Skip to content

Study · In vitro (cells) · 2019

3 results

The Use of Human Induced Pluripotent Stem Cells for Testing Neuroprotective Activity of Pharmacological Compounds.

Novosadova EV, Arsenyeva EL, Antonov SA, Vanyushina YN, Malova TV, Komissarov AA, Illarioshkin SN, Khaspekov LG, Andreeva LA, Myasoedov NF, Tarantul VZ, Grivennikov IA

Biochemistry. Biokhimiia1 Nov 2019Cited by 5 (Europe PMC)

PMID31760919 (opens in a new tab)DOI10.1134/s0006297919110075 (opens in a new tab)PepBankPUB-31760919
Publisher pagePubMedAsk about this study
Jump to 3 results

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

1 result from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Efficacy outcome

    In human iPSC-derived cultures enriched with dopaminergic neurons and exposed to hydrogen peroxide, Semax had a neuroprotective effect of about 40%.

    In plain wordsIn cells, Semax had a neuroprotective effect of about 40% against hydrogen peroxide; one other compound had a larger effect.

    Peptide
    Semax
    Outcome
    IncreaseNeuroprotective effect against hydrogen peroxide
    Study

    humann: not reported in source

    IPSC-derived differentiated cultures enriched with dopaminergic neurons, hydrogen peroxide
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Measurements

    Neuroprotective effect
    ≈ 40%
    Semax, dopaminergic neuron-enriched cultures

    Source sentences

    Summary
    the effect of melanocortin Semax was ~40%.
    1 context sentence
    Summary · context
    neuroprotective effect in the neuronal precursors and IPSC-derived neurons subjected to hydrogen peroxide.

Studies that did not test the peptide alone2

In this study, Semax was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Semax.

  1. 02LabNot a test of Semax aloneIn vitro (cells)Safety outcome

    In human iPSC models, none of the tested compounds (melanocortin peptides and endocannabinoids pooled) showed cytotoxicity or embryotoxicity.

    In plain wordsIn cells, none of the tested compounds, including melanocortin peptides and endocannabinoids as groups, was toxic to the cells.

    Peptide
    Semax
    Outcome
    No significant changeCytotoxicity and embryotoxicity of tested compounds
    Study

    humann: not reported in source

    Human iPSCs and IPSC-derived neuronal precursors and neurons
    Outcome group
    Adverse events · Nervous system and cognition

    Source sentences

    Summary
    None of the tested compounds displayed cyto- or embryotoxicity.
    1 context sentence
    Summary · context
    using two classes of compounds - melanocortin family peptides and endocannabinoids.

    In this study, Semax was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Semax.

  2. 03LabNot a test of Semax aloneIn vitro (cells)Efficacy outcome

    In human iPSC-derived neuronal cells exposed to hydrogen peroxide, melanocortin peptides and endocannabinoids, pooled as classes, both had a neuroprotective effect.

    In plain wordsIn cells, groups of melanocortin peptides and endocannabinoids both protected nerve cells from hydrogen peroxide damage.

    Peptide
    Semax
    Outcome
    IncreaseNeuroprotection against hydrogen peroxide
    Study

    humann: not reported in source

    Neuronal precursors and IPSC-derived neurons exposed to hydrogen peroxide
    Outcome group
    Neuroprotection · Nervous system and cognition

    Source sentences

    Summary
    Both melanocortin peptides and endocannabinoids exerted neuroprotective effect in the neuronal precursors and IPSC-derived neurons subjected to hydrogen peroxide.
    1 context sentence
    Summary · context
    using two classes of compounds - melanocortin family peptides and endocannabinoids.

    In this study, Semax was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Semax.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    10 Oct 2026, 10:21 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

PepBank is a research reference. Talk to a doctor before you use any peptide.