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Study · Randomized controlled trial · n = 10 · 2020

2 results

Oxytocin reduces the functional connectivity between brain regions involved in eating behavior in men with overweight and obesity.

Kerem L, Hadjikhani N, Holsen L, Lawson EA, Plessow F

International journal of obesity (2005)18 Nov 2019Cited by 30 (Europe PMC)

PMID31740723 (opens in a new tab)PMCIDPMC7192759 (opens in a new tab)DOI10.1038/s41366-019-0489-7 (opens in a new tab)PepBankPUB-31740723
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

2 results from studies that gave the peptide. 2 results from people.

  1. 01HumanRandomized controlled trialMechanism

    In men with overweight or obesity, intranasal oxytocin reduced functional connectivity between the ventral tegmental area and the insula, oral somatosensory cortex, amygdala, hippocampus, operculum and middle temporal gyrus when viewing high-calorie foods, compared with placebo.

    In plain wordsIn men with overweight or obesity, oxytocin weakened links between a brain reward area and food-related areas when viewing high-calorie foods, compared with placebo.

    Peptide
    Oxytocin
    Outcome
    DecreaseVTA functional connectivity with food motivation regions, high-calorie food images
    Study

    n = 10

    Comparator
    Placebo
    Outcome group
    Appetite and food intake · Nervous system and cognition
    Studied dose
    24 IU · intranasalAs given in this study (human).

    Source sentences

    Summary
    Following OXT administration, compared with placebo, participants exhibited significantly attenuated functional connectivity between the VTA and the insula, oral somatosensory cortex, amygdala, hippocampus, operculum, and middle temporal gyrus in response to viewing high-calorie foods (Z ≥ 3.1, clus…
    1 context sentence
    Summary · context
    This randomized, double-blind, and placebo-controlled crossover study of 24 IU IN OXT included ten men with overweight or obesity (mean ± SEM BMI: 28.9 ± 0.8 kg/m2).
  2. 02HumanRandomized controlled trialMechanism

    In men with overweight or obesity, oxytocin did not change functional connectivity between the ventral tegmental area and these brain areas for low-calorie food, nonfood or fixation images, compared with placebo.

    In plain wordsIn men with overweight or obesity, oxytocin did not change these brain links for low-calorie food, objects or fixation images, compared with placebo.

    Peptide
    Oxytocin
    Outcome
    No significant changeVTA functional connectivity, low-calorie food, nonfood and fixation images
    Study

    n = 10

    Comparator
    Placebo
    Outcome group
    Appetite and food intake · Nervous system and cognition
    Studied dose
    24 IU · intranasalAs given in this study (human).

    Source sentences

    Summary
    There was no difference in functional connectivity between VTA and these brain areas when comparing OXT and placebo for low-calorie food, nonfood, and fixation images.
    1 context sentence
    Summary · context
    This randomized, double-blind, and placebo-controlled crossover study of 24 IU IN OXT included ten men with overweight or obesity (mean ± SEM BMI: 28.9 ± 0.8 kg/m2).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 00:50 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:49 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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