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Study · In vitro (cells) · rat · 2019

4 results

Oxytocin induces intracellular Ca2+ release in cardiac fibroblasts from neonatal rats.

Ali II, Al-Salam S, Howarth FC, Shmygol A

Cell calcium4 Oct 2019Cited by 8 (Europe PMC)

PMID31614270 (opens in a new tab)DOI10.1016/j.ceca.2019.102099 (opens in a new tab)PepBankPUB-31614270
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Mechanism

    In neonatal rat ventricular myocytes, oxytocin increased the frequency of spontaneous Ca2+ transients.

    In plain wordsIn rat heart muscle cells grown in the lab, oxytocin made spontaneous calcium signals more frequent.

    Peptide
    Oxytocin
    Outcome
    IncreaseFrequency of spontaneous Ca2+ transients in myocytes
    Study

    ratn: not reported in source

    Neonatal rat ventricular myocytes and cardiac fibroblasts
    Outcome group
    Receptor activity and mechanism · Cardiovascular
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In myocytes, oxytocin increased the frequency of spontaneous Ca2+ transients
    1 context sentence
    Summary · context
    In the present study, we have investigated the direct effects of oxytocin on intracellular Ca2+ dynamics in ventricular myocytes and fibroblasts from new born rats.
  2. 02LabIn vitro (cells)Mechanism

    In neonatal rat ventricular myocytes, oxytocin decreased the amplitude of spontaneous Ca2+ transients.

    In plain wordsIn rat heart muscle cells grown in the lab, oxytocin made spontaneous calcium signals smaller.

    Peptide
    Oxytocin
    Outcome
    DecreaseAmplitude of spontaneous Ca2+ transients in myocytes
    Study

    ratn: not reported in source

    Neonatal rat ventricular myocytes and cardiac fibroblasts
    Outcome group
    Receptor activity and mechanism · Cardiovascular
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In myocytes, oxytocin increased the frequency of spontaneous Ca2+ transients and decreased their amplitude.
    1 context sentence
    Summary · context
    In the present study, we have investigated the direct effects of oxytocin on intracellular Ca2+ dynamics in ventricular myocytes and fibroblasts from new born rats.
  3. 03LabIn vitro (cells)Mechanism

    In neonatal rat cardiac fibroblasts, the data suggest that oxytocin receptors are present and functional in most cells.

    In plain wordsIn rat heart fibroblast cells in the lab, most cells appeared to have working oxytocin receptors.

    Peptide
    Oxytocin
    Outcome
    Not applicableFunctional oxytocin receptors in cardiac fibroblasts
    Study

    ratn: not reported in source

    Neonatal rat ventricular myocytes and cardiac fibroblasts
    Outcome group
    Receptor activity and mechanism · Cardiovascular
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Our data suggest that oxytocin receptors are also present and functional in the majority of cardiac fibroblasts.
    1 context sentence
    Summary · context
    In the present study, we have investigated the direct effects of oxytocin on intracellular Ca2+ dynamics in ventricular myocytes and fibroblasts from new born rats.
  4. 04LabIn vitro (cells)Mechanism

    In neonatal rat cardiac fibroblasts, oxytocin induced Ca2+ signals by triggering endoplasmic reticulum Ca2+ release through inositol trisphosphate activated receptors.

    In plain wordsIn rat heart fibroblast cells in the lab, oxytocin triggered calcium signals by releasing calcium stored inside the cell.

    Peptide
    Oxytocin
    Outcome
    IncreaseMechanism of oxytocin-induced Ca2+ signal in cardiac fibroblasts
    Study

    ratn: not reported in source

    Neonatal rat ventricular myocytes and cardiac fibroblasts
    Outcome group
    Receptor activity and mechanism · Cardiovascular
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Our findings suggest that oxytocin induces Ca2+ signals in cardiac fibroblasts by triggering endoplasmic reticulum Ca2+ release via inositol trisphosphate activated receptors.
    1 context sentence
    Summary · context
    In the present study, we have investigated the direct effects of oxytocin on intracellular Ca2+ dynamics in ventricular myocytes and fibroblasts from new born rats.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 01:30 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:48 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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