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Study · Other design · 2020

5 results

Neuroprotective Peptide NAPVSIPQ Antagonizes Ethanol Inhibition of L1 Adhesion by Promoting the Dissociation of L1 and Ankyrin-G.

Dou X, Lee JY, Charness ME

Biological psychiatry5 Sept 2019Cited by 13 (Europe PMC)

PMID31640849 (opens in a new tab)PMCIDPMC7056560 (opens in a new tab)DOI10.1016/j.biopsych.2019.08.020 (opens in a new tab)PepBankPUB-31640849
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

5 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabOther designMechanism

    In laboratory assays, femtomolar NAP stimulated L1-Y1229 phosphorylation at the ankyrin binding motif.

    In plain wordsIn lab tests, NAP increased phosphorylation at the L1 ankyrin binding site.

    Peptide
    Davunetide
    Outcome
    IncreaseL1-Y1229 phosphorylation
    Study

    n: not reported in source

    Intact cells, rat brain homogenates and purified protein fragments
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Femtomolar concentrationsAs given in this study.

    Source sentences

    Summary
    Femtomolar concentrations of NAP stimulated the phosphorylation of tyrosine-1229 (L1-Y1229) at the ankyrin binding motif of the L1 cytoplasmic domain, leading to the dissociation of L1 from ankyrin-G and the spectrin-actin cytoskeleton.
    2 context sentences
    Summary · context
    L1-ankyrin-G association was studied using immunoprecipitation, Western blotting, and immunofluorescence in NIH/3T3 cells transfected with wild-type and mutated human L1 genes.
    Summary · context
    Phosphorylation of the ankyrin binding motif in the L1 cytoplasmic domain was studied after NAP treatment of intact cells, rat brain homogenates, and purified protein fragments.
  2. 02LabOther designMechanism

    In laboratory assays, NAP-stimulated phosphorylation led to L1 dissociation from ankyrin-G.

    In plain wordsIn lab tests, NAP promoted separation of L1 from ankyrin-G.

    Peptide
    Davunetide
    Outcome
    IncreaseL1 dissociation from ankyrin-G
    Study

    n: not reported in source

    Intact cells, rat brain homogenates and purified protein fragments
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Femtomolar concentrationsAs given in this study.

    Source sentences

    Summary
    Femtomolar concentrations of NAP stimulated the phosphorylation of tyrosine-1229 (L1-Y1229) at the ankyrin binding motif of the L1 cytoplasmic domain, leading to the dissociation of L1 from ankyrin-G and the spectrin-actin cytoskeleton.
    2 context sentences
    Summary · context
    L1-ankyrin-G association was studied using immunoprecipitation, Western blotting, and immunofluorescence in NIH/3T3 cells transfected with wild-type and mutated human L1 genes.
    Summary · context
    Phosphorylation of the ankyrin binding motif in the L1 cytoplasmic domain was studied after NAP treatment of intact cells, rat brain homogenates, and purified protein fragments.
  3. 03LabOther designMechanism

    In laboratory assays, NAP-stimulated phosphorylation led to L1 dissociation from the spectrin-actin cytoskeleton.

    In plain wordsIn lab tests, NAP promoted separation of L1 from the spectrin-actin cytoskeleton.

    Peptide
    Davunetide
    Outcome
    IncreaseL1 dissociation from spectrin-actin cytoskeleton
    Study

    n: not reported in source

    Intact cells, rat brain homogenates and purified protein fragments
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Femtomolar concentrationsAs given in this study.

    Source sentences

    Summary
    Femtomolar concentrations of NAP stimulated the phosphorylation of tyrosine-1229 (L1-Y1229) at the ankyrin binding motif of the L1 cytoplasmic domain, leading to the dissociation of L1 from ankyrin-G and the spectrin-actin cytoskeleton.
    2 context sentences
    Summary · context
    L1-ankyrin-G association was studied using immunoprecipitation, Western blotting, and immunofluorescence in NIH/3T3 cells transfected with wild-type and mutated human L1 genes.
    Summary · context
    Phosphorylation of the ankyrin binding motif in the L1 cytoplasmic domain was studied after NAP treatment of intact cells, rat brain homogenates, and purified protein fragments.
  4. 04LabOther designMechanism

    In laboratory assays, NAP increased L1 association with EphB2.

    In plain wordsIn lab tests, NAP increased the association between L1 and EphB2.

    Peptide
    Davunetide
    Outcome
    IncreaseL1–EphB2 association
    Study

    n: not reported in source

    Intact cells, rat brain homogenates and purified protein fragments
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Femtomolar concentrationsAs given in this study.

    Source sentences

    Summary
    NAP increased the association of L1 and EphB2 and directly activated EphB2 phosphorylation of L1-Y1229.
    2 context sentences
    Summary · context
    L1-ankyrin-G association was studied using immunoprecipitation, Western blotting, and immunofluorescence in NIH/3T3 cells transfected with wild-type and mutated human L1 genes.
    Summary · context
    Phosphorylation of the ankyrin binding motif in the L1 cytoplasmic domain was studied after NAP treatment of intact cells, rat brain homogenates, and purified protein fragments.
  5. 05LabOther designMechanism

    In laboratory assays, NAP directly activated EphB2 phosphorylation of L1-Y1229.

    In plain wordsIn lab tests, NAP directly activated EphB2 phosphorylation of L1-Y1229.

    Peptide
    Davunetide
    Outcome
    IncreaseEphB2 phosphorylation of L1-Y1229
    Study

    n: not reported in source

    Intact cells, rat brain homogenates and purified protein fragments
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Femtomolar concentrationsAs given in this study.

    Source sentences

    Summary
    NAP increased the association of L1 and EphB2 and directly activated EphB2 phosphorylation of L1-Y1229.
    2 context sentences
    Summary · context
    L1-ankyrin-G association was studied using immunoprecipitation, Western blotting, and immunofluorescence in NIH/3T3 cells transfected with wild-type and mutated human L1 genes.
    Summary · context
    Phosphorylation of the ankyrin binding motif in the L1 cytoplasmic domain was studied after NAP treatment of intact cells, rat brain homogenates, and purified protein fragments.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    27 Oct 2026, 18:20 UTC

    Study results updated

  2. Version 1

    27 Oct 2026, 16:32 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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