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Study · Randomized controlled trial · n = 144 · 2020

4 results

The influence of gender and oxytocin on stress reactivity, cigarette craving, and smoking in a randomized, placebo-controlled laboratory relapse paradigm.

McClure EA, Baker NL, Gray KM, Hood CO, Tomko RL, Carpenter MJ, Ramakrishnan VR, Buchanan CJ, Saladin ME

Psychopharmacology3 Dec 2019Cited by 24 (Europe PMC)

PMID31792646 (opens in a new tab)PMCIDPMC7024045 (opens in a new tab)DOI10.1007/s00213-019-05392-z (opens in a new tab)PepBankPUB-31792646
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. 4 results from people.

  1. 01HumanRandomized controlled trialEfficacy outcome

    In adult cigarette smokers, intranasal oxytocin did not attenuate stress reactivity compared with placebo.

    In plain wordsIn adult smokers, oxytocin did not reduce stress responses, compared with placebo.

    Peptide
    Oxytocin
    Outcome
    No significant changeStress reactivity
    Study

    n = 144

    Comparator
    Placebo
    Outcome group
    Anxiety and mood · Mental health and mood
    Studied dose
    Dose not stated · intranasalAs given in this study (human).

    Source sentences

    Summary
    Oxytocin did not attenuate any aspect of stress reactivity, craving, smoking, or subjective responses to smoking compared with placebo.
    2 context sentences
    Summary · context
    Male and female adult cigarette smokers (ages 18-45) were enrolled (women oversampled 2:1) and completed a laboratory session, in which intranasal oxytocin or placebo was administered followed by a laboratory social stress task.
    Summary · context
    Participants (N = 144) had a mean age of 31 were 63% female and 56% White.
  2. 02HumanRandomized controlled trialEfficacy outcome

    In adult cigarette smokers, intranasal oxytocin did not attenuate cigarette craving compared with placebo.

    In plain wordsIn adult smokers, oxytocin did not reduce cigarette craving, compared with placebo.

    Peptide
    Oxytocin
    Outcome
    No significant changeCigarette craving
    Study

    n = 144

    Comparator
    Placebo
    Outcome group
    Addiction, withdrawal and alcohol intake · Mental health and mood
    Studied dose
    Dose not stated · intranasalAs given in this study (human).

    Source sentences

    Summary
    Oxytocin did not attenuate any aspect of stress reactivity, craving, smoking, or subjective responses to smoking compared with placebo.
    2 context sentences
    Summary · context
    Male and female adult cigarette smokers (ages 18-45) were enrolled (women oversampled 2:1) and completed a laboratory session, in which intranasal oxytocin or placebo was administered followed by a laboratory social stress task.
    Summary · context
    Participants (N = 144) had a mean age of 31 were 63% female and 56% White.
  3. 03HumanRandomized controlled trialEfficacy outcome

    In adult cigarette smokers, intranasal oxytocin did not attenuate smoking in the laboratory relapse paradigm compared with placebo.

    In plain wordsIn adult smokers, oxytocin did not reduce smoking in a lab test, compared with placebo.

    Peptide
    Oxytocin
    Outcome
    No significant changeSmoking behavior in laboratory relapse paradigm
    Study

    n = 144

    Comparator
    Placebo
    Outcome group
    Addiction, withdrawal and alcohol intake · Mental health and mood
    Studied dose
    Dose not stated · intranasalAs given in this study (human).

    Source sentences

    Summary
    Oxytocin did not attenuate any aspect of stress reactivity, craving, smoking, or subjective responses to smoking compared with placebo.
    2 context sentences
    Summary · context
    Male and female adult cigarette smokers (ages 18-45) were enrolled (women oversampled 2:1) and completed a laboratory session, in which intranasal oxytocin or placebo was administered followed by a laboratory social stress task.
    Summary · context
    Participants (N = 144) had a mean age of 31 were 63% female and 56% White.
  4. 04HumanRandomized controlled trialEfficacy outcome

    In adult cigarette smokers, intranasal oxytocin did not change subjective responses to smoking compared with placebo.

    In plain wordsIn adult smokers, oxytocin did not change how smoking felt, compared with placebo.

    Peptide
    Oxytocin
    Outcome
    No significant changeSubjective responses to smoking
    Study

    n = 144

    Comparator
    Placebo
    Outcome group
    Addiction, withdrawal and alcohol intake · Mental health and mood
    Studied dose
    Dose not stated · intranasalAs given in this study (human).

    Source sentences

    Summary
    Oxytocin did not attenuate any aspect of stress reactivity, craving, smoking, or subjective responses to smoking compared with placebo.
    2 context sentences
    Summary · context
    Male and female adult cigarette smokers (ages 18-45) were enrolled (women oversampled 2:1) and completed a laboratory session, in which intranasal oxytocin or placebo was administered followed by a laboratory social stress task.
    Summary · context
    Participants (N = 144) had a mean age of 31 were 63% female and 56% White.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 00:50 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:48 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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