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Study · In vitro (cells) · 2019

4 results

Splicing factor-modulated generation of mechano growth factor regulates physiological processes in osteoblasts under mechanical stimuli.

Yi Q, Liu H, Feng J, Wu Y, Sun W, Ou M, Tang L

Cell adhesion & migration1 Dec 2019Cited by 11 (Europe PMC)

PMID31680616 (opens in a new tab)PMCIDPMC6844564 (opens in a new tab)DOI10.1080/19336918.2019.1686103 (opens in a new tab)PepBankPUB-31680616
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Summary

Mechanical stimuli influence various physiological processes in osteoblasts. We previously showed that mechano-growth factor (MGF), a splicing variant of insulin-like growth factor 1, is highly expressed in osteoblasts in response to mechanical stimuli. This study aims to explore the systemic functions of MGF in osteoblasts, and the mechanisms by which mechanical stress regulates the alternative splicing of Igf1 to generate MGF. We found that MGF promoted the proliferation and migration of osteoblasts, while it inhibited their differentiation via Erk1/2 pathway. Furthermore, cyclic stretching upregulated the expression of ASF/SF2, which in turn regulated the expression of MGF. Our findings indicate that mechanical stimuli influence the physiological responses of osteoblasts by increasing the expression of MGF, which is regulated by splicing factors.
CC BYText from Europe PMC. Highlighted sentences are the source of results.

Results from this study4

3 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Mechanism

    In osteoblasts, MGF promoted cell proliferation.

    In plain wordsIn cells, MGF increased the growth of bone-forming cells (osteoblasts).

    Peptide
    MGF / PEG-MGF
    Outcome
    IncreaseOsteoblast proliferation
    Study

    n: not reported in source

    osteoblasts
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    We found that MGF promoted the proliferation and migration of osteoblasts, while it inhibited their differentiation via Erk1/2 pathway.
  2. 02LabIn vitro (cells)Mechanism

    In osteoblasts, MGF promoted cell migration.

    In plain wordsIn cells, MGF increased the movement of bone-forming cells (osteoblasts).

    Peptide
    MGF / PEG-MGF
    Outcome
    IncreaseOsteoblast migration
    Study

    n: not reported in source

    osteoblasts
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    We found that MGF promoted the proliferation and migration of osteoblasts, while it inhibited their differentiation via Erk1/2 pathway.
  3. 03LabIn vitro (cells)Mechanism

    In osteoblasts, MGF inhibited differentiation via the Erk1/2 pathway.

    In plain wordsIn cells, MGF reduced the maturation of bone-forming cells (osteoblasts).

    Peptide
    MGF / PEG-MGF
    Outcome
    DecreaseOsteoblast differentiation
    Study

    n: not reported in source

    osteoblasts
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    We found that MGF promoted the proliferation and migration of osteoblasts, while it inhibited their differentiation via Erk1/2 pathway.

Natural levels measured1

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

  1. 04LabEndogenous levelIn vitro (cells)Mechanism

    In osteoblasts, cyclic stretching upregulated ASF/SF2, which in turn regulated the expression of the body's own MGF.

    In plain wordsIn cells, stretching raised a splicing factor (ASF/SF2) that controlled the body's own MGF expression.

    Peptide
    MGF / PEG-MGF
    Outcome
    Direction not reportedRegulation of MGF expression by ASF/SF2 under cyclic stretching
    Study

    n: not reported in source

    osteoblasts
    Outcome group
    Bone and joint · Musculoskeletal

    Source sentences

    Summary
    Furthermore, cyclic stretching upregulated the expression of ASF/SF2, which in turn regulated the expression of MGF.

    This result measures the body's own MGF / PEG-MGF. Nobody was given the peptide. It is not evidence about taking it.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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