Effect of Peptide AEDG on Telomere Length and Mitotic Index of PHA-Stimulated Human Blood Lymphocytes.

Khavinson VK, Pendina AA, Efimova OA, Tikhonov AV, Koltsova AS, Krapivin MI, Petrovskaia-Kaminskaia AV, Petrova LI, Lin'kova NS, Baranov VS

Bulletin of experimental biology and medicine25 Nov 2019Cited by 6 (Europe PMC)

PMID31761987DOI10.1007/s10517-019-04664-0PepBankPUB-31761987

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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

6 results from studies that gave the peptide. No result from this study comes from people.

01LabEx vivo tissueEfficacy outcome
In PHA-stimulated blood lymphocytes from young and middle-aged men, incubation with AEDG significantly changed relative telomere length in 7 of 11 individuals.
In plain wordsIn lab-grown blood cells from 11 donors, the peptide AEDG changed telomere length in 7 of them, in different directions.
Peptide
Epitalon
Outcome
MixedRelative telomere length, any significant change
Study
humann = 11
PHA-stimulated blood lymphocytes
Outcome group
Aging markers · Aging and longevity
Studied dose
Dose not stated
Source sentences
Summary
After incubation with peptide AEDG, significant changes in the relative telomere length were found in 7 of 11 individuals (3 cases in the younger age group and 4 cases in the middle age group).
1 context sentence(design, population, supporting numbers)
Summary · context
We studied the effect of peptide AEDG on telomere length and mitotic index of PHA-stimulated blood lymphocytes from young (18-22 years, N=5) and middle-aged (49-54 years, N=6) men.
Report a problemFND-3176198701
02LabEx vivo tissueEfficacy outcome
In PHA-stimulated blood lymphocytes from young and middle-aged men, AEDG significantly increased telomere length in 5 of 11 individuals.
In plain wordsIn lab-grown blood cells from 11 donors, AEDG lengthened telomeres in 5 donors.
Peptide
Epitalon
Outcome
IncreaseRelative telomere length, increase
Study
humann = 11
PHA-stimulated blood lymphocytes
Outcome group
Aging markers · Aging and longevity
Studied dose
Dose not stated
Source sentences
Summary
Significant increase in telomere length after exposure to peptide AEDG was revealed in 5 cases, including two individuals of the younger age group (by 41 and 55%) and three individuals of the middle age group (by 156, 18, and 76%).
1 context sentence(design, population, supporting numbers)
Summary · context
We studied the effect of peptide AEDG on telomere length and mitotic index of PHA-stimulated blood lymphocytes from young (18-22 years, N=5) and middle-aged (49-54 years, N=6) men.
Report a problemFND-3176198702
03LabEx vivo tissueEfficacy outcome
In PHA-stimulated blood lymphocytes, AEDG significantly decreased telomere length in one young and one middle-aged individual.
In plain wordsIn lab-grown blood cells, AEDG shortened telomeres in cells from two of the 11 donors.
Peptide
Epitalon
Outcome
DecreaseRelative telomere length, decrease
Study
humann = 11
PHA-stimulated blood lymphocytes
Outcome group
Aging markers · Aging and longevity
Studied dose
Dose not stated
Source sentences
Summary
In one individual of the younger age group and in one of the middle-age group, a significant decrease in telomere length (by 37 and 15%, respectively) was found.
1 context sentence(design, population, supporting numbers)
Summary · context
We studied the effect of peptide AEDG on telomere length and mitotic index of PHA-stimulated blood lymphocytes from young (18-22 years, N=5) and middle-aged (49-54 years, N=6) men.
Report a problemFND-3176198703
04LabEx vivo tissueEfficacy outcome
In PHA-stimulated lymphocytes, AEDG tended to normalize telomere length: it rose where initial length was low and fell where it was high.
In plain wordsIn lab-grown blood cells, AEDG tended to move telomere lengths toward the group average.
Peptide
Epitalon
Outcome
MixedTelomere length normalization
Study
humann = 11
PHA-stimulated blood lymphocytes
Outcome group
Aging markers · Aging and longevity
Studied dose
Dose not stated
Source sentences
Summary
A tendency to normalization of telomere lengths was noted: this parameter increased in individuals with initially lower telomere length relative to the group mean value and decreased in individuals with initially longer telomeres compared to the mean length in the group.
1 context sentence(design, population, supporting numbers)
Summary · context
We studied the effect of peptide AEDG on telomere length and mitotic index of PHA-stimulated blood lymphocytes from young (18-22 years, N=5) and middle-aged (49-54 years, N=6) men.
Report a problemFND-3176198704
05LabEx vivo tissueEfficacy outcome
In PHA-stimulated lymphocytes from middle-aged men, AEDG decreased the mitotic index in one case.
In plain wordsIn lab-grown blood cells from middle-aged donors, AEDG lowered the rate of cell division in one case.
Peptide
Epitalon
Outcome
DecreaseMitotic index in middle-aged men
Study
humann = 6
PHA-stimulated blood lymphocytes
Outcome group
Aging markers · Aging and longevity
Studied dose
Dose not stated
Source sentences
Summary
while in the middle-aged group, a decrease in this parameter was found in one case.
1 context sentence(design, population, supporting numbers)
Summary · context
We studied the effect of peptide AEDG on telomere length and mitotic index of PHA-stimulated blood lymphocytes from young (18-22 years, N=5) and middle-aged (49-54 years, N=6) men.
Report a problemFND-3176198706
06LabEx vivo tissueEfficacy outcome
In PHA-stimulated lymphocytes from young men, AEDG caused no significant change in the mitotic index.
In plain wordsIn lab-grown blood cells from young donors, AEDG did not change the rate of cell division.
Peptide
Epitalon
Outcome
No significant changeMitotic index in younger men
Study
humann = 5
PHA-stimulated blood lymphocytes
Outcome group
Aging markers · Aging and longevity
Studied dose
Dose not stated
Source sentences
Summary
In the younger age group, no significant changes in the mitotic index were detected
1 context sentence(design, population, supporting numbers)
Summary · context
We studied the effect of peptide AEDG on telomere length and mitotic index of PHA-stimulated blood lymphocytes from young (18-22 years, N=5) and middle-aged (49-54 years, N=6) men.
Report a problemFND-3176198705

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
10 Oct 2026, 08:19 UTC
Study results updated
Version 1
9 Oct 2026, 02:47 UTC
First added · source update from Europe PMC

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Terms as the source lists them.

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Journal Article

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