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Study · Randomized controlled trial · 2020

4 results

Opposing sex-dependent effects of oxytocin on the perception of gaze direction.

Shi Y, Liu J, Hu Z, Gao S

Psychopharmacology16 Dec 2019Cited by 9 (Europe PMC)

PMID31844937 (opens in a new tab)DOI10.1007/s00213-019-05423-9 (opens in a new tab)PepBankPUB-31844937
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. 4 results from people.

  1. 01HumanRandomized controlled trialEfficacy outcome

    In men, oxytocin tended to decrease the cone of direct gaze compared with placebo.

    In plain wordsIn men, oxytocin tended to narrow the range of gaze directions judged as direct, compared with placebo.

    Peptide
    Oxytocin
    Outcome
    DecreaseCone of direct gaze (CoDG) width in men
    Study

    n: not reported in source

    Comparator
    Placebo
    Outcome group
    Social behavior and cognition · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    OXT, as compared with placebo, tended to decrease the CoDG in men but increase it in women.
    1 context sentence
    Summary · context
    We used the cone of direct gaze (CoDG) task.
  2. 02HumanRandomized controlled trialEfficacy outcome

    In women, oxytocin tended to increase the cone of direct gaze compared with placebo.

    In plain wordsIn women, oxytocin tended to widen the range of gaze directions judged as direct, compared with placebo.

    Peptide
    Oxytocin
    Outcome
    IncreaseCone of direct gaze (CoDG) width in women
    Study

    n: not reported in source

    Comparator
    Placebo
    Outcome group
    Social behavior and cognition · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    OXT, as compared with placebo, tended to decrease the CoDG in men but increase it in women.
    1 context sentence
    Summary · context
    We used the cone of direct gaze (CoDG) task.
  3. 03HumanRandomized controlled trialEfficacy outcome

    The marginally wider cone of direct gaze in men than in women under placebo was abolished after oxytocin treatment.

    In plain wordsMen's wider gaze range compared with women under placebo disappeared after oxytocin.

    Peptide
    Oxytocin
    Outcome
    No significant changeSex difference in CoDG after oxytocin
    Study

    n: not reported in source

    Comparator
    Placebo
    Outcome group
    Social behavior and cognition · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The CoDG was marginally wider in men than in women in the placebo condition, and however, this difference was abolished following OXT treatment.
    1 context sentence
    Summary · context
    We used the cone of direct gaze (CoDG) task.
  4. 04HumanRandomized controlled trialEfficacy outcome

    Oxytocin effects on the cone of direct gaze did not interact significantly with facial expression.

    In plain wordsOxytocin's effect on gaze judgments did not differ significantly between angry, neutral and fearful faces.

    Peptide
    Oxytocin
    Outcome
    No significant changeTreatment by facial expression interaction on CoDG
    Study

    n: not reported in source

    Comparator
    Placebo
    Outcome group
    Social behavior and cognition · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    However, there was no significant interaction between treatment and facial expression.
    1 context sentence
    Summary · context
    We used the cone of direct gaze (CoDG) task.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 00:50 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:49 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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