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Study · Animal study (in vivo) · rat · 2019

5 results

Selank, Peptide Analogue of Tuftsin, Protects Against Ethanol-Induced Memory Impairment by Regulating of BDNF Content in the Hippocampus and Prefrontal Cortex in Rats.

Kolik LG, Nadorova AV, Antipova TA, Kruglov SV, Kudrin VS, Durnev AD

Bulletin of experimental biology and medicine1 Sept 2019Cited by 4 (Europe PMC)

PMID31625062 (opens in a new tab)DOI10.1007/s10517-019-04588-9 (opens in a new tab)PepBankPUB-31625062
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

5 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In 9-month-old rats not exposed to ethanol, Selank produced a cognitive-stimulating effect in the object recognition test.

    In plain wordsIn 9-month-old rats, Selank improved performance in a memory test.

    Peptide
    Selank
    Outcome
    IncreaseObject recognition in rats not exposed to ethanol
    Study

    ratn: not reported in source

    Outbred 9-month-old rats not exposed to ethanol
    Outcome group
    Cognition and memory · Nervous system and cognition
    Studied dose
    0.3 mg/kg a day · intraperitoneal · 7 daysAs given in this study (rat).

    Source sentences

    Summary
    In the object recognition test, Selank (0.3 mg/kg a day, 7 days, intraperitoneally) produced a cognitive-stimulating effect in 9 months rats not exposed to ethanol (p<0.05)
    1 context sentence
    Summary · context
    The effects of a peptide anxiolytic Selank synthesized on the basis of the endogenous peptide tuftsin on memory impairment and content of brain-derived neurotrophic factor (BDNF) in brain structures were analyzed in outbred rats receiving 10% ethanol as the only source of fluid for 30 weeks.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In rats withdrawing from chronic ethanol, Selank prevented the formation of ethanol-induced memory disturbances in the object recognition test.

    In plain wordsIn rats withdrawing from alcohol, Selank prevented memory problems caused by alcohol.

    Peptide
    Selank
    Outcome
    DecreaseEthanol-induced memory disturbance
    Study

    ratn: not reported in source

    Outbred rats; chronic ethanol intake for 30 weeks
    Outcome group
    Cognition and memory · Nervous system and cognition
    Studied dose
    0.3 mg/kg a day · intraperitoneal · 7 daysAs given in this study (rat).

    Source sentences

    Summary
    In the object recognition test, Selank (0.3 mg/kg a day, 7 days, intraperitoneally) produced a cognitive-stimulating effect in 9 months rats not exposed to ethanol (p<0.05) and prevented the formation of ethanol-induced memory and attention disturbances (p<0.01) developing during alcohol withdrawal.
    1 context sentence
    Summary · context
    The effects of a peptide anxiolytic Selank synthesized on the basis of the endogenous peptide tuftsin on memory impairment and content of brain-derived neurotrophic factor (BDNF) in brain structures were analyzed in outbred rats receiving 10% ethanol as the only source of fluid for 30 weeks.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In rats withdrawing from chronic ethanol, Selank prevented the formation of ethanol-induced attention disturbances in the object recognition test.

    In plain wordsIn rats withdrawing from alcohol, Selank prevented attention problems caused by alcohol.

    Peptide
    Selank
    Outcome
    DecreaseEthanol-induced attention disturbance
    Study

    ratn: not reported in source

    Outbred rats; chronic ethanol intake for 30 weeks
    Outcome group
    Cognition and memory · Nervous system and cognition
    Studied dose
    0.3 mg/kg a day · intraperitoneal · 7 daysAs given in this study (rat).

    Source sentences

    Summary
    In the object recognition test, Selank (0.3 mg/kg a day, 7 days, intraperitoneally) produced a cognitive-stimulating effect in 9 months rats not exposed to ethanol (p<0.05) and prevented the formation of ethanol-induced memory and attention disturbances (p<0.01) developing during alcohol withdrawal.
    1 context sentence
    Summary · context
    The effects of a peptide anxiolytic Selank synthesized on the basis of the endogenous peptide tuftsin on memory impairment and content of brain-derived neurotrophic factor (BDNF) in brain structures were analyzed in outbred rats receiving 10% ethanol as the only source of fluid for 30 weeks.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In ex vivo experiments in ethanol-exposed rats, Selank prevented the ethanol-induced increase in BDNF content in the hippocampus.

    In plain wordsIn rats exposed to alcohol, Selank prevented the alcohol-driven rise of the growth factor BDNF in the hippocampus.

    Peptide
    Selank
    Outcome
    DecreaseEthanol-induced BDNF increase in hippocampus
    Study

    ratn: not reported in source

    Outbred rats; chronic ethanol intake for 30 weeks
    Outcome group
    Neurotransmitters and neurotrophic factors · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In ex vivo experiments, Selank prevented ethanol-induced increase in BDNF content in the hippocampus and frontal cortex (p<0.05).
    1 context sentence
    Summary · context
    The effects of a peptide anxiolytic Selank synthesized on the basis of the endogenous peptide tuftsin on memory impairment and content of brain-derived neurotrophic factor (BDNF) in brain structures were analyzed in outbred rats receiving 10% ethanol as the only source of fluid for 30 weeks.
  5. 05AnimalAnimal study (in vivo)Efficacy outcome

    In ex vivo experiments in ethanol-exposed rats, Selank prevented the ethanol-induced increase in BDNF content in the frontal cortex.

    In plain wordsIn rats exposed to alcohol, Selank prevented the alcohol-driven rise of the growth factor BDNF in the frontal cortex.

    Peptide
    Selank
    Outcome
    DecreaseEthanol-induced BDNF increase in frontal cortex
    Study

    ratn: not reported in source

    Outbred rats; chronic ethanol intake for 30 weeks
    Outcome group
    Neurotransmitters and neurotrophic factors · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In ex vivo experiments, Selank prevented ethanol-induced increase in BDNF content in the hippocampus and frontal cortex (p<0.05).
    1 context sentence
    Summary · context
    The effects of a peptide anxiolytic Selank synthesized on the basis of the endogenous peptide tuftsin on memory impairment and content of brain-derived neurotrophic factor (BDNF) in brain structures were analyzed in outbred rats receiving 10% ethanol as the only source of fluid for 30 weeks.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    9 Oct 2026, 19:08 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

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