Short communication: pharmacokinetics of oxytocin administered intranasally to beef cattle.

Wagner BK, Relling AE, Kieffer JD, Moraes LE, Parker AJ

Domestic animal endocrinology15 Aug 2019Cited by 6 (Europe PMC)

PMID31830691DOI10.1016/j.domaniend.2019.106387PepBankPUB-31830691

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Summary

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Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Pharmacokinetics
In beef steers, plasma oxytocin concentrations after intranasal oxytocin changed with time and differed by treatment, with no treatment by time interaction.
In plain wordsIn beef steers, blood oxytocin levels changed over time and differed between the three nasal doses.
Peptide
Oxytocin
Outcome
Not applicablePlasma oxytocin concentration over time and by treatment
Study
Bos taurus steersn = 5
Outcome group
Pharmacokinetics · Pharmacology
Studied dose
0.33, 0.66 and 1.32 IU/kg BW · intranasalAs given in this study (Bos taurus steers).
Source sentences
Summary
No treatment by time interaction was detected; however, there was an effect of time (P < 0.001) and treatment (P = 0.002) on oxytocin concentrations over time.
2 context sentences(design, population, supporting numbers)
Summary · context
Five, weaned Bos taurus steers were used in a 3 × 3 Latin square design.
Summary · context
Treatments included 1) 0.33 IU oxytocin/kg BW (A, n = 5), 2) 0.66 IU oxytocin/kg BW (B, n = 5), and 3) 1.32 IU oxytocin/kg BW (C, n = 5).
Report a problemFND-3183069101
02AnimalAnimal study (in vivo)Pharmacokinetics
In beef steers, intranasal oxytocin gave an average maximum plasma concentration of 63.3 pg/mL at 3.5 min.
In plain wordsIn beef steers, nasal oxytocin reached its highest blood level within a few minutes.
Peptide
Oxytocin
Outcome
Not applicableMaximum plasma concentration (Cmax)
Study
Bos taurus steersn = 5
Outcome group
Pharmacokinetics · Pharmacology
Studied dose
0.33, 0.66 and 1.32 IU/kg BW · intranasalAs given in this study (Bos taurus steers).
Measurements
Cmax
63.3 pg/mL
average, intranasal
Tmax
3.5 min
average, intranasal
Source sentences
Summary
Pharmacokinetic parameters, determined by PKSolver excel add-in, demonstrated an average maximum concentration (C_MAX) of 63.3 pg/mL at 3.5 min after intranasal dose administration.
2 context sentences(design, population, supporting numbers)
Summary · context
Five, weaned Bos taurus steers were used in a 3 × 3 Latin square design.
Summary · context
Treatments included 1) 0.33 IU oxytocin/kg BW (A, n = 5), 2) 0.66 IU oxytocin/kg BW (B, n = 5), and 3) 1.32 IU oxytocin/kg BW (C, n = 5).
Report a problemFND-3183069102
03AnimalAnimal study (in vivo)Pharmacokinetics
In beef steers, the average plasma half-life of intranasal oxytocin was 12.1 min.
In plain wordsIn beef steers, oxytocin given in the nose had a blood half-life of 12.1 minutes.
Peptide
Oxytocin
Outcome
Not applicableHalf-life
Study
Bos taurus steersn = 5
Outcome group
Pharmacokinetics · Pharmacology
Studied dose
0.33, 0.66 and 1.32 IU/kg BW · intranasalAs given in this study (Bos taurus steers).
Measurements
T1/2
12.1 min
average, intranasal
Source sentences
Summary
An average half-life (T_1/2) of 12.1 min after intranasal administration was determined.
2 context sentences(design, population, supporting numbers)
Summary · context
Five, weaned Bos taurus steers were used in a 3 × 3 Latin square design.
Summary · context
Treatments included 1) 0.33 IU oxytocin/kg BW (A, n = 5), 2) 0.66 IU oxytocin/kg BW (B, n = 5), and 3) 1.32 IU oxytocin/kg BW (C, n = 5).
Report a problemFND-3183069103
04AnimalAnimal study (in vivo)Pharmacokinetics
In beef steers, pharmacokinetic parameters after a single intranasal bolus were not dose-dependent.
In plain wordsIn beef steers, blood levels after a single nasal dose did not rise in step with the dose.
Peptide
Oxytocin
Outcome
No significant changeDose dependence of pharmacokinetic parameters
Study
Bos taurus steersn = 5
Outcome group
Pharmacokinetics · Pharmacology
Studied dose
0.33, 0.66 and 1.32 IU/kg BW · intranasalAs given in this study (Bos taurus steers).
Source sentences
Summary
Pharmacokinetic parameters to a single bolus were not dose-dependent.
2 context sentences(design, population, supporting numbers)
Summary · context
Five, weaned Bos taurus steers were used in a 3 × 3 Latin square design.
Summary · context
Treatments included 1) 0.33 IU oxytocin/kg BW (A, n = 5), 2) 0.66 IU oxytocin/kg BW (B, n = 5), and 3) 1.32 IU oxytocin/kg BW (C, n = 5).
Report a problemFND-3183069104

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
11 Oct 2026, 00:50 UTC
Study results updated
Version 1
9 Oct 2026, 02:48 UTC
First added · source update from Europe PMC

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