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Study · In vitro (cells) · 2020

5 results

Mechano growth factor pretreatment yield mechanical stimuli induced cell stress responses in ligament fibroblasts of osteoarthritis via activating ATF-2.

Ma Y, Song Y, Li L, Dong L, Wang C, Wang P, Yang L

Biotechnology letters28 Mar 2020Cited by 2 (Europe PMC)

PMID32222864 (opens in a new tab)DOI10.1007/s10529-020-02866-5 (opens in a new tab)PepBankPUB-32222864
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

5 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Mechanism

    In osteoarthritis ligament fibroblasts, MGF pretreatment promoted timely feedback to mechanical stimuli by inducing cellular stress, whereas osteoarthritis delayed the response.

    In plain wordsIn knee ligament cells from osteoarthritis, MGF pretreatment helped cells respond in time to mechanical stress.

    Peptide
    MGF / PEG-MGF
    Outcome
    IncreaseCellular stress response to mechanical stimuli
    Study

    n: not reported in source

    Osteoarthritis ligament fibroblasts under 12% static mechanical stretch
    Comparator
    Stretch without MGF pretreatment
    Outcome group
    Tendon and ligament healing · Musculoskeletal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    We observed that OA delayed LFs response to mechanical injury, while MGF pretreatment promoted cells timely feedback the mechanically stimuli by inducing cellular stress.
    2 context sentences
    Summary · context
    Osteoarthritis ligament fibroblasts (OA-LFs) were suffered from 12% static mechanical stretch to mimic mechanical force mediated ligament injury.
    Summary · context
    Meanwhile, OA-LFs were treated with MGF before and during mechanical stretch.
  2. 02LabIn vitro (cells)Efficacy outcome

    In osteoarthritis ligament fibroblasts under stretch, MGF promoted cell migration.

    In plain wordsIn knee ligament cells under stretch, MGF increased cell movement.

    Peptide
    MGF / PEG-MGF
    Outcome
    IncreaseCell migration
    Study

    n: not reported in source

    Osteoarthritis ligament fibroblasts under 12% static mechanical stretch
    Comparator
    Stretch without MGF pretreatment
    Outcome group
    Tendon and ligament healing · Musculoskeletal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Additionally, MGF accelerated the ligament injury repair by promoting cell migration, decreasing the MMP-2 activity, and remitting the cell deformation via ATF-2 activating in cells.
    2 context sentences
    Summary · context
    Osteoarthritis ligament fibroblasts (OA-LFs) were suffered from 12% static mechanical stretch to mimic mechanical force mediated ligament injury.
    Summary · context
    Meanwhile, OA-LFs were treated with MGF before and during mechanical stretch.
  3. 03LabIn vitro (cells)Efficacy outcome

    In osteoarthritis ligament fibroblasts under stretch, MGF decreased MMP-2 activity.

    In plain wordsIn knee ligament cells under stretch, MGF lowered the activity of the enzyme MMP-2.

    Peptide
    MGF / PEG-MGF
    Outcome
    DecreaseMMP-2 activity
    Study

    n: not reported in source

    Osteoarthritis ligament fibroblasts under 12% static mechanical stretch
    Comparator
    Stretch without MGF pretreatment
    Outcome group
    Tendon and ligament healing · Musculoskeletal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Additionally, MGF accelerated the ligament injury repair by promoting cell migration, decreasing the MMP-2 activity, and remitting the cell deformation via ATF-2 activating in cells.
    2 context sentences
    Summary · context
    Osteoarthritis ligament fibroblasts (OA-LFs) were suffered from 12% static mechanical stretch to mimic mechanical force mediated ligament injury.
    Summary · context
    Meanwhile, OA-LFs were treated with MGF before and during mechanical stretch.
  4. 04LabIn vitro (cells)Efficacy outcome

    In osteoarthritis ligament fibroblasts under stretch, MGF remitted cell deformation.

    In plain wordsIn knee ligament cells under stretch, MGF reduced stretch-induced changes in cell shape.

    Peptide
    MGF / PEG-MGF
    Outcome
    DecreaseCell deformation
    Study

    n: not reported in source

    Osteoarthritis ligament fibroblasts under 12% static mechanical stretch
    Comparator
    Stretch without MGF pretreatment
    Outcome group
    Tendon and ligament healing · Musculoskeletal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Additionally, MGF accelerated the ligament injury repair by promoting cell migration, decreasing the MMP-2 activity, and remitting the cell deformation via ATF-2 activating in cells.
    2 context sentences
    Summary · context
    Osteoarthritis ligament fibroblasts (OA-LFs) were suffered from 12% static mechanical stretch to mimic mechanical force mediated ligament injury.
    Summary · context
    Meanwhile, OA-LFs were treated with MGF before and during mechanical stretch.
  5. 05LabIn vitro (cells)Mechanism

    In osteoarthritis ligament fibroblasts under stretch, MGF acted through activation of ATF-2 to accelerate ligament injury repair.

    In plain wordsIn knee ligament cells under stretch, MGF worked through ATF-2 activation to speed repair.

    Peptide
    MGF / PEG-MGF
    Outcome
    IncreaseATF-2 activation
    Study

    n: not reported in source

    Osteoarthritis ligament fibroblasts under 12% static mechanical stretch
    Comparator
    Stretch without MGF pretreatment
    Outcome group
    Receptor activity and mechanism · Musculoskeletal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Additionally, MGF accelerated the ligament injury repair by promoting cell migration, decreasing the MMP-2 activity, and remitting the cell deformation via ATF-2 activating in cells.
    2 context sentences
    Summary · context
    Osteoarthritis ligament fibroblasts (OA-LFs) were suffered from 12% static mechanical stretch to mimic mechanical force mediated ligament injury.
    Summary · context
    Meanwhile, OA-LFs were treated with MGF before and during mechanical stretch.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

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