AEDG Peptide (Epitalon) Stimulates Gene Expression and Protein Synthesis during Neurogenesis: Possible Epigenetic Mechanism.

Khavinson V, Diomede F, Mironova E, Linkova N, Trofimova S, Trubiani O, Caputi S, Sinjari B

Molecules (Basel, Switzerland)30 Jan 2020Cited by 22 (Europe PMC)

PMID32019204PMCIDPMC7037223DOI10.3390/molecules25030609PepBankPUB-32019204

Summary

It was shown that AEDG peptide (Ala-Glu-Asp-Gly, Epitalon) regulates the function of the pineal gland, the retina, and the brain. AEDG peptide increases longevity in animals and decreases experimental cancerogenesis. AEDG peptide induces neuronal cell differentiation in retinal and human periodontal ligament stem cells. The aim of the study was to investigate the influence of AEDG peptide on neurogenic differentiation gene expression and protein synthesis in human gingival mesenchymal stem cells, and to suggest the basis for the epigenetic mechanism of this process. AEDG peptide increased the synthesis of neurogenic differentiation markers: Nestin, GAP43, β Tubulin III, Doublecortin in hGMSCs. AEDG peptide increased Nestin, GAP43, β Tubulin III and Doublecortin mRNA expression by 1.6-1.8 times in hGMSCs. Molecular modelling method showed, that AEDG peptide preferably binds with H1/6 and H1/3 histones in His-Pro-Ser-Tyr-Met-Ala-His-Pro-Ala-Arg-Lys and Tyr-Arg-Lys-Thr-Gln sites, which interact with DNA. These results correspond to previous experimental data. AEDG peptide and histones H1/3, H1/6 binding may be one of the mechanisms which provides an increase of Nestin, GAP43, β Tubulin III, and Doublecortin neuronal differentiation gene transcription. AEDG peptide can epigenetically regulate neuronal differentiation gene expression and protein synthesis in human stem cells.

CC BYText from Europe PMC. Highlighted sentences are the source of results.

Results from this study9

9 results from studies that gave the peptide. No result from this study comes from people.

01LabIn vitro (cells)Mechanism
In human gingival mesenchymal stem cells, AEDG peptide (Epitalon) increased synthesis of the neurogenic marker Nestin.
In plain wordsIn human gum stem cells in the lab, Epitalon raised production of the neuron marker Nestin.
Peptide
Epitalon
Outcome
IncreaseNestin protein synthesis
Study
humann: not reported in source
Human gingival mesenchymal stem cells (hGMSCs)
Outcome group
Neuroprotection · Nervous system and cognition
Studied dose
Dose not stated
Source sentences
Summary
AEDG peptide increased the synthesis of neurogenic differentiation markers: Nestin, GAP43, β Tubulin III, Doublecortin in hGMSCs.
1 context sentence(design, population, supporting numbers)
Summary · context
The aim of the study was to investigate the influence of AEDG peptide on neurogenic differentiation gene expression and protein synthesis in human gingival mesenchymal stem cells, and to suggest the basis for the epigenetic mechanism of this process.
Show in the study text Report a problemFND-3201920401
02LabIn vitro (cells)Mechanism
In human gingival mesenchymal stem cells, AEDG peptide (Epitalon) increased synthesis of the neurogenic marker GAP43.
In plain wordsIn human gum stem cells in the lab, Epitalon raised production of the neuron marker GAP43.
Peptide
Epitalon
Outcome
IncreaseGAP43 protein synthesis
Study
humann: not reported in source
Human gingival mesenchymal stem cells (hGMSCs)
Outcome group
Neuroprotection · Nervous system and cognition
Studied dose
Dose not stated
Source sentences
Summary
AEDG peptide increased the synthesis of neurogenic differentiation markers: Nestin, GAP43, β Tubulin III, Doublecortin in hGMSCs.
1 context sentence(design, population, supporting numbers)
Summary · context
The aim of the study was to investigate the influence of AEDG peptide on neurogenic differentiation gene expression and protein synthesis in human gingival mesenchymal stem cells, and to suggest the basis for the epigenetic mechanism of this process.
Show in the study text Report a problemFND-3201920402
03LabIn vitro (cells)Mechanism
In human gingival mesenchymal stem cells, AEDG peptide (Epitalon) increased synthesis of the neurogenic marker β Tubulin III.
In plain wordsIn human gum stem cells in the lab, Epitalon raised production of the neuron marker β Tubulin III.
Peptide
Epitalon
Outcome
IncreaseBeta Tubulin III protein synthesis
Study
humann: not reported in source
Human gingival mesenchymal stem cells (hGMSCs)
Outcome group
Neuroprotection · Nervous system and cognition
Studied dose
Dose not stated
Source sentences
Summary
AEDG peptide increased the synthesis of neurogenic differentiation markers: Nestin, GAP43, β Tubulin III, Doublecortin in hGMSCs.
1 context sentence(design, population, supporting numbers)
Summary · context
The aim of the study was to investigate the influence of AEDG peptide on neurogenic differentiation gene expression and protein synthesis in human gingival mesenchymal stem cells, and to suggest the basis for the epigenetic mechanism of this process.
Show in the study text Report a problemFND-3201920403
04LabIn vitro (cells)Mechanism
In human gingival mesenchymal stem cells, AEDG peptide (Epitalon) increased synthesis of the neurogenic marker Doublecortin.
In plain wordsIn human gum stem cells in the lab, Epitalon raised production of the neuron marker Doublecortin.
Peptide
Epitalon
Outcome
IncreaseDoublecortin protein synthesis
Study
humann: not reported in source
Human gingival mesenchymal stem cells (hGMSCs)
Outcome group
Neuroprotection · Nervous system and cognition
Studied dose
Dose not stated
Source sentences
Summary
AEDG peptide increased the synthesis of neurogenic differentiation markers: Nestin, GAP43, β Tubulin III, Doublecortin in hGMSCs.
1 context sentence(design, population, supporting numbers)
Summary · context
The aim of the study was to investigate the influence of AEDG peptide on neurogenic differentiation gene expression and protein synthesis in human gingival mesenchymal stem cells, and to suggest the basis for the epigenetic mechanism of this process.
Show in the study text Report a problemFND-3201920404
05LabIn vitro (cells)Mechanism
In human gingival mesenchymal stem cells, AEDG peptide increased Nestin mRNA expression by 1.6-1.8 times.
In plain wordsIn human gum stem cells in the lab, Epitalon raised Nestin gene expression by about 1.6 to 1.8 times.
Peptide
Epitalon
Outcome
IncreaseNestin mRNA expression
Study
humann: not reported in source
Human gingival mesenchymal stem cells (hGMSCs)
Outcome group
Neuroprotection · Nervous system and cognition
Studied dose
Dose not stated
Measurements
mRNA fold increase
1.6 to 1.8 times
hGMSCs
Source sentences
Summary
AEDG peptide increased Nestin, GAP43, β Tubulin III and Doublecortin mRNA expression by 1.6-1.8 times in hGMSCs.
1 context sentence(design, population, supporting numbers)
Summary · context
The aim of the study was to investigate the influence of AEDG peptide on neurogenic differentiation gene expression and protein synthesis in human gingival mesenchymal stem cells, and to suggest the basis for the epigenetic mechanism of this process.
Show in the study text Report a problemFND-3201920405
06LabIn vitro (cells)Mechanism
In human gingival mesenchymal stem cells, AEDG peptide increased GAP43 mRNA expression by 1.6-1.8 times.
In plain wordsIn human gum stem cells in the lab, Epitalon raised GAP43 gene expression by about 1.6 to 1.8 times.
Peptide
Epitalon
Outcome
IncreaseGAP43 mRNA expression
Study
humann: not reported in source
Human gingival mesenchymal stem cells (hGMSCs)
Outcome group
Neuroprotection · Nervous system and cognition
Studied dose
Dose not stated
Measurements
mRNA fold increase
1.6 to 1.8 times
hGMSCs
Source sentences
Summary
AEDG peptide increased Nestin, GAP43, β Tubulin III and Doublecortin mRNA expression by 1.6-1.8 times in hGMSCs.
1 context sentence(design, population, supporting numbers)
Summary · context
The aim of the study was to investigate the influence of AEDG peptide on neurogenic differentiation gene expression and protein synthesis in human gingival mesenchymal stem cells, and to suggest the basis for the epigenetic mechanism of this process.
Show in the study text Report a problemFND-3201920406
07LabIn vitro (cells)Mechanism
In human gingival mesenchymal stem cells, AEDG peptide increased β Tubulin III mRNA expression by 1.6-1.8 times.
In plain wordsIn human gum stem cells in the lab, Epitalon raised β Tubulin III gene expression by about 1.6 to 1.8 times.
Peptide
Epitalon
Outcome
IncreaseBeta Tubulin III mRNA expression
Study
humann: not reported in source
Human gingival mesenchymal stem cells (hGMSCs)
Outcome group
Neuroprotection · Nervous system and cognition
Studied dose
Dose not stated
Measurements
mRNA fold increase
1.6 to 1.8 times
hGMSCs
Source sentences
Summary
AEDG peptide increased Nestin, GAP43, β Tubulin III and Doublecortin mRNA expression by 1.6-1.8 times in hGMSCs.
1 context sentence(design, population, supporting numbers)
Summary · context
The aim of the study was to investigate the influence of AEDG peptide on neurogenic differentiation gene expression and protein synthesis in human gingival mesenchymal stem cells, and to suggest the basis for the epigenetic mechanism of this process.
Show in the study text Report a problemFND-3201920407
08LabIn vitro (cells)Mechanism
In human gingival mesenchymal stem cells, AEDG peptide increased Doublecortin mRNA expression by 1.6-1.8 times.
In plain wordsIn human gum stem cells in the lab, Epitalon raised Doublecortin gene expression by about 1.6 to 1.8 times.
Peptide
Epitalon
Outcome
IncreaseDoublecortin mRNA expression
Study
humann: not reported in source
Human gingival mesenchymal stem cells (hGMSCs)
Outcome group
Neuroprotection · Nervous system and cognition
Studied dose
Dose not stated
Measurements
mRNA fold increase
1.6 to 1.8 times
hGMSCs
Source sentences
Summary
AEDG peptide increased Nestin, GAP43, β Tubulin III and Doublecortin mRNA expression by 1.6-1.8 times in hGMSCs.
1 context sentence(design, population, supporting numbers)
Summary · context
The aim of the study was to investigate the influence of AEDG peptide on neurogenic differentiation gene expression and protein synthesis in human gingival mesenchymal stem cells, and to suggest the basis for the epigenetic mechanism of this process.
Show in the study text Report a problemFND-3201920408
09Computer modelIn silicoMechanism
Molecular modelling predicted that AEDG peptide binds preferably to histones H1/6 and H1/3 at sites that interact with DNA.
In plain wordsA computer model predicted that Epitalon binds to certain histone proteins that interact with DNA.
Peptide
Epitalon
Outcome
Not applicablePredicted binding to histones H1/6 and H1/3
Study
n: not reported in source
Molecular modelling
Outcome group
Receptor activity and mechanism · Nervous system and cognition
Studied dose
Dose not stated
Source sentences
Summary
Molecular modelling method showed, that AEDG peptide preferably binds with H1/6 and H1/3 histones in His-Pro-Ser-Tyr-Met-Ala-His-Pro-Ala-Arg-Lys and Tyr-Arg-Lys-Thr-Gln sites, which interact with DNA.
Show in the study text Report a problemFND-3201920409

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
9 Oct 2026, 18:17 UTC
Study results updated
Version 1
9 Oct 2026, 02:47 UTC
First added · source update from Europe PMC

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Terms as the source lists them.

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