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Study · Animal study (in vivo) · mouse · 2020

17 results

Protective effect of MOTS-c on acute lung injury induced by lipopolysaccharide in mice.

Xinqiang Y, Quan C, Yuanyuan J, Hanmei X

International immunopharmacology10 Jan 2020Cited by 37 (Europe PMC)

PMID31931370 (opens in a new tab)DOI10.1016/j.intimp.2019.106174 (opens in a new tab)PepBankPUB-31931370
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study17

17 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In mice with LPS-induced acute lung injury, MOTS‑c pretreatment attenuated body weight loss.

    In plain wordsIn mice with lung injury, MOTS‑c given beforehand reduced body weight loss.

    Peptide
    MOTS-c
    Outcome
    DecreaseBody weight loss
    Study

    mousen: not reported in source

    Intratracheal LPS-induced acute lung injury
    Outcome group
    Body weight · Whole body
    Studied dose
    5 mg/kg twice daily · intraperitoneal · 6 daysAs given in this study (mouse).

    Source sentences

    Summary
    attenuated body weight loss and pulmonary edema
    1 context sentence
    Summary · context
    Hence, we investigated the potential effectiveness and underlying mechanism of MOTS-c against LPS-induced ALI in mice.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In mice with LPS-induced acute lung injury, MOTS‑c pretreatment attenuated pulmonary edema.

    In plain wordsIn mice with lung injury, MOTS‑c given beforehand reduced fluid build-up in the lungs.

    Peptide
    MOTS-c
    Outcome
    DecreasePulmonary edema
    Study

    mousen: not reported in source

    Intratracheal LPS-induced acute lung injury
    Outcome group
    Inflammation markers · Respiratory
    Studied dose
    5 mg/kg twice daily · intraperitoneal · 6 daysAs given in this study (mouse).

    Source sentences

    Summary
    attenuated body weight loss and pulmonary edema
    1 context sentence
    Summary · context
    Hence, we investigated the potential effectiveness and underlying mechanism of MOTS-c against LPS-induced ALI in mice.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In mice with LPS-induced acute lung injury, MOTS‑c inhibited neutrophilic infiltration in lung tissue.

    In plain wordsIn mice with lung injury, MOTS‑c reduced the spread of white blood cells into lung tissue.

    Peptide
    MOTS-c
    Outcome
    DecreaseNeutrophil infiltration in lung tissue
    Study

    mousen: not reported in source

    Intratracheal LPS-induced acute lung injury
    Outcome group
    Inflammation markers · Respiratory
    Studied dose
    5 mg/kg twice daily · intraperitoneal · 6 daysAs given in this study (mouse).

    Source sentences

    Summary
    inhibited neutrophilic tissue infiltration
    1 context sentence
    Summary · context
    Hence, we investigated the potential effectiveness and underlying mechanism of MOTS-c against LPS-induced ALI in mice.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In mice with LPS-induced acute lung injury, MOTS‑c downregulated the expression of CINC-1 in lung tissue.

    In plain wordsIn mice with lung injury, MOTS‑c lowered the lung level of the inflammation signal CINC-1.

    Peptide
    MOTS-c
    Outcome
    DecreaseCINC-1 expression in lung tissue
    Study

    mousen: not reported in source

    Intratracheal LPS-induced acute lung injury
    Outcome group
    Inflammation markers · Respiratory
    Studied dose
    5 mg/kg twice daily · intraperitoneal · 6 daysAs given in this study (mouse).

    Source sentences

    Summary
    downregulated the expression of cytokine-induced neutrophil chemoattractant-1 (CINC-1) and intercellular cell adhesion molecule-1 (ICAM-1) in lung tissues
    1 context sentence
    Summary · context
    Hence, we investigated the potential effectiveness and underlying mechanism of MOTS-c against LPS-induced ALI in mice.
  5. 05AnimalAnimal study (in vivo)Efficacy outcome

    In mice with LPS-induced acute lung injury, MOTS‑c downregulated the expression of ICAM-1 in lung tissue.

    In plain wordsIn mice with lung injury, MOTS‑c lowered the lung level of the adhesion molecule ICAM-1.

    Peptide
    MOTS-c
    Outcome
    DecreaseICAM-1 expression in lung tissue
    Study

    mousen: not reported in source

    Intratracheal LPS-induced acute lung injury
    Outcome group
    Inflammation markers · Respiratory
    Studied dose
    5 mg/kg twice daily · intraperitoneal · 6 daysAs given in this study (mouse).

    Source sentences

    Summary
    downregulated the expression of cytokine-induced neutrophil chemoattractant-1 (CINC-1) and intercellular cell adhesion molecule-1 (ICAM-1) in lung tissues
    1 context sentence
    Summary · context
    Hence, we investigated the potential effectiveness and underlying mechanism of MOTS-c against LPS-induced ALI in mice.
  6. 06AnimalAnimal study (in vivo)Efficacy outcome

    In mice with LPS-induced acute lung injury, MOTS‑c decreased TNF-α levels.

    In plain wordsIn mice with lung injury, MOTS‑c lowered the inflammation signal TNF-α.

    Peptide
    MOTS-c
    Outcome
    DecreaseTNF-α level
    Study

    mousen: not reported in source

    Intratracheal LPS-induced acute lung injury
    Outcome group
    Inflammation markers · Respiratory
    Studied dose
    5 mg/kg twice daily · intraperitoneal · 6 daysAs given in this study (mouse).

    Source sentences

    Summary
    decreased the levels of TNF-α, IL-1β, and IL-6
    1 context sentence
    Summary · context
    Hence, we investigated the potential effectiveness and underlying mechanism of MOTS-c against LPS-induced ALI in mice.
  7. 07AnimalAnimal study (in vivo)Efficacy outcome

    In mice with LPS-induced acute lung injury, MOTS‑c decreased IL-1β levels.

    In plain wordsIn mice with lung injury, MOTS‑c lowered the inflammation signal IL-1β.

    Peptide
    MOTS-c
    Outcome
    DecreaseIL-1β level
    Study

    mousen: not reported in source

    Intratracheal LPS-induced acute lung injury
    Outcome group
    Inflammation markers · Respiratory
    Studied dose
    5 mg/kg twice daily · intraperitoneal · 6 daysAs given in this study (mouse).

    Source sentences

    Summary
    decreased the levels of TNF-α, IL-1β, and IL-6
    1 context sentence
    Summary · context
    Hence, we investigated the potential effectiveness and underlying mechanism of MOTS-c against LPS-induced ALI in mice.
  8. 08AnimalAnimal study (in vivo)Efficacy outcome

    In mice with LPS-induced acute lung injury, MOTS‑c decreased IL-6 levels.

    In plain wordsIn mice with lung injury, MOTS‑c lowered the inflammation signal IL-6.

    Peptide
    MOTS-c
    Outcome
    DecreaseIL-6 level
    Study

    mousen: not reported in source

    Intratracheal LPS-induced acute lung injury
    Outcome group
    Inflammation markers · Respiratory
    Studied dose
    5 mg/kg twice daily · intraperitoneal · 6 daysAs given in this study (mouse).

    Source sentences

    Summary
    decreased the levels of TNF-α, IL-1β, and IL-6
    1 context sentence
    Summary · context
    Hence, we investigated the potential effectiveness and underlying mechanism of MOTS-c against LPS-induced ALI in mice.
  9. 09AnimalAnimal study (in vivo)Efficacy outcome

    In mice with LPS-induced acute lung injury, MOTS‑c increased the expression of IL-10 in serum, lung tissue and bronchoalveolar lavage fluid.

    In plain wordsIn mice with lung injury, MOTS‑c raised the anti-inflammatory signal IL-10 in blood and lungs.

    Peptide
    MOTS-c
    Outcome
    IncreaseIL-10 expression
    Study

    mousen: not reported in source

    Intratracheal LPS-induced acute lung injury
    Outcome group
    Inflammation markers · Respiratory
    Studied dose
    5 mg/kg twice daily · intraperitoneal · 6 daysAs given in this study (mouse).

    Source sentences

    Summary
    increased the expression of IL-10 and SOD in serum, lung tissue, and bronchoalvelolar lavage fluid (BALF).
    1 context sentence
    Summary · context
    Hence, we investigated the potential effectiveness and underlying mechanism of MOTS-c against LPS-induced ALI in mice.
  10. 10AnimalAnimal study (in vivo)Efficacy outcome

    In mice with LPS-induced acute lung injury, MOTS‑c increased the expression of SOD in serum, lung tissue and bronchoalveolar lavage fluid.

    In plain wordsIn mice with lung injury, MOTS‑c raised the antioxidant enzyme SOD in blood and lungs.

    Peptide
    MOTS-c
    Outcome
    IncreaseSOD expression
    Study

    mousen: not reported in source

    Intratracheal LPS-induced acute lung injury
    Outcome group
    Inflammation markers · Respiratory
    Studied dose
    5 mg/kg twice daily · intraperitoneal · 6 daysAs given in this study (mouse).

    Source sentences

    Summary
    increased the expression of IL-10 and SOD in serum, lung tissue, and bronchoalvelolar lavage fluid (BALF).
    1 context sentence
    Summary · context
    Hence, we investigated the potential effectiveness and underlying mechanism of MOTS-c against LPS-induced ALI in mice.
  11. 11AnimalAnimal study (in vivo)Mechanism

    In mice with LPS-induced acute lung injury, MOTS‑c treatment significantly promoted p-AMPKα expression in lung tissue.

    In plain wordsIn mice with lung injury, MOTS‑c raised the active form of the enzyme AMPK in the lungs.

    Peptide
    MOTS-c
    Outcome
    Increasep-AMPKα expression in lung tissue
    Study

    mousen: not reported in source

    Intratracheal LPS-induced acute lung injury
    Outcome group
    Receptor activity and mechanism · Respiratory
    Studied dose
    5 mg/kg twice daily · intraperitoneal · 6 daysAs given in this study (mouse).

    Source sentences

    Summary
    Moreover, MOTS-c treatment significantly promoted p-AMPKα and SIRT1 expression and suppressed LPS-induced ERK, JNK, p38, p65, and STAT3 activation in the mouse lung tissues.
    1 context sentence
    Summary · context
    Hence, we investigated the potential effectiveness and underlying mechanism of MOTS-c against LPS-induced ALI in mice.
  12. 12AnimalAnimal study (in vivo)Mechanism

    In mice with LPS-induced acute lung injury, MOTS‑c treatment significantly promoted SIRT1 expression in lung tissue.

    In plain wordsIn mice with lung injury, MOTS‑c raised the amount of SIRT1 in the lungs.

    Peptide
    MOTS-c
    Outcome
    IncreaseSIRT1 expression in lung tissue
    Study

    mousen: not reported in source

    Intratracheal LPS-induced acute lung injury
    Outcome group
    Receptor activity and mechanism · Respiratory
    Studied dose
    5 mg/kg twice daily · intraperitoneal · 6 daysAs given in this study (mouse).

    Source sentences

    Summary
    Moreover, MOTS-c treatment significantly promoted p-AMPKα and SIRT1 expression and suppressed LPS-induced ERK, JNK, p38, p65, and STAT3 activation in the mouse lung tissues.
    1 context sentence
    Summary · context
    Hence, we investigated the potential effectiveness and underlying mechanism of MOTS-c against LPS-induced ALI in mice.
  13. 13AnimalAnimal study (in vivo)Mechanism

    In mice with LPS-induced acute lung injury, MOTS‑c suppressed LPS-induced ERK activation in lung tissue.

    In plain wordsIn mice with lung injury, MOTS‑c reduced the ERK signal switched on by LPS.

    Peptide
    MOTS-c
    Outcome
    DecreaseLPS-induced ERK activation
    Study

    mousen: not reported in source

    Intratracheal LPS-induced acute lung injury
    Outcome group
    Receptor activity and mechanism · Respiratory
    Studied dose
    5 mg/kg twice daily · intraperitoneal · 6 daysAs given in this study (mouse).

    Source sentences

    Summary
    Moreover, MOTS-c treatment significantly promoted p-AMPKα and SIRT1 expression and suppressed LPS-induced ERK, JNK, p38, p65, and STAT3 activation in the mouse lung tissues.
    1 context sentence
    Summary · context
    Hence, we investigated the potential effectiveness and underlying mechanism of MOTS-c against LPS-induced ALI in mice.
  14. 14AnimalAnimal study (in vivo)Mechanism

    In mice with LPS-induced acute lung injury, MOTS‑c suppressed LPS-induced JNK activation in lung tissue.

    In plain wordsIn mice with lung injury, MOTS‑c reduced the JNK signal switched on by LPS.

    Peptide
    MOTS-c
    Outcome
    DecreaseLPS-induced JNK activation
    Study

    mousen: not reported in source

    Intratracheal LPS-induced acute lung injury
    Outcome group
    Receptor activity and mechanism · Respiratory
    Studied dose
    5 mg/kg twice daily · intraperitoneal · 6 daysAs given in this study (mouse).

    Source sentences

    Summary
    Moreover, MOTS-c treatment significantly promoted p-AMPKα and SIRT1 expression and suppressed LPS-induced ERK, JNK, p38, p65, and STAT3 activation in the mouse lung tissues.
    1 context sentence
    Summary · context
    Hence, we investigated the potential effectiveness and underlying mechanism of MOTS-c against LPS-induced ALI in mice.
  15. 15AnimalAnimal study (in vivo)Mechanism

    In mice with LPS-induced acute lung injury, MOTS‑c suppressed LPS-induced p38 activation in lung tissue.

    In plain wordsIn mice with lung injury, MOTS‑c reduced the p38 signal switched on by LPS.

    Peptide
    MOTS-c
    Outcome
    DecreaseLPS-induced p38 activation
    Study

    mousen: not reported in source

    Intratracheal LPS-induced acute lung injury
    Outcome group
    Receptor activity and mechanism · Respiratory
    Studied dose
    5 mg/kg twice daily · intraperitoneal · 6 daysAs given in this study (mouse).

    Source sentences

    Summary
    Moreover, MOTS-c treatment significantly promoted p-AMPKα and SIRT1 expression and suppressed LPS-induced ERK, JNK, p38, p65, and STAT3 activation in the mouse lung tissues.
    1 context sentence
    Summary · context
    Hence, we investigated the potential effectiveness and underlying mechanism of MOTS-c against LPS-induced ALI in mice.
  16. 16AnimalAnimal study (in vivo)Mechanism

    In mice with LPS-induced acute lung injury, MOTS‑c suppressed LPS-induced p65 activation in lung tissue.

    In plain wordsIn mice with lung injury, MOTS‑c reduced the p65 signal switched on by LPS.

    Peptide
    MOTS-c
    Outcome
    DecreaseLPS-induced p65 activation
    Study

    mousen: not reported in source

    Intratracheal LPS-induced acute lung injury
    Outcome group
    Receptor activity and mechanism · Respiratory
    Studied dose
    5 mg/kg twice daily · intraperitoneal · 6 daysAs given in this study (mouse).

    Source sentences

    Summary
    Moreover, MOTS-c treatment significantly promoted p-AMPKα and SIRT1 expression and suppressed LPS-induced ERK, JNK, p38, p65, and STAT3 activation in the mouse lung tissues.
    1 context sentence
    Summary · context
    Hence, we investigated the potential effectiveness and underlying mechanism of MOTS-c against LPS-induced ALI in mice.
  17. 17AnimalAnimal study (in vivo)Mechanism

    In mice with LPS-induced acute lung injury, MOTS‑c suppressed LPS-induced STAT3 activation in lung tissue.

    In plain wordsIn mice with lung injury, MOTS‑c reduced the STAT3 signal switched on by LPS.

    Peptide
    MOTS-c
    Outcome
    DecreaseLPS-induced STAT3 activation
    Study

    mousen: not reported in source

    Intratracheal LPS-induced acute lung injury
    Outcome group
    Receptor activity and mechanism · Respiratory
    Studied dose
    5 mg/kg twice daily · intraperitoneal · 6 daysAs given in this study (mouse).

    Source sentences

    Summary
    Moreover, MOTS-c treatment significantly promoted p-AMPKα and SIRT1 expression and suppressed LPS-induced ERK, JNK, p38, p65, and STAT3 activation in the mouse lung tissues.
    1 context sentence
    Summary · context
    Hence, we investigated the potential effectiveness and underlying mechanism of MOTS-c against LPS-induced ALI in mice.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    9 Oct 2026, 18:17 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:47 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

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