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Study · Animal study (in vivo) · rat · 2020

4 results

Mitochondrial-Derived Peptide MOTS-c Attenuates Vascular Calcification and Secondary Myocardial Remodeling via Adenosine Monophosphate-Activated Protein Kinase Signaling Pathway.

Wei M, Gan L, Liu Z, Liu L, Chang JR, Yin DC, Cao HL, Su XL, Smith WW

Cardiorenal medicine6 Nov 2019Cited by 48 (Europe PMC)

PMID31694019 (opens in a new tab)DOI10.1159/000503224 (opens in a new tab)PepBankPUB-31694019
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: CC BY-NC-ND. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In rats with vitamin D3 and nicotine-induced vascular calcification, MOTS‑c treatment significantly attenuated vascular calcification.

    In plain wordsIn rats with vascular calcification, MOTS‑c treatment reduced the calcification.

    Peptide
    MOTS-c
    Outcome
    DecreaseVascular calcification
    Study

    ratn: not reported in source

    Vitamin D3 plus nicotine-induced vascular calcification
    Outcome group
    Tissue calcification · Cardiovascular
    Studied dose
    5 mg/kg once a day · 4 weeksAs given in this study (rat).

    Source sentences

    Summary
    Our results showed that MOTS-c treatment significantly attenuated VC.
    1 context sentence
    Summary · context
    Vitamin D3 plus nicotine-treated rats were injected with MOTS-c at a dose of 5 mg/kg once a day for 4 weeks.
  2. 02AnimalAnimal study (in vivo)Mechanism

    In rats with vitamin D3 and nicotine-induced vascular calcification, MOTS‑c increased the level of phosphorylated AMPK.

    In plain wordsIn rats, MOTS‑c treatment raised the level of the active form of the enzyme AMPK.

    Peptide
    MOTS-c
    Outcome
    IncreasePhosphorylated AMPK level
    Study

    ratn: not reported in source

    Vitamin D3 plus nicotine-induced vascular calcification
    Outcome group
    Receptor activity and mechanism · Cardiovascular
    Studied dose
    5 mg/kg once a day · 4 weeksAs given in this study (rat).

    Source sentences

    Summary
    Furthermore, we found that the level of phosphorylated AMPK was increased and the expression levels of the AT-1 and ET-B receptors were decreased after MOTS-c treatment.
    1 context sentence
    Summary · context
    Vitamin D3 plus nicotine-treated rats were injected with MOTS-c at a dose of 5 mg/kg once a day for 4 weeks.
  3. 03AnimalAnimal study (in vivo)Mechanism

    In rats with vitamin D3 and nicotine-induced vascular calcification, MOTS‑c decreased the expression of the angiotensin II type 1 receptor.

    In plain wordsIn rats, MOTS‑c treatment lowered the amount of the angiotensin II type 1 receptor.

    Peptide
    MOTS-c
    Outcome
    DecreaseAT-1 receptor expression
    Study

    ratn: not reported in source

    Vitamin D3 plus nicotine-induced vascular calcification
    Outcome group
    Receptor activity and mechanism · Cardiovascular
    Studied dose
    5 mg/kg once a day · 4 weeksAs given in this study (rat).

    Source sentences

    Summary
    Furthermore, we found that the level of phosphorylated AMPK was increased and the expression levels of the AT-1 and ET-B receptors were decreased after MOTS-c treatment.
    1 context sentence
    Summary · context
    Vitamin D3 plus nicotine-treated rats were injected with MOTS-c at a dose of 5 mg/kg once a day for 4 weeks.
  4. 04AnimalAnimal study (in vivo)Mechanism

    In rats with vitamin D3 and nicotine-induced vascular calcification, MOTS‑c decreased the expression of the endothelin B receptor.

    In plain wordsIn rats, MOTS‑c treatment lowered the amount of the endothelin B receptor.

    Peptide
    MOTS-c
    Outcome
    DecreaseET-B receptor expression
    Study

    ratn: not reported in source

    Vitamin D3 plus nicotine-induced vascular calcification
    Outcome group
    Receptor activity and mechanism · Cardiovascular
    Studied dose
    5 mg/kg once a day · 4 weeksAs given in this study (rat).

    Source sentences

    Summary
    Furthermore, we found that the level of phosphorylated AMPK was increased and the expression levels of the AT-1 and ET-B receptors were decreased after MOTS-c treatment.
    1 context sentence
    Summary · context
    Vitamin D3 plus nicotine-treated rats were injected with MOTS-c at a dose of 5 mg/kg once a day for 4 weeks.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    9 Oct 2026, 18:17 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:47 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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