[Cerebrolysin peptides as mood stabilizers].

Torshin IY, Gromova OA, Zgoda VG, Tikhonova OV, Malyavskaya SI

Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova1 Jan 2019

PMID31994517DOI10.17116/jnevro201911912169PepBankPUB-31994517

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study11

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone11

In this study, Cerebrolysin was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Cerebrolysin.

01LabNot a test of Cerebrolysin aloneIn vitro (cell-free)Other
Mass spectrometry identified enkephalins, partial enkephalin analogues, and beta-lipotropin fragments in Cerebrolysin.
In plain wordsIn lab tests, Cerebrolysin contained enkephalins, their partial analogues, and beta-lipotropin fragments.
Peptide
Cerebrolysin
Outcome
Not applicablePeptide composition
Study
n: not reported in source
Outcome group
Product quality and purity · Pharmacology
Source sentences
Summary
Cerebrolysin contains considerable amounts of Leu- and Met-enkephalins, partial analogues of enkephalins, peptide fragments of beta-lipotropin.
1 context sentence(design, population, supporting numbers)
Summary · context
Mass-spectrometric analysis of the peptide composition of cerebrolysin followed by a complex bioinformatics analysis was utilized.
In this study, Cerebrolysin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Cerebrolysin.
Report a problemFND-3199451701
02Computer modelNot a test of Cerebrolysin aloneIn silicoMechanism
Bioinformatics analysis attributed endorphinergic stimulation to Cerebrolysin peptides.
In plain wordsComputer analysis suggested that Cerebrolysin peptides stimulate the endorphinergic system.
Peptide
Cerebrolysin
Outcome
IncreaseEndorphinergic stimulation
Study
n: not reported in source
Outcome group
Receptor activity and mechanism · Nervous system and cognition
Source sentences
Summary
These peptides stimulate the endorphinergic system thus contributing to normothymic action and an increase in the levels of the brain-derived neurotrophic factor (BDNF).
1 context sentence(design, population, supporting numbers)
Summary · context
Mass-spectrometric analysis of the peptide composition of cerebrolysin followed by a complex bioinformatics analysis was utilized.
In this study, Cerebrolysin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Cerebrolysin.
Report a problemFND-3199451702
03Computer modelNot a test of Cerebrolysin aloneIn silicoMechanism
Bioinformatics analysis linked Cerebrolysin peptides to increased BDNF levels.
In plain wordsComputer analysis linked Cerebrolysin peptides to higher BDNF levels.
Peptide
Cerebrolysin
Outcome
IncreaseBDNF levels
Study
n: not reported in source
Outcome group
Neuroprotection · Nervous system and cognition
Source sentences
Summary
These peptides stimulate the endorphinergic system thus contributing to normothymic action and an increase in the levels of the brain-derived neurotrophic factor (BDNF).
1 context sentence(design, population, supporting numbers)
Summary · context
Mass-spectrometric analysis of the peptide composition of cerebrolysin followed by a complex bioinformatics analysis was utilized.
In this study, Cerebrolysin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Cerebrolysin.
Report a problemFND-3199451703
04Computer modelNot a test of Cerebrolysin aloneIn silicoMechanism
Bioinformatics analysis attributed ABL1 inhibition to Cerebrolysin peptides.
In plain wordsComputer analysis suggested that Cerebrolysin peptides inhibit ABL1.
Peptide
Cerebrolysin
Outcome
DecreaseABL1 inhibition
Study
n: not reported in source
Outcome group
Receptor activity and mechanism · Nervous system and cognition
Source sentences
Summary
Specific inhibition of kinases ABL1, PINK1, CDK5 and arginine N-methyltransferase PRMT5 by the peptides of cerebrolysin has a multidirectional effect on the dopaminergic system, also helping to stabilize mood.
1 context sentence(design, population, supporting numbers)
Summary · context
Mass-spectrometric analysis of the peptide composition of cerebrolysin followed by a complex bioinformatics analysis was utilized.
In this study, Cerebrolysin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Cerebrolysin.
Report a problemFND-3199451704
05Computer modelNot a test of Cerebrolysin aloneIn silicoMechanism
Bioinformatics analysis attributed PINK1 inhibition to Cerebrolysin peptides.
In plain wordsComputer analysis suggested that Cerebrolysin peptides inhibit PINK1.
Peptide
Cerebrolysin
Outcome
DecreasePINK1 inhibition
Study
n: not reported in source
Outcome group
Receptor activity and mechanism · Nervous system and cognition
Source sentences
Summary
Specific inhibition of kinases ABL1, PINK1, CDK5 and arginine N-methyltransferase PRMT5 by the peptides of cerebrolysin has a multidirectional effect on the dopaminergic system, also helping to stabilize mood.
1 context sentence(design, population, supporting numbers)
Summary · context
Mass-spectrometric analysis of the peptide composition of cerebrolysin followed by a complex bioinformatics analysis was utilized.
In this study, Cerebrolysin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Cerebrolysin.
Report a problemFND-3199451705
06Computer modelNot a test of Cerebrolysin aloneIn silicoMechanism
Bioinformatics analysis attributed CDK5 inhibition to Cerebrolysin peptides.
In plain wordsComputer analysis suggested that Cerebrolysin peptides inhibit CDK5.
Peptide
Cerebrolysin
Outcome
DecreaseCDK5 inhibition
Study
n: not reported in source
Outcome group
Receptor activity and mechanism · Nervous system and cognition
Source sentences
Summary
Specific inhibition of kinases ABL1, PINK1, CDK5 and arginine N-methyltransferase PRMT5 by the peptides of cerebrolysin has a multidirectional effect on the dopaminergic system, also helping to stabilize mood.
1 context sentence(design, population, supporting numbers)
Summary · context
Mass-spectrometric analysis of the peptide composition of cerebrolysin followed by a complex bioinformatics analysis was utilized.
In this study, Cerebrolysin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Cerebrolysin.
Report a problemFND-3199451706
07Computer modelNot a test of Cerebrolysin aloneIn silicoMechanism
Bioinformatics analysis attributed PRMT5 inhibition to Cerebrolysin peptides.
In plain wordsComputer analysis suggested that Cerebrolysin peptides inhibit PRMT5.
Peptide
Cerebrolysin
Outcome
DecreasePRMT5 inhibition
Study
n: not reported in source
Outcome group
Receptor activity and mechanism · Nervous system and cognition
Source sentences
Summary
Specific inhibition of kinases ABL1, PINK1, CDK5 and arginine N-methyltransferase PRMT5 by the peptides of cerebrolysin has a multidirectional effect on the dopaminergic system, also helping to stabilize mood.
1 context sentence(design, population, supporting numbers)
Summary · context
Mass-spectrometric analysis of the peptide composition of cerebrolysin followed by a complex bioinformatics analysis was utilized.
In this study, Cerebrolysin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Cerebrolysin.
Report a problemFND-3199451707
08Computer modelNot a test of Cerebrolysin aloneIn silicoMechanism
Bioinformatics analysis attributed multidirectional dopaminergic effects to Cerebrolysin peptides.
In plain wordsComputer analysis suggested that Cerebrolysin peptides affect the dopaminergic system in several directions.
Peptide
Cerebrolysin
Outcome
MixedDopaminergic modulation
Study
n: not reported in source
Outcome group
Receptor activity and mechanism · Nervous system and cognition
Source sentences
Summary
Specific inhibition of kinases ABL1, PINK1, CDK5 and arginine N-methyltransferase PRMT5 by the peptides of cerebrolysin has a multidirectional effect on the dopaminergic system, also helping to stabilize mood.
1 context sentence(design, population, supporting numbers)
Summary · context
Mass-spectrometric analysis of the peptide composition of cerebrolysin followed by a complex bioinformatics analysis was utilized.
In this study, Cerebrolysin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Cerebrolysin.
Report a problemFND-3199451708
09Computer modelNot a test of Cerebrolysin aloneIn silicoMechanism
Bioinformatics analysis reported no direct Cerebrolysin peptide effects on the serotonergic system.
In plain wordsComputer analysis reported no direct Cerebrolysin peptide effects on the serotonergic system.
Peptide
Cerebrolysin
Outcome
No significant changeDirect serotonergic effects
Study
n: not reported in source
Outcome group
Receptor activity and mechanism · Nervous system and cognition
Source sentences
Summary
Cerebrolysin peptides do not directly affect neither the serotonergic, adrenergic, nor GABAergic systems.
1 context sentence(design, population, supporting numbers)
Summary · context
Mass-spectrometric analysis of the peptide composition of cerebrolysin followed by a complex bioinformatics analysis was utilized.
In this study, Cerebrolysin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Cerebrolysin.
Report a problemFND-3199451709
10Computer modelNot a test of Cerebrolysin aloneIn silicoMechanism
Bioinformatics analysis reported no direct Cerebrolysin peptide effects on the adrenergic system.
In plain wordsComputer analysis reported no direct Cerebrolysin peptide effects on the adrenergic system.
Peptide
Cerebrolysin
Outcome
No significant changeDirect adrenergic effects
Study
n: not reported in source
Outcome group
Receptor activity and mechanism · Nervous system and cognition
Source sentences
Summary
Cerebrolysin peptides do not directly affect neither the serotonergic, adrenergic, nor GABAergic systems.
1 context sentence(design, population, supporting numbers)
Summary · context
Mass-spectrometric analysis of the peptide composition of cerebrolysin followed by a complex bioinformatics analysis was utilized.
In this study, Cerebrolysin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Cerebrolysin.
Report a problemFND-3199451710
11Computer modelNot a test of Cerebrolysin aloneIn silicoMechanism
Bioinformatics analysis reported no direct Cerebrolysin peptide effects on the GABAergic system.
In plain wordsComputer analysis reported no direct Cerebrolysin peptide effects on the GABAergic system.
Peptide
Cerebrolysin
Outcome
No significant changeDirect GABAergic effects
Study
n: not reported in source
Outcome group
Receptor activity and mechanism · Nervous system and cognition
Source sentences
Summary
Cerebrolysin peptides do not directly affect neither the serotonergic, adrenergic, nor GABAergic systems.
1 context sentence(design, population, supporting numbers)
Summary · context
Mass-spectrometric analysis of the peptide composition of cerebrolysin followed by a complex bioinformatics analysis was utilized.
In this study, Cerebrolysin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Cerebrolysin.
Report a problemFND-3199451711

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
14 Oct 2026, 05:02 UTC
Study results updated
Version 1
14 Oct 2026, 01:46 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

Journal Article

MeSH terms

Keywords

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