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Study · In vitro (cells) · 2020

3 results

Inhibition of triggering receptor expressed on myeloid cells-1 impairs thrombin generation.

Di Pillo E, Carrasco K, Brustolin B, Boufenzer A, Jolly L, Derive M, Lacolley P, Regnault V, Gibot S

Journal of thrombosis and haemostasis : JTH27 Nov 2019Cited by 10 (Europe PMC)

PMID31680426 (opens in a new tab)DOI10.1111/jth.14677 (opens in a new tab)PepBankPUB-31680426
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Mechanism

    In human blood and isolated cells, LR12 reduced tissue factor activity.

    In plain wordsIn lab tests, LR12 reduced tissue factor activity.

    Peptide
    Nangibotide
    Outcome
    DecreaseTissue factor activity
    Study

    humann: not reported in source

    Primary monocytes and neutrophils and whole blood
    Outcome group
    Receptor activity and mechanism · Cardiovascular
    Studied dose
    Dose not stated

    Source sentences

    Summary
    LR12 dampened TF activity through the decrease of PtdSer exposure, leading to a reduction of thrombin generation.
    2 context sentences
    Summary · context
    We measured thrombin generation (TG) by the use of calibrated automated thrombography with whole blood, and isolated primary human neutrophils and monocytes upon stimulation with lipopolysaccharide (LPS).
    Summary · context
    A dodecapeptide (LR12) was used as a specific inhibitor of TREM-1.
  2. 02LabIn vitro (cells)Mechanism

    In human blood and isolated cells, LR12 reduced phosphatidylserine exposure.

    In plain wordsIn lab tests, LR12 reduced phosphatidylserine exposure.

    Peptide
    Nangibotide
    Outcome
    DecreasePhosphatidylserine exposure
    Study

    humann: not reported in source

    Primary monocytes and neutrophils and whole blood
    Outcome group
    Receptor activity and mechanism · Cardiovascular
    Studied dose
    Dose not stated

    Source sentences

    Summary
    LR12 dampened TF activity through the decrease of PtdSer exposure, leading to a reduction of thrombin generation.
    2 context sentences
    Summary · context
    We measured thrombin generation (TG) by the use of calibrated automated thrombography with whole blood, and isolated primary human neutrophils and monocytes upon stimulation with lipopolysaccharide (LPS).
    Summary · context
    A dodecapeptide (LR12) was used as a specific inhibitor of TREM-1.
  3. 03LabIn vitro (cells)Mechanism

    In human blood and isolated cells, LR12 reduced thrombin generation.

    In plain wordsIn lab tests, LR12 reduced thrombin generation.

    Peptide
    Nangibotide
    Outcome
    DecreaseThrombin generation
    Study

    humann: not reported in source

    Primary monocytes and neutrophils and whole blood
    Outcome group
    Receptor activity and mechanism · Cardiovascular
    Studied dose
    Dose not stated

    Source sentences

    Summary
    LR12 dampened TF activity through the decrease of PtdSer exposure, leading to a reduction of thrombin generation.
    2 context sentences
    Summary · context
    We measured thrombin generation (TG) by the use of calibrated automated thrombography with whole blood, and isolated primary human neutrophils and monocytes upon stimulation with lipopolysaccharide (LPS).
    Summary · context
    A dodecapeptide (LR12) was used as a specific inhibitor of TREM-1.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    27 Oct 2026, 18:20 UTC

    Study results updated

  2. Version 1

    27 Oct 2026, 16:32 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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