-19E significantly promoted osteoblast mineralization, with T-MGF19E showing the most significant effect.
    1 context sentence
    Summary · context
    In this study, we classified different lengths of mechano growth factor (MGF) E peptides in different species and analyzed their effects on MC3T3-E1 cell proliferation, cell cycle, alkaline phosphatase (ALP) activity, differentiation-related factor expression, and cell mineralization.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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