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Study · Animal study (in vivo) · mouse · 2020

1 result

Hypothalamic POMC deficiency increases circulating adiponectin despite obesity.

Yu H, Chhabra KH, Thompson Z, Jones GL, Kiran S, Shangguan G, Low MJ

Molecular metabolism7 Feb 2020Cited by 25 (Europe PMC)

PMID32244188 (opens in a new tab)PMCIDPMC7082555 (opens in a new tab)DOI10.1016/j.molmet.2020.01.021 (opens in a new tab)PepBankPUB-32244188
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: CC BY-NC-ND. Results still quote short attributed sentences.

Results from this study1

1 result from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Mechanism

    In Pomc-deficient female mice, acute melanotan II treatment reduced the raised plasma adiponectin to control littermate values.

    In plain wordsIn mice lacking Pomc in the hypothalamus, acute melanotan II lowered high adiponectin levels to the levels of control littermates.

    Peptide
    Melanotan II
    Outcome
    DecreasePlasma adiponectin after acute melanotan II in ArcPomc-/- female mice
    Study

    mousen: not reported in source

    ArcPomc-/- female mice
    Comparator
    Control littermate values
    Outcome group
    Receptor activity and mechanism · Endocrine and hormones
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Genetic restoration of Pomc expression in the Arc or acute treatment of the ArcPomc-/- female mice with melanotan II reduced adiponectin levels to control littermate values.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    10 Oct 2026, 09:43 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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