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Study · Animal study (in vivo) · rabbit · 2020

4 results

Selepressin, a novel selective V1A receptor agonist: Effect on mesenteric flow and gastric mucosa perfusion in the endotoxemic rabbit.

Milano SP, Boucheix OB, Reinheimer TM

Peptides22 Apr 2020Cited by 4 (Europe PMC)

PMID32330539 (opens in a new tab)DOI10.1016/j.peptides.2020.170318 (opens in a new tab)PepBankPUB-32330539
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: CC BY-NC-ND. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Safety outcome

    In endotoxemic rabbits, selepressin reduced mesenteric blood flow significantly less than arginine vasopressin.

    In plain wordsIn endotoxemic rabbits, selepressin reduced intestinal blood flow significantly less than arginine vasopressin.

    Peptide
    Selepressin
    Outcome
    IncreaseMesenteric blood flow
    Study

    rabbitn: not reported in source

    Lipopolysaccharide-induced endotoxemia and non-endotoxemic controls
    Comparator
    Arginine vasopressin
    Outcome group
    Vascular function · Gastrointestinal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    AVP induced a pronounced decrease in MBF and GMP in non-endotoxemic and endotoxemic rabbits, whereas the reduction after selepressin treatment was significantly less for both indicators in the endotoxemic animals.
    1 context sentence
    Summary · context
    Selepressin, non-selective AVP, and NE effects on mesenteric blood flow (MBF) and gastric mucosa perfusion (GMP) were compared in control rabbits and a lipopolysaccharide-induced, fluid-resuscitated rabbit endotoxemia model.
  2. 02AnimalAnimal study (in vivo)Safety outcome

    In endotoxemic rabbits, selepressin reduced gastric mucosa perfusion significantly less than arginine vasopressin.

    In plain wordsIn endotoxemic rabbits, selepressin reduced blood supply to the stomach lining significantly less than arginine vasopressin.

    Peptide
    Selepressin
    Outcome
    IncreaseGastric mucosa perfusion
    Study

    rabbitn: not reported in source

    Lipopolysaccharide-induced endotoxemia and non-endotoxemic controls
    Comparator
    Arginine vasopressin
    Outcome group
    Vascular function · Gastrointestinal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    AVP induced a pronounced decrease in MBF and GMP in non-endotoxemic and endotoxemic rabbits, whereas the reduction after selepressin treatment was significantly less for both indicators in the endotoxemic animals.
    1 context sentence
    Summary · context
    Selepressin, non-selective AVP, and NE effects on mesenteric blood flow (MBF) and gastric mucosa perfusion (GMP) were compared in control rabbits and a lipopolysaccharide-induced, fluid-resuscitated rabbit endotoxemia model.
  3. 03AnimalAnimal study (in vivo)Safety outcome

    In non-endotoxemic and endotoxemic rabbits, selepressin induced a pronounced dose-dependent increase in mesenteric vascular resistance.

    In plain wordsIn rabbits with and without endotoxemia, selepressin increased intestinal blood vessel resistance in a dose-dependent manner.

    Peptide
    Selepressin
    Outcome
    IncreaseMesenteric vascular resistance
    Study

    rabbitn: not reported in source

    Lipopolysaccharide-induced endotoxemia and non-endotoxemic controls
    Outcome group
    Vascular function · Gastrointestinal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Selepressin and AVP induced a pronounced dose-dependent increase in mesenteric vascular resistance in non-endotoxemic and endotoxemic rabbits, tending to be less in endotoxemic animals, whereas a minor increase in both groups was observed with NE.
    1 context sentence
    Summary · context
    Selepressin, non-selective AVP, and NE effects on mesenteric blood flow (MBF) and gastric mucosa perfusion (GMP) were compared in control rabbits and a lipopolysaccharide-induced, fluid-resuscitated rabbit endotoxemia model.
  4. 04AnimalAnimal study (in vivo)Safety outcome

    In rabbits, selepressin-induced mesenteric vascular resistance increases tended to be smaller with endotoxemia than without endotoxemia.

    In plain wordsIn rabbits, selepressin tended to increase intestinal blood vessel resistance less with endotoxemia than without it.

    Peptide
    Selepressin
    Outcome
    DecreaseMesenteric vascular resistance by endotoxemia status
    Study

    rabbitn: not reported in source

    Lipopolysaccharide-induced endotoxemia and non-endotoxemic controls
    Comparator
    Non-endotoxemic rabbits
    Outcome group
    Vascular function · Gastrointestinal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Selepressin and AVP induced a pronounced dose-dependent increase in mesenteric vascular resistance in non-endotoxemic and endotoxemic rabbits, tending to be less in endotoxemic animals, whereas a minor increase in both groups was observed with NE.
    1 context sentence
    Summary · context
    Selepressin, non-selective AVP, and NE effects on mesenteric blood flow (MBF) and gastric mucosa perfusion (GMP) were compared in control rabbits and a lipopolysaccharide-induced, fluid-resuscitated rabbit endotoxemia model.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    27 Oct 2026, 18:20 UTC

    Study results updated

  2. Version 1

    27 Oct 2026, 16:32 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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