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Study · Randomized controlled trial · n = 161 · 2020

2 results

The role of oxytocin on self-serving lying.

Sindermann C, Luo R, Becker B, Kendrick KM, Montag C

Brain and behavior13 Jan 2020Cited by 5 (Europe PMC)

PMID31930678 (opens in a new tab)PMCIDPMC7010580 (opens in a new tab)DOI10.1002/brb3.1518 (opens in a new tab)PepBankPUB-31930678
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Summary

IntroductionThe effects of intranasal administration of the neuropeptide oxytocin on social cognition and behavior are highly specific. Potentially situational and personal variables influence these effects. The aim of the present study was to investigate effects of oxytocin administration on self-serving lying, including situational effects.MethodsA total of 161 adult males participated in a randomized double-blind placebo-controlled between-subject intranasal oxytocin administration (24 international units) study. Self-serving lying was assessed using three subsequent rounds of the die-in-a-cup paradigm, in which different degrees of lying can be implemented by the participants that can be determined on group level.ResultsOxytocin administration seemed to promote self-serving lying, particularly in the third (last) round and only to a certain degree (not to the maximum possible).ConclusionsOur findings demonstrate that oxytocin administration can promote self-serving lying when given repeated opportunities to lie. Moreover, exploratory results presented in the Supplementary Material indicate that the sensitivity to the effects of intranasal oxytocin in this domain might be moderated by individual differences in the oxytocin receptor gene.
CC BYText from Europe PMC. Highlighted sentences are the source of results.

Results from this study2

2 results from studies that gave the peptide. 2 results from people.

  1. 01HumanRandomized controlled trialEfficacy outcome

    In adult men, exploratory results suggest that the sensitivity to intranasal oxytocin effects on lying might be moderated by individual differences in the oxytocin receptor gene.

    In plain wordsIn adult men, an exploratory analysis suggests that differences in the oxytocin receptor gene might change how oxytocin affects lying.

    Peptide
    Oxytocin
    Outcome
    Not applicableModeration of oxytocin effect on lying by oxytocin receptor gene
    Study

    n = 161

    Comparator
    Placebo
    Analysis
    Exploratory
    Outcome group
    Social behavior and cognition · Mental health and mood
    Studied dose
    24 international units · intranasalAs given in this study (human).

    Source sentences

    Summary
    Moreover, exploratory results presented in the Supplementary Material indicate that the sensitivity to the effects of intranasal oxytocin in this domain might be moderated by individual differences in the oxytocin receptor gene.
    1 context sentence
    Summary · context
    A total of 161 adult males participated in a randomized double-blind placebo-controlled between-subject intranasal oxytocin administration (24 international units) study.
  2. 02HumanRandomized controlled trialEfficacy outcome

    In adult men, intranasal oxytocin seemed to promote self-serving lying compared with placebo, particularly in the third round and not to the maximum possible degree.

    In plain wordsIn adult men, oxytocin seemed to increase lying for personal gain, compared with placebo, mostly in the last round.

    Peptide
    Oxytocin
    Outcome
    IncreaseSelf-serving lying in the die-in-a-cup paradigm
    Study

    n = 161

    Comparator
    Placebo
    Outcome group
    Social behavior and cognition · Mental health and mood
    Studied dose
    24 international units · intranasalAs given in this study (human).

    Source sentences

    Summary
    Oxytocin administration seemed to promote self-serving lying, particularly in the third (last) round and only to a certain degree (not to the maximum possible).
    1 context sentence
    Summary · context
    A total of 161 adult males participated in a randomized double-blind placebo-controlled between-subject intranasal oxytocin administration (24 international units) study.

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 00:50 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:48 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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