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Study · Systematic review · 2020

2 results

Intranasal oxytocin as a potential therapeutic strategy in post-traumatic stress disorder: A systematic review.

Giovanna G, Damiani S, Fusar-Poli L, Rocchetti M, Brondino N, de Cagna F, Mori A, Politi P

Psychoneuroendocrinology7 Feb 2020Cited by 36 (Europe PMC)

PMID32088633 (opens in a new tab)DOI10.1016/j.psyneuen.2020.104605 (opens in a new tab)PepBankPUB-32088633
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

2 results from studies that gave the peptide. 2 results from people.

  1. 01HumanSystematic reviewEfficacy outcome

    In a systematic review of fourteen studies in patients with PTSD, results for intranasal oxytocin were mixed and insufficient to quantify effectiveness.

    In plain wordsIn a review of fourteen studies in people with PTSD, results for oxytocin spray were mixed and too limited to judge benefit.

    Peptide
    Oxytocin
    Outcome
    MixedEffectiveness of intranasal oxytocin on PTSD symptoms
    Study

    n: not reported in source

    Outcome group
    Anxiety and mood · Mental health and mood
    Studied dose
    Dose not stated · intranasalAs given in this study (human).

    Source sentences

    Summary
    The fourteen studies included in the present review provide tentative evidence that INOT could be a safe pharmacological intervention, although the results were mixed and insufficient to quantify the effectiveness of this intervention.
    1 context sentence
    Summary · context
    In this systematic review, the potential effects of intranasal OT (INOT) administration on core symptoms in PTSD patients are discussed, as well as neurobiological correlates in functional imaging supporting its clinical evidence.
  2. 02HumanSystematic reviewSafety outcome

    In a systematic review of fourteen studies in patients with PTSD, tentative evidence suggested that intranasal oxytocin could be a safe intervention.

    In plain wordsIn a review of fourteen studies in people with PTSD, there was tentative evidence that oxytocin spray could be safe.

    Peptide
    Oxytocin
    Outcome
    Direction not reportedSafety of intranasal oxytocin in PTSD
    Study

    n: not reported in source

    Outcome group
    Adverse events · Mental health and mood
    Studied dose
    Dose not stated · intranasalAs given in this study (human).

    Source sentences

    Summary
    The fourteen studies included in the present review provide tentative evidence that INOT could be a safe pharmacological intervention, although the results were mixed and insufficient to quantify the effectiveness of this intervention.
    1 context sentence
    Summary · context
    In this systematic review, the potential effects of intranasal OT (INOT) administration on core symptoms in PTSD patients are discussed, as well as neurobiological correlates in functional imaging supporting its clinical evidence.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 00:50 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:49 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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