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Study · Randomized controlled trial · n = 96 · 2020

8 results

The Impact of Oxytocin Vaginal Gel on Sexual Function in Postmenopausal Women: A Randomized Controlled Trial.

Abedi P, Zohrabi I, Ansari S, Maraghi E, Maram NS, Houshmand G

Journal of sex & marital therapy13 Mar 2020Cited by 11 (Europe PMC)

PMID32169019 (opens in a new tab)DOI10.1080/0092623x.2020.1738606 (opens in a new tab)PepBankPUB-32169019
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study8

8 results from studies that gave the peptide. 8 results from people.

  1. 01HumanRandomized controlled trialEfficacy outcome

    In postmenopausal women with vaginal atrophy, oxytocin vaginal gel improved the vaginal maturation index compared with placebo.

    In plain wordsIn postmenopausal women, oxytocin vaginal gel improved the vaginal maturation index more than placebo.

    Peptide
    Oxytocin
    Outcome
    Direction not reportedVaginal maturation index
    Study

    n = 96

    Comparator
    Placebo
    Outcome group
    Vaginal and urogenital health · Reproductive and sexual health
    Studied dose
    400 IU · vaginalAs given in this study (human).

    Source sentences

    Summary
    The vaginal maturation index and the PH of the vagina improved in the oxytocin group
    1 context sentence
    Summary · context
    This study was conducted on 96 postmenopausal women with symptoms of vaginal atrophy and sexual dysfunction who were randomly recruited into two groups of oxytocin vaginal gel (400 IU, n = 48) or placebo (n = 48).
  2. 02HumanRandomized controlled trialEfficacy outcome

    In postmenopausal women with vaginal atrophy, oxytocin vaginal gel improved vaginal pH compared with placebo.

    In plain wordsIn postmenopausal women, oxytocin vaginal gel improved vaginal pH more than placebo.

    Peptide
    Oxytocin
    Outcome
    Direction not reportedVaginal pH
    Study

    n = 96

    Comparator
    Placebo
    Outcome group
    Vaginal and urogenital health · Reproductive and sexual health
    Studied dose
    400 IU · vaginalAs given in this study (human).

    Source sentences

    Summary
    The vaginal maturation index and the PH of the vagina improved in the oxytocin group compared to those of the placebo.
    1 context sentence
    Summary · context
    This study was conducted on 96 postmenopausal women with symptoms of vaginal atrophy and sexual dysfunction who were randomly recruited into two groups of oxytocin vaginal gel (400 IU, n = 48) or placebo (n = 48).
  3. 03HumanRandomized controlled trialEfficacy outcome

    In postmenopausal women with sexual dysfunction, oxytocin vaginal gel improved the desire domain of sexual function compared with placebo.

    In plain wordsIn postmenopausal women, oxytocin vaginal gel improved sexual desire scores more than placebo.

    Peptide
    Oxytocin
    Outcome
    Direction not reportedSexual desire (FSFI domain)
    Study

    n = 96

    Comparator
    Placebo
    Outcome group
    Sexual function · Reproductive and sexual health
    Studied dose
    400 IU · vaginalAs given in this study (human).

    Source sentences

    Summary
    All domains of sexual function including desire, arousal, lubrication, pain, sexual satisfaction, and total score of sexual function improved significantly in the oxytocin gel compared to the control group (p < 0.0001).
    1 context sentence
    Summary · context
    This study was conducted on 96 postmenopausal women with symptoms of vaginal atrophy and sexual dysfunction who were randomly recruited into two groups of oxytocin vaginal gel (400 IU, n = 48) or placebo (n = 48).
  4. 04HumanRandomized controlled trialEfficacy outcome

    In postmenopausal women with sexual dysfunction, oxytocin vaginal gel improved the arousal domain of sexual function compared with placebo.

    In plain wordsIn postmenopausal women, oxytocin vaginal gel improved sexual arousal scores more than placebo.

    Peptide
    Oxytocin
    Outcome
    Direction not reportedSexual arousal (FSFI domain)
    Study

    n = 96

    Comparator
    Placebo
    Outcome group
    Sexual function · Reproductive and sexual health
    Studied dose
    400 IU · vaginalAs given in this study (human).

    Source sentences

    Summary
    All domains of sexual function including desire, arousal, lubrication, pain, sexual satisfaction, and total score of sexual function improved significantly in the oxytocin gel compared to the control group (p < 0.0001).
    1 context sentence
    Summary · context
    This study was conducted on 96 postmenopausal women with symptoms of vaginal atrophy and sexual dysfunction who were randomly recruited into two groups of oxytocin vaginal gel (400 IU, n = 48) or placebo (n = 48).
  5. 05HumanRandomized controlled trialEfficacy outcome

    In postmenopausal women with sexual dysfunction, oxytocin vaginal gel improved the lubrication domain of sexual function compared with placebo.

    In plain wordsIn postmenopausal women, oxytocin vaginal gel improved lubrication scores more than placebo.

    Peptide
    Oxytocin
    Outcome
    Direction not reportedLubrication (FSFI domain)
    Study

    n = 96

    Comparator
    Placebo
    Outcome group
    Sexual function · Reproductive and sexual health
    Studied dose
    400 IU · vaginalAs given in this study (human).

    Source sentences

    Summary
    All domains of sexual function including desire, arousal, lubrication, pain, sexual satisfaction, and total score of sexual function improved significantly in the oxytocin gel compared to the control group (p < 0.0001).
    1 context sentence
    Summary · context
    This study was conducted on 96 postmenopausal women with symptoms of vaginal atrophy and sexual dysfunction who were randomly recruited into two groups of oxytocin vaginal gel (400 IU, n = 48) or placebo (n = 48).
  6. 06HumanRandomized controlled trialEfficacy outcome

    In postmenopausal women with sexual dysfunction, oxytocin vaginal gel improved the pain domain of sexual function compared with placebo.

    In plain wordsIn postmenopausal women, oxytocin vaginal gel improved sexual pain scores more than placebo.

    Peptide
    Oxytocin
    Outcome
    Direction not reportedSexual pain (FSFI domain)
    Study

    n = 96

    Comparator
    Placebo
    Outcome group
    Sexual function · Reproductive and sexual health
    Studied dose
    400 IU · vaginalAs given in this study (human).

    Source sentences

    Summary
    All domains of sexual function including desire, arousal, lubrication, pain, sexual satisfaction, and total score of sexual function improved significantly in the oxytocin gel compared to the control group (p < 0.0001).
    1 context sentence
    Summary · context
    This study was conducted on 96 postmenopausal women with symptoms of vaginal atrophy and sexual dysfunction who were randomly recruited into two groups of oxytocin vaginal gel (400 IU, n = 48) or placebo (n = 48).
  7. 07HumanRandomized controlled trialEfficacy outcome

    In postmenopausal women with sexual dysfunction, oxytocin vaginal gel improved the sexual satisfaction domain compared with placebo.

    In plain wordsIn postmenopausal women, oxytocin vaginal gel improved sexual satisfaction scores more than placebo.

    Peptide
    Oxytocin
    Outcome
    Direction not reportedSexual satisfaction (FSFI domain)
    Study

    n = 96

    Comparator
    Placebo
    Outcome group
    Sexual function · Reproductive and sexual health
    Studied dose
    400 IU · vaginalAs given in this study (human).

    Source sentences

    Summary
    All domains of sexual function including desire, arousal, lubrication, pain, sexual satisfaction, and total score of sexual function improved significantly in the oxytocin gel compared to the control group (p < 0.0001).
    1 context sentence
    Summary · context
    This study was conducted on 96 postmenopausal women with symptoms of vaginal atrophy and sexual dysfunction who were randomly recruited into two groups of oxytocin vaginal gel (400 IU, n = 48) or placebo (n = 48).
  8. 08HumanRandomized controlled trialEfficacy outcome

    In postmenopausal women with sexual dysfunction, oxytocin vaginal gel improved the total sexual function score compared with placebo.

    In plain wordsIn postmenopausal women, oxytocin vaginal gel improved the total sexual function score more than placebo.

    Peptide
    Oxytocin
    Outcome
    Direction not reportedTotal sexual function score (FSFI)
    Study

    n = 96

    Comparator
    Placebo
    Outcome group
    Sexual function · Reproductive and sexual health
    Studied dose
    400 IU · vaginalAs given in this study (human).

    Source sentences

    Summary
    All domains of sexual function including desire, arousal, lubrication, pain, sexual satisfaction, and total score of sexual function improved significantly in the oxytocin gel compared to the control group (p < 0.0001).
    1 context sentence
    Summary · context
    This study was conducted on 96 postmenopausal women with symptoms of vaginal atrophy and sexual dysfunction who were randomly recruited into two groups of oxytocin vaginal gel (400 IU, n = 48) or placebo (n = 48).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 00:50 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:48 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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