Cerebrolysin ameliorates prefrontal cortex and hippocampus neural atrophy of spontaneous hypertensive rats with hyperglycemia.

Aguilar-Hernández L, Gómez-Villalobos MJ, Flores G

Synapse (New York, N.Y.)29 Apr 2020Cited by 7 (Europe PMC)

PMID32232874DOI10.1002/syn.22156PepBankPUB-32232874

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Mechanism
In hyperglycemic hypertensive rats, results suggested that Cerebrolysin ameliorated the reduction in prefrontal cortical dendritic spine number.
In plain wordsIn hyperglycemic hypertensive rats, results suggested that Cerebrolysin reduced dendritic spine loss in the prefrontal cortex.
Peptide
Cerebrolysin
Outcome
IncreasePrefrontal cortical dendritic spines
Study
ratsn: not reported in source
Spontaneously hypertensive rats with streptozotocin-induced hyperglycemia
Outcome group
Neuroprotection · Nervous system and cognition
Studied dose
Dose not stated
Source sentences
Summary
Our results suggest that CBL ameliorated the reduction in the number of dendritic spines in the PFC and hippocampus caused by hyperglycemia in the SH rat.
2 context sentences(design, population, supporting numbers)
Summary · context
We studied these changes in an animal model with streptozotocin-induced diabetes mellitus in the spontaneous hypertensive (SH) rat.
Summary · context
In the present study, we evaluated the effect of CBL using the animal model with hyperglycemia and arterial hypertension and assessed the dendritic morphology using a Golgi-Cox staining procedure.
Report a problemFND-3223287401
02AnimalAnimal study (in vivo)Mechanism
In hyperglycemic hypertensive rats, results suggested that Cerebrolysin ameliorated the reduction in hippocampal dendritic spine number.
In plain wordsIn hyperglycemic hypertensive rats, results suggested that Cerebrolysin reduced dendritic spine loss in the hippocampus.
Peptide
Cerebrolysin
Outcome
IncreaseHippocampal dendritic spines
Study
ratsn: not reported in source
Spontaneously hypertensive rats with streptozotocin-induced hyperglycemia
Outcome group
Neuroprotection · Nervous system and cognition
Studied dose
Dose not stated
Source sentences
Summary
Our results suggest that CBL ameliorated the reduction in the number of dendritic spines in the PFC and hippocampus caused by hyperglycemia in the SH rat.
2 context sentences(design, population, supporting numbers)
Summary · context
We studied these changes in an animal model with streptozotocin-induced diabetes mellitus in the spontaneous hypertensive (SH) rat.
Summary · context
In the present study, we evaluated the effect of CBL using the animal model with hyperglycemia and arterial hypertension and assessed the dendritic morphology using a Golgi-Cox staining procedure.
Report a problemFND-3223287402
03AnimalAnimal study (in vivo)Mechanism
In hyperglycemic hypertensive rats, Cerebrolysin increased distal dendritic length in the prefrontal cortex.
In plain wordsIn hyperglycemic hypertensive rats, Cerebrolysin increased distal dendritic length in the prefrontal cortex.
Peptide
Cerebrolysin
Outcome
IncreasePrefrontal cortical distal dendritic length
Study
ratsn: not reported in source
Spontaneously hypertensive rats with streptozotocin-induced hyperglycemia
Outcome group
Neuroprotection · Nervous system and cognition
Studied dose
Dose not stated
Source sentences
Summary
In addition, CBL also increased distal dendritic length in the PFC and hippocampus in hyperglycemic SH rats.
2 context sentences(design, population, supporting numbers)
Summary · context
We studied these changes in an animal model with streptozotocin-induced diabetes mellitus in the spontaneous hypertensive (SH) rat.
Summary · context
In the present study, we evaluated the effect of CBL using the animal model with hyperglycemia and arterial hypertension and assessed the dendritic morphology using a Golgi-Cox staining procedure.
Report a problemFND-3223287403
04AnimalAnimal study (in vivo)Mechanism
In hyperglycemic hypertensive rats, Cerebrolysin increased distal dendritic length in the hippocampus.
In plain wordsIn hyperglycemic hypertensive rats, Cerebrolysin increased distal dendritic length in the hippocampus.
Peptide
Cerebrolysin
Outcome
IncreaseHippocampal distal dendritic length
Study
ratsn: not reported in source
Spontaneously hypertensive rats with streptozotocin-induced hyperglycemia
Outcome group
Neuroprotection · Nervous system and cognition
Studied dose
Dose not stated
Source sentences
Summary
In addition, CBL also increased distal dendritic length in the PFC and hippocampus in hyperglycemic SH rats.
2 context sentences(design, population, supporting numbers)
Summary · context
We studied these changes in an animal model with streptozotocin-induced diabetes mellitus in the spontaneous hypertensive (SH) rat.
Summary · context
In the present study, we evaluated the effect of CBL using the animal model with hyperglycemia and arterial hypertension and assessed the dendritic morphology using a Golgi-Cox staining procedure.
Report a problemFND-3223287404

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
14 Oct 2026, 05:02 UTC
Study results updated
Version 1
14 Oct 2026, 01:46 UTC
First added · source update from Europe PMC

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