Cerebrolysin prevents sleep deprivation induced memory impairment and oxidative stress.

Alzoubi KH, Al-Jamal FF, Mahasneh AF

Physiology & behavior25 Jan 2020Cited by 38 (Europe PMC)

PMID31987894DOI10.1016/j.physbeh.2020.112823PepBankPUB-31987894

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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study7

7 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Efficacy outcome
In sleep-deprived rats, Cerebrolysin prevented short-term memory impairment compared with sleep deprivation without Cerebrolysin.
In plain wordsIn sleep-deprived rats, Cerebrolysin prevented short-term memory impairment compared with sleep deprivation without Cerebrolysin.
Peptide
Cerebrolysin
Outcome
IncreaseShort-term memory
Study
ratsn: not reported in source
Sleep deprivation by modified multiple platform model
Comparator
Sleep deprivation without Cerebrolysin
Outcome group
Cognition and memory · Nervous system and cognition
Studied dose
Dose not stated · intraperitoneal · four weeksAs given in this study (rats).
Source sentences
Summary
Current results showed that sleep deprivation impaired both short- and long- term memories (P < 0.05), and that chronic CBL administration prevented such impairment.
2 context sentences(design, population, supporting numbers)
Summary · context
Sleep deprivation was induced in rats using the modified multiple platform model (8 h/day for 4 weeks).
Summary · context
Concurrently, CBL was administered intraperitoneally for four weeks.
Report a problemFND-3198789401
02AnimalAnimal study (in vivo)Efficacy outcome
In sleep-deprived rats, Cerebrolysin prevented long-term memory impairment compared with sleep deprivation without Cerebrolysin.
In plain wordsIn sleep-deprived rats, Cerebrolysin prevented long-term memory impairment compared with sleep deprivation without Cerebrolysin.
Peptide
Cerebrolysin
Outcome
IncreaseLong-term memory
Study
ratsn: not reported in source
Sleep deprivation by modified multiple platform model
Comparator
Sleep deprivation without Cerebrolysin
Outcome group
Cognition and memory · Nervous system and cognition
Studied dose
Dose not stated · intraperitoneal · four weeksAs given in this study (rats).
Source sentences
Summary
Current results showed that sleep deprivation impaired both short- and long- term memories (P < 0.05), and that chronic CBL administration prevented such impairment.
2 context sentences(design, population, supporting numbers)
Summary · context
Sleep deprivation was induced in rats using the modified multiple platform model (8 h/day for 4 weeks).
Summary · context
Concurrently, CBL was administered intraperitoneally for four weeks.
Report a problemFND-3198789402
03AnimalAnimal study (in vivo)Mechanism
In sleep-deprived rats, Cerebrolysin prevented the decrease in hippocampal GPx compared with sleep deprivation without Cerebrolysin.
In plain wordsIn sleep-deprived rats, Cerebrolysin prevented lower hippocampal GPx compared with sleep deprivation without Cerebrolysin.
Peptide
Cerebrolysin
Outcome
IncreaseHippocampal GPx
Study
ratsn: not reported in source
Sleep deprivation by modified multiple platform model
Comparator
Sleep deprivation without Cerebrolysin
Outcome group
Oxidative stress · Nervous system and cognition
Studied dose
Dose not stated · intraperitoneal · four weeksAs given in this study (rats).
Source sentences
Summary
Additionally, CBL prevented decreases in hippocampal GPx, catalase, GSH and GSH/GSSG ratio and normalized increases in GSSG levels, which were impaired by the sleep deprivation model (P < 0.05).
2 context sentences(design, population, supporting numbers)
Summary · context
Sleep deprivation was induced in rats using the modified multiple platform model (8 h/day for 4 weeks).
Summary · context
Concurrently, CBL was administered intraperitoneally for four weeks.
Report a problemFND-3198789403
04AnimalAnimal study (in vivo)Mechanism
In sleep-deprived rats, Cerebrolysin prevented the decrease in hippocampal catalase compared with sleep deprivation without Cerebrolysin.
In plain wordsIn sleep-deprived rats, Cerebrolysin prevented lower hippocampal catalase compared with sleep deprivation without Cerebrolysin.
Peptide
Cerebrolysin
Outcome
IncreaseHippocampal catalase
Study
ratsn: not reported in source
Sleep deprivation by modified multiple platform model
Comparator
Sleep deprivation without Cerebrolysin
Outcome group
Oxidative stress · Nervous system and cognition
Studied dose
Dose not stated · intraperitoneal · four weeksAs given in this study (rats).
Source sentences
Summary
Additionally, CBL prevented decreases in hippocampal GPx, catalase, GSH and GSH/GSSG ratio and normalized increases in GSSG levels, which were impaired by the sleep deprivation model (P < 0.05).
2 context sentences(design, population, supporting numbers)
Summary · context
Sleep deprivation was induced in rats using the modified multiple platform model (8 h/day for 4 weeks).
Summary · context
Concurrently, CBL was administered intraperitoneally for four weeks.
Report a problemFND-3198789404
05AnimalAnimal study (in vivo)Mechanism
In sleep-deprived rats, Cerebrolysin prevented the decrease in hippocampal GSH compared with sleep deprivation without Cerebrolysin.
In plain wordsIn sleep-deprived rats, Cerebrolysin prevented lower hippocampal GSH compared with sleep deprivation without Cerebrolysin.
Peptide
Cerebrolysin
Outcome
IncreaseHippocampal GSH
Study
ratsn: not reported in source
Sleep deprivation by modified multiple platform model
Comparator
Sleep deprivation without Cerebrolysin
Outcome group
Oxidative stress · Nervous system and cognition
Studied dose
Dose not stated · intraperitoneal · four weeksAs given in this study (rats).
Source sentences
Summary
Additionally, CBL prevented decreases in hippocampal GPx, catalase, GSH and GSH/GSSG ratio and normalized increases in GSSG levels, which were impaired by the sleep deprivation model (P < 0.05).
2 context sentences(design, population, supporting numbers)
Summary · context
Sleep deprivation was induced in rats using the modified multiple platform model (8 h/day for 4 weeks).
Summary · context
Concurrently, CBL was administered intraperitoneally for four weeks.
Report a problemFND-3198789405
06AnimalAnimal study (in vivo)Mechanism
In sleep-deprived rats, Cerebrolysin prevented the decrease in hippocampal GSH/GSSG ratio compared with sleep deprivation without Cerebrolysin.
In plain wordsIn sleep-deprived rats, Cerebrolysin prevented a lower hippocampal GSH/GSSG ratio compared with sleep deprivation without Cerebrolysin.
Peptide
Cerebrolysin
Outcome
IncreaseHippocampal GSH/GSSG ratio
Study
ratsn: not reported in source
Sleep deprivation by modified multiple platform model
Comparator
Sleep deprivation without Cerebrolysin
Outcome group
Oxidative stress · Nervous system and cognition
Studied dose
Dose not stated · intraperitoneal · four weeksAs given in this study (rats).
Source sentences
Summary
Additionally, CBL prevented decreases in hippocampal GPx, catalase, GSH and GSH/GSSG ratio and normalized increases in GSSG levels, which were impaired by the sleep deprivation model (P < 0.05).
2 context sentences(design, population, supporting numbers)
Summary · context
Sleep deprivation was induced in rats using the modified multiple platform model (8 h/day for 4 weeks).
Summary · context
Concurrently, CBL was administered intraperitoneally for four weeks.
Report a problemFND-3198789406
07AnimalAnimal study (in vivo)Mechanism
In sleep-deprived rats, Cerebrolysin normalized elevated hippocampal GSSG compared with sleep deprivation without Cerebrolysin.
In plain wordsIn sleep-deprived rats, Cerebrolysin normalized elevated hippocampal GSSG compared with sleep deprivation without Cerebrolysin.
Peptide
Cerebrolysin
Outcome
DecreaseHippocampal GSSG
Study
ratsn: not reported in source
Sleep deprivation by modified multiple platform model
Comparator
Sleep deprivation without Cerebrolysin
Outcome group
Oxidative stress · Nervous system and cognition
Studied dose
Dose not stated · intraperitoneal · four weeksAs given in this study (rats).
Source sentences
Summary
Additionally, CBL prevented decreases in hippocampal GPx, catalase, GSH and GSH/GSSG ratio and normalized increases in GSSG levels, which were impaired by the sleep deprivation model (P < 0.05).
2 context sentences(design, population, supporting numbers)
Summary · context
Sleep deprivation was induced in rats using the modified multiple platform model (8 h/day for 4 weeks).
Summary · context
Concurrently, CBL was administered intraperitoneally for four weeks.
Report a problemFND-3198789407

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
14 Oct 2026, 05:02 UTC
Study results updated
Version 1
14 Oct 2026, 01:46 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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