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Study · Measured the body's own peptide · 2020

1 result

Effect of enhanced masticatory force on OPG, RANKL and MGF in alveolar bone of ovariectomized rats.

Ma Z, Li S, Sun Y

Journal of applied oral science : revista FOB3 Apr 2020Cited by 6 (Europe PMC)

PMID32267378 (opens in a new tab)PMCIDPMC7135953 (opens in a new tab)DOI10.1590/1678-7757-2019-0409 (opens in a new tab)PepBankPUB-32267378
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Summary

BackgroundMenopause induces oral bone loss, leading to various oral diseases. Mastication importantly affects bone metabolism in the jawbone.ObjectiveTo analyze the effect of enhanced masticatory force on osteoprotegerin (OPG), receptor activator of nuclear factor kappa B ligand (RANKL), and mechano-growth factor (MGF) in alveolar bone of ovariectomized rats and to study the mechanics mechanism of the alveolar bone of ovariectomized rats response to enhanced masticatory force.MethodologyThirty Sprague Dawley rats were randomly divided into three groups: sham-operation group (fat around the removed ovary + normal hard diet), model group (ovariectomy + normal hard diet), and experimental group (ovariectomy + high hard diet). It was a 2-month experiment. Enzyme-linked immunosorbent assay (ELISA) detected serum estradiol (E2), osteocalcin (BGP) and alkaline phosphatase (ALP) in rats. Bone histomorphometric indices in the third molar region of maxilla were detected by micro-CT; protein expressions of OPG, RANKL, and MGF in the third molar region of maxilla was detected by Western blot; and gene expression of OPG, RANKL, and MGF in the third molar region of maxilla was detected by Quantitative Real-Time PCR.ResultsComparing with model group, serum E2 in experimental group increased but not significantly, serum BGP and serum ALP in experimental group decreased but not significantly, OPG in experimental group in alveolar bone increased significantly, RANKL in experimental group in alveolar bone decreased significantly, RANKL/OPG ratio in experimental group decreased significantly, MGF in experimental group in alveolar bone increased significantly, bone volume to total volume fraction increased significantly in experimental group, trabecular thickness increased significantly in experimental group, and trabecular separation decreased significantly in experimental group.ConclusionEnhanced masticatory force affected the expression of OPG, RANKL, and MGF in alveolar bone of ovariectomized rats, improved the quality of jaw bone of ovariectomized rats, and delayed oral bone loss by ovariectomy.
CC BYText from Europe PMC. Highlighted sentences are the source of results.

Results from this study1

No result from this study comes from a test of the peptide.

Natural levels measured1

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

  1. 01AnimalEndogenous levelAnimal study (in vivo)Mechanism

    In ovariectomized rats, a high hard diet significantly increased the body's own MGF in alveolar bone compared with a normal hard diet.

    In plain wordsIn rats with ovary removal, a harder diet raised the body's own MGF in jaw bone compared with a normal diet.

    Peptide
    MGF / PEG-MGF
    Outcome
    IncreaseMGF expression in alveolar bone
    Study

    ratn: not reported in source

    Ovariectomized Sprague Dawley rats
    Comparator
    Ovariectomy with normal hard diet (model group)
    Outcome group
    Bone and joint · Musculoskeletal

    Source sentences

    Summary
    MGF in experimental group in alveolar bone increased significantly
    1 context sentence
    Summary · context
    Thirty Sprague Dawley rats were randomly divided into three groups: sham-operation group (fat around the removed ovary + normal hard diet), model group (ovariectomy + normal hard diet), and experimental group (ovariectomy + high hard diet).

    This result measures the body's own MGF / PEG-MGF. Nobody was given the peptide. It is not evidence about taking it.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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