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Study · Animal study (in vivo) · 2020

6 results

Immunopotentiator thymosin alpha-1 attenuates inflammatory pain by modulating the Wnt3a/β-catenin pathway in spinal cord.

Huang J, Jiang H, Pan M, Jiang Y, Xie L

Neuroreport1 Jan 2020Cited by 3 (Europe PMC)

PMID31764244 (opens in a new tab)DOI10.1097/wnr.0000000000001370 (opens in a new tab)PepBankPUB-31764244
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

6 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In animals with CFA-induced inflammatory pain, thymosin alpha‑1 attenuated mechanical allodynia.

    In plain wordsIn animals with inflammatory pain, thymosin alpha‑1 reduced pain from light touch.

    Peptide
    Thymosin alpha-1
    Outcome
    DecreaseCFA-induced mechanical allodynia
    Study

    n: not reported in source

    CFA-induced inflammatory pain
    Outcome group
    Pain · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Tα1 can attenuate the complete Freund's adjuvant (CFA)-induced mechanical allodynia
    1 context sentence
    Summary · context
    In this study, we found Tα1 can attenuate the complete Freund's adjuvant (CFA)-induced mechanical allodynia and heat hyperalgesia.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In animals with CFA-induced inflammatory pain, thymosin alpha‑1 attenuated heat hyperalgesia.

    In plain wordsIn animals with inflammatory pain, thymosin alpha‑1 reduced heightened pain from heat.

    Peptide
    Thymosin alpha-1
    Outcome
    DecreaseCFA-induced heat hyperalgesia
    Study

    n: not reported in source

    CFA-induced inflammatory pain
    Outcome group
    Pain · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Tα1 can attenuate the complete Freund's adjuvant (CFA)-induced mechanical allodynia and heat hyperalgesia.
    1 context sentence
    Summary · context
    In this study, we found Tα1 can attenuate the complete Freund's adjuvant (CFA)-induced mechanical allodynia and heat hyperalgesia.
  3. 03AnimalAnimal study (in vivo)Mechanism

    In animals with CFA-induced inflammatory pain, thymosin alpha‑1 reduced the upregulation of interferon-γ.

    In plain wordsIn animals with inflammatory pain, thymosin alpha‑1 lowered the rise in the inflammation signal interferon-γ.

    Peptide
    Thymosin alpha-1
    Outcome
    DecreaseInterferon-γ upregulation
    Study

    n: not reported in source

    CFA-induced inflammatory pain
    Outcome group
    Inflammation markers · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Meanwhile, it reduced the upregulation of CFA-induced inflammatory mediators (interferon (IFN)-γ, tumor necrosis factor-α and brain-derived neurotrophic factor).
    1 context sentence
    Summary · context
    In this study, we found Tα1 can attenuate the complete Freund's adjuvant (CFA)-induced mechanical allodynia and heat hyperalgesia.
  4. 04AnimalAnimal study (in vivo)Mechanism

    In animals with CFA-induced inflammatory pain, thymosin alpha‑1 reduced the upregulation of tumor necrosis factor-α.

    In plain wordsIn animals with inflammatory pain, thymosin alpha‑1 lowered the rise in the inflammation signal TNF-α.

    Peptide
    Thymosin alpha-1
    Outcome
    DecreaseTumor necrosis factor-α upregulation
    Study

    n: not reported in source

    CFA-induced inflammatory pain
    Outcome group
    Inflammation markers · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Meanwhile, it reduced the upregulation of CFA-induced inflammatory mediators (interferon (IFN)-γ, tumor necrosis factor-α and brain-derived neurotrophic factor).
    1 context sentence
    Summary · context
    In this study, we found Tα1 can attenuate the complete Freund's adjuvant (CFA)-induced mechanical allodynia and heat hyperalgesia.
  5. 05AnimalAnimal study (in vivo)Mechanism

    In animals with CFA-induced inflammatory pain, thymosin alpha‑1 reduced the upregulation of brain-derived neurotrophic factor.

    In plain wordsIn animals with inflammatory pain, thymosin alpha‑1 lowered the rise in the signal protein BDNF.

    Peptide
    Thymosin alpha-1
    Outcome
    DecreaseBrain-derived neurotrophic factor upregulation
    Study

    n: not reported in source

    CFA-induced inflammatory pain
    Outcome group
    Inflammation markers · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Meanwhile, it reduced the upregulation of CFA-induced inflammatory mediators (interferon (IFN)-γ, tumor necrosis factor-α and brain-derived neurotrophic factor).
    1 context sentence
    Summary · context
    In this study, we found Tα1 can attenuate the complete Freund's adjuvant (CFA)-induced mechanical allodynia and heat hyperalgesia.
  6. 06AnimalAnimal study (in vivo)Mechanism

    In animals with CFA-induced inflammatory pain, thymosin alpha‑1 reversed the CFA-induced activation of the Wnt3a/β-catenin pathway in the spinal cord.

    In plain wordsIn animals with inflammatory pain, thymosin alpha‑1 reversed the activation of a spinal cord pathway linked to pain.

    Peptide
    Thymosin alpha-1
    Outcome
    DecreaseWnt3a/β-catenin pathway activation in spinal cord
    Study

    n: not reported in source

    CFA-induced inflammatory pain
    Outcome group
    Pain · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In addition, we found the Wnt3a/β-catenin pathway was activated in spinal cord after the injection of CFA, paralleling with pain hypersensitivity. However, Tα1 reversed this status.
    1 context sentence
    Summary · context
    In this study, we found Tα1 can attenuate the complete Freund's adjuvant (CFA)-induced mechanical allodynia and heat hyperalgesia.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    10 Oct 2026, 08:55 UTC

    Study results updated

  2. Version 2

    9 Oct 2026, 03:03 UTC

    Study data updated · source update from Europe PMC

  3. Version 1

    9 Oct 2026, 03:02 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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