In obesity-prone rats, melanotan II injected into the hypothalamic paraventricular nucleus increased lumbar sympathetic nerve activity; it did not do so in obesity-resistant or control rats.
In plain wordsIn obesity-prone rats, melanotan II injected into a brain region raised sympathetic nerve activity. Obesity-resistant and control rats did not show this rise.
- Peptide
- Melanotan II
- Outcome
- IncreaseLumbar sympathetic nerve activity after PVN melanotan II
- Study
ratn: not reported in source
Sprague-Dawley rats fed a high-fat diet- Comparator
- Obesity-resistant and control-diet rats
- Outcome group
- Receptor activity and mechanism · Cardiovascular
- Studied dose
- Dose not stated · nanoinjection into the paraventricular nucleusAs given in this study (rat).
Source sentences
nanoinjection of the MC3/4R agonist melanotan II (MTII) into the PVN increased LSNA only in OP rats
1 context sentence(design, population, supporting numbers)
We studied conscious and α-chloralose-anesthetized Sprague-Dawley rats fed a high-fat diet, which causes obesity prone (OP) rats to accrue excess fat and obesity-resistant (OR) rats to maintain fat content, similar to rats fed a standard control (CON) diet.