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Study · Not a test of the peptide alone · 2020

2 results

Effect of oligoarginine conjugation on the antiwrinkle activity and transdermal delivery of GHK peptide.

Hur GH, Han SC, Ryu AR, Eom Y, Kim JW, Lee MY

Journal of peptide science : an official publication of the European Peptide Society1 Dec 2019Cited by 9 (Europe PMC)

PMID31788907 (opens in a new tab)DOI10.1002/psc.3234 (opens in a new tab)PepBankPUB-31788907
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone2

In this study, GHK-Cu was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking GHK-Cu.

  1. 01AnimalNot a test of GHK-Cu aloneAnimal study (in vivo)Other

    Arg4 conjugation accelerated the cellular penetration of GHK in vivo.

    In plain wordsIn animal tests, attaching Arg4 to GHK helped the peptide enter cells faster.

    Peptide
    GHK-Cu
    Outcome
    IncreaseCellular penetration of GHK with Arg4 conjugation, in vivo
    Study

    n: not reported in source

    In vivo
    Comparator
    GHK without Arg4 conjugation
    Outcome group
    Formulation, delivery and stability · Skin and wound

    Source sentences

    Summary
    Notably, Arg4 conjugation accelerated the cellular penetration of GHK both in vitro and in vivo.
    1 context sentence
    Summary · context
    In this investigation, Arg4 was conjugated with GHK to get heptapeptide, GHK-R4, and then in vitro antiwrinkle activity and transdermal delivery were compared between GHK and GHK-R4.

    In this study, GHK-Cu was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHK-Cu.

  2. 02LabNot a test of GHK-Cu aloneIn vitro (cells)Other

    Arg4 conjugation accelerated the cellular penetration of GHK in vitro.

    In plain wordsIn lab tests, attaching Arg4 to GHK helped the peptide enter cells faster.

    Peptide
    GHK-Cu
    Outcome
    IncreaseCellular penetration of GHK with Arg4 conjugation, in vitro
    Study

    n: not reported in source

    In vitro cells
    Comparator
    GHK without Arg4 conjugation
    Outcome group
    Formulation, delivery and stability · Skin and wound

    Source sentences

    Summary
    Notably, Arg4 conjugation accelerated the cellular penetration of GHK both in vitro and in vivo.
    1 context sentence
    Summary · context
    In this investigation, Arg4 was conjugated with GHK to get heptapeptide, GHK-R4, and then in vitro antiwrinkle activity and transdermal delivery were compared between GHK and GHK-R4.

    In this study, GHK-Cu was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHK-Cu.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    9 Oct 2026, 18:17 UTC

    Study results updated

  2. Version 2

    9 Oct 2026, 03:03 UTC

    Study data updated · source update from Europe PMC

  3. Version 1

    9 Oct 2026, 02:56 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

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