Skip to content

Study · Animal study (in vivo) · mouse · 2019

4 results

Neuroprotective Dipeptide Noopept Prevents DNA Damage in Mice with Modeled Prediabetes.

Ostrovskaya RU, Yagubova SS, Zhanataev AK, Anisina EA, Gudasheva TA, Durnev AD

Bulletin of experimental biology and medicine27 Nov 2019Cited by 1 (Europe PMC)

PMID31776952 (opens in a new tab)DOI10.1007/s10517-019-04681-z (opens in a new tab)PepBankPUB-31776952
Publisher pagePubMedAsk about this study
Jump to 4 results

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In prediabetic mice, Noopept normalized pancreatic DNA damage.

    In plain wordsIn mice with modeled prediabetes, Noopept normalized pancreatic DNA damage.

    Peptide
    Noopept (omberacetam)
    Outcome
    DecreasePancreatic DNA damage
    Study

    mousen: not reported in source

    BALB/c mice with modeled prediabetes
    Outcome group
    Genome stability · Endocrine and hormones
    Studied dose
    0.5 mg/kg · intraperitoneal · 14 days before and 6, 13, or 14 days after streptozotocinAs given in this study (mouse).

    Source sentences

    Summary
    Noopept normalized these parameters due to its pronounced antigenotoxic effect.
    3 context sentences
    Summary · context
    Despite moderate hyperglycemia and increased malondialdehyde level, the intensity of DNA damage in cells of the pancreas, liver, and kidneys significantly surpassed the control values.
    Summary · context
    In experiments on BALB/c mice, prediabetes was modeled by administration of streptozotocin in a dose of 130 mg/kg.
    Summary · context
    Noopept (0.5 mg/kg intraperitoneally) was administered for 14 days before and for 6, 13, or 14 days after streptozotocin administration.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In prediabetic mice, Noopept normalized liver DNA damage.

    In plain wordsIn mice with modeled prediabetes, Noopept normalized liver DNA damage.

    Peptide
    Noopept (omberacetam)
    Outcome
    DecreaseLiver DNA damage
    Study

    mousen: not reported in source

    BALB/c mice with modeled prediabetes
    Outcome group
    Genome stability · Liver
    Studied dose
    0.5 mg/kg · intraperitoneal · 14 days before and 6, 13, or 14 days after streptozotocinAs given in this study (mouse).

    Source sentences

    Summary
    Noopept normalized these parameters due to its pronounced antigenotoxic effect.
    3 context sentences
    Summary · context
    Despite moderate hyperglycemia and increased malondialdehyde level, the intensity of DNA damage in cells of the pancreas, liver, and kidneys significantly surpassed the control values.
    Summary · context
    In experiments on BALB/c mice, prediabetes was modeled by administration of streptozotocin in a dose of 130 mg/kg.
    Summary · context
    Noopept (0.5 mg/kg intraperitoneally) was administered for 14 days before and for 6, 13, or 14 days after streptozotocin administration.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In prediabetic mice, Noopept normalized kidney DNA damage.

    In plain wordsIn mice with modeled prediabetes, Noopept normalized kidney DNA damage.

    Peptide
    Noopept (omberacetam)
    Outcome
    DecreaseKidney DNA damage
    Study

    mousen: not reported in source

    BALB/c mice with modeled prediabetes
    Outcome group
    Genome stability · Kidney and urinary
    Studied dose
    0.5 mg/kg · intraperitoneal · 14 days before and 6, 13, or 14 days after streptozotocinAs given in this study (mouse).

    Source sentences

    Summary
    Noopept normalized these parameters due to its pronounced antigenotoxic effect.
    3 context sentences
    Summary · context
    Despite moderate hyperglycemia and increased malondialdehyde level, the intensity of DNA damage in cells of the pancreas, liver, and kidneys significantly surpassed the control values.
    Summary · context
    In experiments on BALB/c mice, prediabetes was modeled by administration of streptozotocin in a dose of 130 mg/kg.
    Summary · context
    Noopept (0.5 mg/kg intraperitoneally) was administered for 14 days before and for 6, 13, or 14 days after streptozotocin administration.
  4. 04AnimalAnimal study (in vivo)Mechanism

    In prediabetic mice, Noopept-associated DNA normalization manifested mainly through atypical DNA comets.

    In plain wordsIn mice with modeled prediabetes, Noopept-associated DNA normalization mainly involved atypical DNA comets.

    Peptide
    Noopept (omberacetam)
    Outcome
    Not applicableAtypical DNA comets
    Study

    mousen: not reported in source

    BALB/c mice with modeled prediabetes
    Outcome group
    Genome stability · Whole body
    Studied dose
    0.5 mg/kg · intraperitoneal · 14 days before and 6, 13, or 14 days after streptozotocinAs given in this study (mouse).

    Source sentences

    Summary
    For both the damaging effect of streptozotocin and the normalizing effect of Noopept, DNA changes manifested mainly in terms of atypical DNA comets.
    2 context sentences
    Summary · context
    In experiments on BALB/c mice, prediabetes was modeled by administration of streptozotocin in a dose of 130 mg/kg.
    Summary · context
    Noopept (0.5 mg/kg intraperitoneally) was administered for 14 days before and for 6, 13, or 14 days after streptozotocin administration.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 12:50 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

PepBank is a research reference. Talk to a doctor before you use any peptide.