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Study · Randomized controlled trial · n = 90 · 2020

6 results

Kinetics of oxytocin effects on amygdala and striatal reactivity vary between women and men.

Lieberz J, Scheele D, Spengler FB, Matheisen T, Schneider L, Stoffel-Wagner B, Kinfe TM, Hurlemann R

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology30 Nov 2019Cited by 82 (Europe PMC)

PMID31785587 (opens in a new tab)PMCIDPMC7235226 (opens in a new tab)DOI10.1038/s41386-019-0582-6 (opens in a new tab)PepBankPUB-31785587
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

6 results from studies that gave the peptide. 6 results from people.

  1. 01HumanRandomized controlled trialMechanism

    In healthy women, oxytocin across doses enhanced amygdala reactivity to faces with low fear intensity, compared with placebo.

    In plain wordsIn healthy women, oxytocin increased the brain's amygdala response to mildly fearful faces, compared with placebo.

    Peptide
    Oxytocin
    Outcome
    IncreaseAmygdala reactivity to low fearful faces
    Study

    n = 90

    Comparator
    Placebo
    Outcome group
    Anxiety and mood · Nervous system and cognition
    Studied dose
    6 IU, 12 IU and 24 IUAs given in this study (human).

    Source sentences

    Summary
    Across doses, OXT enhanced amygdala reactivity to low fearful faces compared to placebo
    2 context sentences
    Summary · context
    To address this question, a total of 90 healthy women participated in a double-blind, placebo-controlled crossover functional magnetic resonance imaging (fMRI) study and the results were compared with our previous findings from men.
    Summary · context
    Participants were randomly assigned to three doses of OXT (6 IU, 12 IU, and 24 IU) and completed an emotional face recognition task including fearful and happy faces of varying emotional intensities.
  2. 02HumanRandomized controlled trialMechanism

    In healthy women, oxytocin across doses increased dorsal striatum responses to happy faces, compared with placebo.

    In plain wordsIn healthy women, oxytocin increased the brain's striatum response to happy faces, compared with placebo.

    Peptide
    Oxytocin
    Outcome
    IncreaseDorsal striatum response to happy faces
    Study

    n = 90

    Comparator
    Placebo
    Outcome group
    Brain and neuronal activity · Nervous system and cognition
    Studied dose
    6 IU, 12 IU and 24 IUAs given in this study (human).

    Source sentences

    Summary
    increased responses to happy faces in the dorsal striatum in women.
    2 context sentences
    Summary · context
    To address this question, a total of 90 healthy women participated in a double-blind, placebo-controlled crossover functional magnetic resonance imaging (fMRI) study and the results were compared with our previous findings from men.
    Summary · context
    Participants were randomly assigned to three doses of OXT (6 IU, 12 IU, and 24 IU) and completed an emotional face recognition task including fearful and happy faces of varying emotional intensities.
  3. 03HumanRandomized controlled trialMechanism

    In healthy women, the oxytocin effect on amygdala reactivity was present at each dose tested.

    In plain wordsIn healthy women, oxytocin raised the amygdala response at every dose tested, compared with placebo.

    Peptide
    Oxytocin
    Outcome
    IncreaseAmygdala reactivity effect at each dose
    Study

    n: not reported in source

    Comparator
    Placebo
    Outcome group
    Brain and neuronal activity · Nervous system and cognition
    Studied dose
    6 IU, 12 IU and 24 IUAs given in this study (human).

    Source sentences

    Summary
    While treatment effects on amygdala reactivity were evident at each given dose, the OXT effect on striatal responses to social stimuli was more pronounced with higher doses, but this dose-dependent effect did not survive correction for multiple comparisons.
    2 context sentences
    Summary · context
    To address this question, a total of 90 healthy women participated in a double-blind, placebo-controlled crossover functional magnetic resonance imaging (fMRI) study and the results were compared with our previous findings from men.
    Summary · context
    Participants were randomly assigned to three doses of OXT (6 IU, 12 IU, and 24 IU) and completed an emotional face recognition task including fearful and happy faces of varying emotional intensities.
  4. 04HumanRandomized controlled trialMechanism

    In healthy women, the larger striatal response at higher oxytocin doses did not survive correction for multiple comparisons.

    In plain wordsIn healthy women, a stronger striatum response at higher oxytocin doses was not confirmed after statistical correction.

    Peptide
    Oxytocin
    Outcome
    No significant changeDose dependence of striatal response to social stimuli
    Study

    n: not reported in source

    Comparator
    Placebo
    Outcome group
    Brain and neuronal activity · Nervous system and cognition
    Studied dose
    6 IU, 12 IU and 24 IUAs given in this study (human).

    Source sentences

    Summary
    the OXT effect on striatal responses to social stimuli was more pronounced with higher doses, but this dose-dependent effect did not survive correction for multiple comparisons.
    2 context sentences
    Summary · context
    To address this question, a total of 90 healthy women participated in a double-blind, placebo-controlled crossover functional magnetic resonance imaging (fMRI) study and the results were compared with our previous findings from men.
    Summary · context
    Participants were randomly assigned to three doses of OXT (6 IU, 12 IU, and 24 IU) and completed an emotional face recognition task including fearful and happy faces of varying emotional intensities.
  5. 05HumanRandomized controlled trialMechanism

    Oxytocin effects on amygdala and striatal activation differed significantly between women and men.

    In plain wordsOxytocin changed amygdala and striatum activity differently in women than in men from an earlier study.

    Peptide
    Oxytocin
    Outcome
    MixedSex difference in oxytocin effects on amygdala and striatal activation
    Study

    n: not reported in source

    Comparator
    Men (previous study)
    Outcome group
    Brain and neuronal activity · Nervous system and cognition
    Studied dose
    6 IU, 12 IU and 24 IUAs given in this study (human).

    Source sentences

    Summary
    OXT effects on amygdala and striatal activation significantly differed between sexes and striatal baseline sexual-dimorphic response patterns were diminished after administration of OXT.
    2 context sentences
    Summary · context
    To address this question, a total of 90 healthy women participated in a double-blind, placebo-controlled crossover functional magnetic resonance imaging (fMRI) study and the results were compared with our previous findings from men.
    Summary · context
    Participants were randomly assigned to three doses of OXT (6 IU, 12 IU, and 24 IU) and completed an emotional face recognition task including fearful and happy faces of varying emotional intensities.
  6. 06HumanRandomized controlled trialMechanism

    Oxytocin diminished the baseline sex-dimorphic striatal response patterns.

    In plain wordsOxytocin reduced the usual sex differences in how the striatum responds.

    Peptide
    Oxytocin
    Outcome
    DecreaseSex-dimorphic baseline striatal response pattern after oxytocin
    Study

    n: not reported in source

    Outcome group
    Brain and neuronal activity · Nervous system and cognition
    Studied dose
    6 IU, 12 IU and 24 IUAs given in this study (human).

    Source sentences

    Summary
    striatal baseline sexual-dimorphic response patterns were diminished after administration of OXT.
    2 context sentences
    Summary · context
    To address this question, a total of 90 healthy women participated in a double-blind, placebo-controlled crossover functional magnetic resonance imaging (fMRI) study and the results were compared with our previous findings from men.
    Summary · context
    Participants were randomly assigned to three doses of OXT (6 IU, 12 IU, and 24 IU) and completed an emotional face recognition task including fearful and happy faces of varying emotional intensities.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 00:50 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:49 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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