In anesthetized rats, central AICAR pretreatment eliminated leptin-induced gastric sympathoexcitation.
In plain wordsIn rats, central AICAR eliminated leptin-induced sympathetic nerve activation to the stomach compared with leptin alone.
- Peptide
- AICAR (acadesine)
- Outcome
- DecreaseGastric sympathoexcitation
- Study
ratn: not reported in source
Anesthetized rats receiving central leptin- Comparator
- Leptin without AICAR
- Outcome group
- Receptor activity and mechanism · Nervous system and cognition
Source sentences
Central pretreatment with AICAR or compound C eliminated not only leptin-induced gastric sympathoexcitation but also leptin-induced splenic sympathoexcitation.
2 context sentences(design, population, supporting numbers)
This study investigated the effects of an intracerebroventricular injection of leptin on the activities of sympathetic nerves innervating the stomach and spleen in anesthetized rats.
In addition, to investigate the role of AMP-activated protein kinase (AMPK), the effects of 5-aminoimidazole-4-carboxamide 1-beta-D-ribofuranoside (AICAR), an AMPK activator, or compound C, an AMPK inhibitor, on leptin-induced sympathoexcitation, were assessed.
In this study, AICAR (acadesine) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking AICAR (acadesine).