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Study · Randomized controlled trial · 2020

4 results

Oxytocin effects on the resting-state mentalizing brain network.

Wu H, Feng C, Lu X, Liu X, Liu Q

Brain imaging and behavior1 Dec 2020Cited by 17 (Europe PMC)

PMID31955321 (opens in a new tab)DOI10.1007/s11682-019-00205-5 (opens in a new tab)PepBankPUB-31955321
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. 4 results from people.

  1. 01HumanRandomized controlled trialMechanism

    In a randomized placebo-controlled resting-state fMRI study, intranasal oxytocin increased functional connectivity between the right temporoparietal junction and the default attention network.

    In plain wordsIn a brain imaging trial, oxytocin raised connectivity between a brain region for understanding others and an attention network, compared with placebo.

    Peptide
    Oxytocin
    Outcome
    IncreaseFunctional connectivity between right TPJ and default attention network
    Study

    n: not reported in source

    Comparator
    Placebo
    Outcome group
    Brain and neuronal activity · Nervous system and cognition
    Studied dose
    Dose not stated · intranasalAs given in this study (human).

    Source sentences

    Summary
    OT significantly increased connectivity between rTPJ and default attention network (DAN)
    1 context sentence
    Summary · context
    Using a randomized, double-blind placebo-controlled group design, we investigate the resting-state functional magnetic resonance imaging after intranasal OT or placebo.
  2. 02HumanRandomized controlled trialMechanism

    In a randomized placebo-controlled resting-state fMRI study, intranasal oxytocin decreased functional connectivity between the left temporoparietal junction and the medial prefrontal network.

    In plain wordsIn a brain imaging trial, oxytocin lowered connectivity between two brain networks involved in understanding others, compared with placebo.

    Peptide
    Oxytocin
    Outcome
    DecreaseFunctional connectivity between left TPJ and medial prefrontal network
    Study

    n: not reported in source

    Comparator
    Placebo
    Outcome group
    Brain and neuronal activity · Nervous system and cognition
    Studied dose
    Dose not stated · intranasalAs given in this study (human).

    Source sentences

    Summary
    but decreased the FC between lTPJ and medial prefrontal network (MPN)
    1 context sentence
    Summary · context
    Using a randomized, double-blind placebo-controlled group design, we investigate the resting-state functional magnetic resonance imaging after intranasal OT or placebo.
  3. 03HumanRandomized controlled trialMechanism

    In a randomized placebo-controlled study, machine learning on altered temporoparietal junction connectivity could classify the oxytocin and placebo groups.

    In plain wordsIn a brain imaging trial, a computer model could tell the oxytocin group from the placebo group using brain connectivity patterns.

    Peptide
    Oxytocin
    Outcome
    Not applicableClassification of oxytocin versus placebo group from TPJ connectivity
    Study

    n: not reported in source

    Comparator
    Placebo
    Outcome group
    Brain and neuronal activity · Nervous system and cognition
    Studied dose
    Dose not stated · intranasalAs given in this study (human).

    Source sentences

    Summary
    With machine learning approach, we report that identified altered FCs of TPJ can classify OT and placebo (PL) group.
    1 context sentence
    Summary · context
    Using a randomized, double-blind placebo-controlled group design, we investigate the resting-state functional magnetic resonance imaging after intranasal OT or placebo.
  4. 04HumanRandomized controlled trialMechanism

    Connectivity between the left temporoparietal junction and the right rectus correlated positively with empathic concern in the placebo group but negatively in the oxytocin group.

    In plain wordsIn a brain imaging trial, the link between brain connectivity and empathy was positive with placebo but negative with oxytocin.

    Peptide
    Oxytocin
    Outcome
    MixedCorrelation of left TPJ-right rectus connectivity with empathic concern
    Study

    n: not reported in source

    Comparator
    Placebo
    Outcome group
    Brain and neuronal activity · Nervous system and cognition
    Studied dose
    Dose not stated · intranasalAs given in this study (human).

    Source sentences

    Summary
    Moreover, individual's empathy trait can modulate the FC between left TPJ and right rectus (RECT), which shows a positive correlation with empathic concern in PL group but a negative correlation in OT group.
    1 context sentence
    Summary · context
    Using a randomized, double-blind placebo-controlled group design, we investigate the resting-state functional magnetic resonance imaging after intranasal OT or placebo.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 00:50 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:49 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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